Open Access

Formosanin C promotes the curative efficacy of ultrasound‑guided radiofrequency ablation in a mouse model of breast cancer

  • Authors:
    • Zhe Chen
    • Jing Li
    • Qianqian Cui
    • Fuyuan Li
    • Gaiying Zhang
  • View Affiliations

  • Published online on: May 24, 2021     https://doi.org/10.3892/ol.2021.12811
  • Article Number: 550
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Breast cancer is the leading cause of tumor‑associated death among women worldwide, and new therapeutic strategies are required to improve the post‑surgery prognosis and quality of life of patients. Radiofrequency ablation (RFA) is a less invasive approach compared with traditional surgical resection to treat malignancies, and the combination of RFA and chemotherapeutic agents, including formosanin C (FC), can synergistically improve the curative effects against breast carcinoma. However, the detailed mechanisms remain unclear. In the present study, nude mice were used to identify the influence of FC on the therapeutic efficacy of RFA for breast cancer. Flow cytometry was performed to demonstrate the proportional alteration of CD8+ and CD45+ T cells with different biomarkers, including CD107a, IFNγ and TNFα. It was demonstrated that FC enhanced the therapeutic efficacy of RFA in breast cancer, while RFA combined with FC improved the proportion of IFNγ+ and TNFα+ CD8+ T cells and CD107a+ CD8+ T cells in tumor‑infiltrating lymphocytes, thus increasing the immune responses caused by surgery and chemotherapy. The present study indicated that FC may promote the curative efficacy of ultrasound‑guided RFA against breast tumor by regulating adaptive immune responses.
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July-2021
Volume 22 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Chen Z, Li J, Cui Q, Li F and Zhang G: Formosanin C promotes the curative efficacy of ultrasound‑guided radiofrequency ablation in a mouse model of breast cancer. Oncol Lett 22: 550, 2021
APA
Chen, Z., Li, J., Cui, Q., Li, F., & Zhang, G. (2021). Formosanin C promotes the curative efficacy of ultrasound‑guided radiofrequency ablation in a mouse model of breast cancer. Oncology Letters, 22, 550. https://doi.org/10.3892/ol.2021.12811
MLA
Chen, Z., Li, J., Cui, Q., Li, F., Zhang, G."Formosanin C promotes the curative efficacy of ultrasound‑guided radiofrequency ablation in a mouse model of breast cancer". Oncology Letters 22.1 (2021): 550.
Chicago
Chen, Z., Li, J., Cui, Q., Li, F., Zhang, G."Formosanin C promotes the curative efficacy of ultrasound‑guided radiofrequency ablation in a mouse model of breast cancer". Oncology Letters 22, no. 1 (2021): 550. https://doi.org/10.3892/ol.2021.12811