Open Access

Human papillomavirus‑16 infection and p16 expression in oral squamous cell carcinoma

  • Authors:
    • Norihiko Tokuzen
    • Koh-Ichi Nakashiro
    • Shin Tojo
    • Hiroyuki Goda
    • Nobuyuki Kuribayashi
    • Daisuke Uchida
  • View Affiliations

  • Published online on: May 14, 2021     https://doi.org/10.3892/ol.2021.12789
  • Article Number: 528
  • Copyright: © Tokuzen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Human papillomavirus (HPV) is a possible carcinogenetic factor in oral squamous cell carcinoma (OSCC). Previous studies have reported the prevalence of HPV in patients with OSCC. However, the association between HPV and OSCC remains controversial. The present study aimed to clarify the association between HPV infection, p16 protein expression and the clinicopathological characteristics of OSCC. The expression level of HPV‑16E6 mRNA and p16 protein, a known surrogate marker of HPV infection, was investigated in 100 OSCC cases using TaqMan reverse transcription‑quantitative PCR and immunohistochemistry staining, respectively. HPV‑16E6 mRNA expression level was only detected in one case (1%), and positive expression of p16 was found in 10 cases (10%), including an HPV‑positive case. Subsequently, the association between p16 expression level and clinicopathological characteristic factors were analyzed; however, no significant association was found. These results suggested that HPV‑16 infection was less likely to cause OSCC in Japan and p16 expression was not a suitable marker for HPV infection in OSCC.
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July-2021
Volume 22 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Tokuzen N, Nakashiro K, Tojo S, Goda H, Kuribayashi N and Uchida D: Human papillomavirus‑16 infection and p16 expression in oral squamous cell carcinoma. Oncol Lett 22: 528, 2021.
APA
Tokuzen, N., Nakashiro, K., Tojo, S., Goda, H., Kuribayashi, N., & Uchida, D. (2021). Human papillomavirus‑16 infection and p16 expression in oral squamous cell carcinoma. Oncology Letters, 22, 528. https://doi.org/10.3892/ol.2021.12789
MLA
Tokuzen, N., Nakashiro, K., Tojo, S., Goda, H., Kuribayashi, N., Uchida, D."Human papillomavirus‑16 infection and p16 expression in oral squamous cell carcinoma". Oncology Letters 22.1 (2021): 528.
Chicago
Tokuzen, N., Nakashiro, K., Tojo, S., Goda, H., Kuribayashi, N., Uchida, D."Human papillomavirus‑16 infection and p16 expression in oral squamous cell carcinoma". Oncology Letters 22, no. 1 (2021): 528. https://doi.org/10.3892/ol.2021.12789