Open Access

CXCR4 is a prognostic marker that inhibits the invasion and migration of gastric cancer by regulating VEGF expression

  • Authors:
    • Gaoyang Chen
    • Zhen Zhou
    • Jun Jin
    • Yan Zhou
    • Yanqing Liu
    • Weimin Wang
  • View Affiliations

  • Published online on: June 4, 2021     https://doi.org/10.3892/ol.2021.12848
  • Article Number: 587
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Metastasis is the main cause of poor prognosis of patients with gastric cancer (GC). Thus, current research is focused on identifying biomarkers that can predict the prognosis of patients with GC. C‑X‑C motif chemokine receptor 4 (CXCR4) and vascular endothelial growth factor (VEGF) have been reported to play important roles in different types of malignancies; however, their role in the prognosis of GC remains unknown. The present study aimed to investigate the potential role of CXCR4 and VEGF in predicting the prognosis of patients with GC. Immunohistochemistry analysis was performed to analyze the expression levels of CXCR4 and VEGF in a GC tissue microarray containing GC tissues and adjacent normal tissues. The association between CXCR4 or VEGF expression levels and the clinicopathological characteristics or survival outcomes were assessed. Furthermore, Transwell and wound healing assays were performed to determine the cell invasive and migratory abilities in vitro. The results demonstrated that CXCR4 promoted AGS cell invasion and migration by regulating VEGF expression. In addition, CXCR4 and VEGF expression levels were significantly upregulated in GC tissues compared with adjacent normal tissues, which was associated with a poorer overall survival (OS). Cox regression analysis demonstrated that both upregulated CXCR4 and VEGF expression were independent negative biomarkers of OS. To the best of our knowledge, the present study was the first to discover that CXCR4 and VEGF exert synergistic roles as efficient prognostic indicators for patients with GC.
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August-2021
Volume 22 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Chen G, Zhou Z, Jin J, Zhou Y, Liu Y and Wang W: CXCR4 is a prognostic marker that inhibits the invasion and migration of gastric cancer by regulating VEGF expression. Oncol Lett 22: 587, 2021.
APA
Chen, G., Zhou, Z., Jin, J., Zhou, Y., Liu, Y., & Wang, W. (2021). CXCR4 is a prognostic marker that inhibits the invasion and migration of gastric cancer by regulating VEGF expression. Oncology Letters, 22, 587. https://doi.org/10.3892/ol.2021.12848
MLA
Chen, G., Zhou, Z., Jin, J., Zhou, Y., Liu, Y., Wang, W."CXCR4 is a prognostic marker that inhibits the invasion and migration of gastric cancer by regulating VEGF expression". Oncology Letters 22.2 (2021): 587.
Chicago
Chen, G., Zhou, Z., Jin, J., Zhou, Y., Liu, Y., Wang, W."CXCR4 is a prognostic marker that inhibits the invasion and migration of gastric cancer by regulating VEGF expression". Oncology Letters 22, no. 2 (2021): 587. https://doi.org/10.3892/ol.2021.12848