Open Access

lncRNA SNHG7 promotes cell proliferation in glioma by acting as a competing endogenous RNA and sponging miR‑138‑5p to regulate EZH2 expression

  • Authors:
    • Yanyao Deng
    • Liuyang Cheng
    • Zhicheng Lv
    • Hongwei Zhu
    • Xiangrui Meng
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  • Published online on: May 29, 2021     https://doi.org/10.3892/ol.2021.12826
  • Article Number: 565
  • Copyright: © Deng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Glioma is the most common type of primary brain cancer in adults. Accumulating studies have reported that long non‑coding RNAs (lncRNAs) serve a significant role in the initiation and development of glioma. lncRNA small nucleolar RNA host gene 7 (SNHG7) has been previously demonstrated to serve a role in numerous glioma biological processes, including cell proliferation, invasion and migration. The present study aimed to investigate the role of SNHG7 in glioma through reverse transcription‑quantitative PCR, western blotting and cell function assays. The results revealed that SNHG7 expression was upregulated in glioma tissues and cell lines, while microRNA (miR)‑138‑5p expression was downregulated. Moreover, the knockdown of SNHG7 expression decreased the proliferation of glioma cells. Mechanistic studies demonstrated that SNHG7 downregulated miR‑138‑5p expression, which subsequently affected the expression levels of its target gene, enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2). In conclusion, the results of the present study suggested that SNHG7 may act as a competing endogenous RNA to sponge miR‑138‑5p and modulate EZH2 expression. Thus, SNHG7 may enhance glioma proliferation via modulating the miR‑138‑5p/EZH2 signaling axis.
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July-2021
Volume 22 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Deng Y, Cheng L, Lv Z, Zhu H and Meng X: lncRNA SNHG7 promotes cell proliferation in glioma by acting as a competing endogenous RNA and sponging miR‑138‑5p to regulate EZH2 expression. Oncol Lett 22: 565, 2021.
APA
Deng, Y., Cheng, L., Lv, Z., Zhu, H., & Meng, X. (2021). lncRNA SNHG7 promotes cell proliferation in glioma by acting as a competing endogenous RNA and sponging miR‑138‑5p to regulate EZH2 expression. Oncology Letters, 22, 565. https://doi.org/10.3892/ol.2021.12826
MLA
Deng, Y., Cheng, L., Lv, Z., Zhu, H., Meng, X."lncRNA SNHG7 promotes cell proliferation in glioma by acting as a competing endogenous RNA and sponging miR‑138‑5p to regulate EZH2 expression". Oncology Letters 22.1 (2021): 565.
Chicago
Deng, Y., Cheng, L., Lv, Z., Zhu, H., Meng, X."lncRNA SNHG7 promotes cell proliferation in glioma by acting as a competing endogenous RNA and sponging miR‑138‑5p to regulate EZH2 expression". Oncology Letters 22, no. 1 (2021): 565. https://doi.org/10.3892/ol.2021.12826