Open Access

Comprehensive serum and tissue microRNA profiling in dedifferentiated liposarcoma

  • Authors:
    • Isaku Kohama
    • Naofumi Asano
    • Juntaro Matsuzaki
    • Yusuke Yamamoto
    • Tomofumi Yamamoto
    • Ryou-U Takahashi
    • Eisuke Kobayashi
    • Satoko Takizawa
    • Hiromi Sakamoto
    • Ken Kato
    • Hiroyuki Fujimoto
    • Hirotaka Chikuda
    • Akira Kawai
    • Takahiro Ochiya
  • View Affiliations

  • Published online on: June 29, 2021     https://doi.org/10.3892/ol.2021.12884
  • Article Number: 623
  • Copyright: © Kohama et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Sarcoma is a rare cancer with several subtypes; therefore, our understanding of the pathogenesis of sarcoma is limited, and designing effective treatments is difficult. Circulating microRNAs (miRNAs), including exosomal miRNAs, have attracted attention as biomarkers in cancer. However, the roles of miRNAs and exosomes in sarcoma remain unclear. The present analysis of tissue and serum miRNA expression in osteosarcoma, Ewing's sarcoma and dedifferentiated liposarcoma (DDLPS) identified miR‑1246, ‑4532, ‑4454, ‑619‑5p and ‑6126 as biomarkers for DDLPS. These miRNAs were highly expressed in human DDLPS cell lines and exosomes, suggesting that they are secreted from DDLPS tissues. The present results suggested that specific miRNAs may be used as biomarkers for early diagnosis or treatment targets in DDLPS.
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August-2021
Volume 22 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Kohama I, Asano N, Matsuzaki J, Yamamoto Y, Yamamoto T, Takahashi R, Kobayashi E, Takizawa S, Sakamoto H, Kato K, Kato K, et al: Comprehensive serum and tissue microRNA profiling in dedifferentiated liposarcoma. Oncol Lett 22: 623, 2021.
APA
Kohama, I., Asano, N., Matsuzaki, J., Yamamoto, Y., Yamamoto, T., Takahashi, R. ... Ochiya, T. (2021). Comprehensive serum and tissue microRNA profiling in dedifferentiated liposarcoma. Oncology Letters, 22, 623. https://doi.org/10.3892/ol.2021.12884
MLA
Kohama, I., Asano, N., Matsuzaki, J., Yamamoto, Y., Yamamoto, T., Takahashi, R., Kobayashi, E., Takizawa, S., Sakamoto, H., Kato, K., Fujimoto, H., Chikuda, H., Kawai, A., Ochiya, T."Comprehensive serum and tissue microRNA profiling in dedifferentiated liposarcoma". Oncology Letters 22.2 (2021): 623.
Chicago
Kohama, I., Asano, N., Matsuzaki, J., Yamamoto, Y., Yamamoto, T., Takahashi, R., Kobayashi, E., Takizawa, S., Sakamoto, H., Kato, K., Fujimoto, H., Chikuda, H., Kawai, A., Ochiya, T."Comprehensive serum and tissue microRNA profiling in dedifferentiated liposarcoma". Oncology Letters 22, no. 2 (2021): 623. https://doi.org/10.3892/ol.2021.12884