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Temozolomide abrogates the aggressiveness of urothelial carcinoma cells by enhancing senescence and depleting the side population

  • Authors:
    • Na-Yon Kim
    • Sung-Hyun Hwang
    • Yeseul Yang
    • Yongbaek Kim
  • View Affiliations / Copyright

    Affiliations: Laboratory of Veterinary Clinical Pathology, College of Veterinary Medicine, Seoul National University, Seoul 08826, Republic of Korea
    Copyright: © Kim et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 845
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    Published online on: October 21, 2021
       https://doi.org/10.3892/ol.2021.13106
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Abstract

Patients with advanced urothelial carcinoma (UC) generally have poor prognoses due to therapeutic resistance. Furthermore, there are limited treatment options for advanced UC. Therefore, novel or effective chemotherapeutic agents are needed to improve patient survival. The present study was conducted to investigate the effect of temozolomide (TMZ) on UC cells so as to identify a potential method to overcome therapeutic resistance. TMZ is an alkylating agent with a target different from that of other anticancer drugs used to treat UC, such as cisplatin. TMZ enhanced the autophagic response and senescence, which was mediated via the p53 and p21 pathways. Inhibiting the autophagic response using chloroquine synergistically augmented the cytotoxic effect of TMZ on UC cells. TMZ significantly reduced the invasiveness of UC cells. Notably, the abundance of side population fraction was also significantly reduced following TMZ treatment. Considering that side population fraction is known to confer therapeutic resistance, it is noteworthy that the TMZ treatment markedly decreased side population fraction. Altogether, TMZ may have the potential to be applied as a part of an alternative treatment strategy to reduce the malignancy of UC cells.
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1 

Sjödahl G, Lauss M, Lövgren K, Chebil G, Gudjonsson S, Veerla S, Patschan O, Aine M, Fernö M, Ringnér M, et al: A molecular taxonomy for urothelial carcinoma. Clin Cancer Res. 18:3377–3386. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Antoni S, Ferlay J, Soerjomataram I, Znaor A, Jemal A and Bray F: Bladder cancer incidence and mortality: A global overview and recent trends. Eur Urol. 71:96–108. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Gui Y, Guo G, Huang Y, Hu X, Tang A, Gao S, Wu R, Chen C, Li X, Zhou L, et al: Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder. Nat Genet. 43:875–878. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Chen M, Zhuang C, Liu Y, Li J, Dai F, Xia M, Zhan Y, Lin J, Chen Z, He A, et al: Tetracycline-inducible shRNA targeting antisense long non-coding RNA HIF1A-AS2 represses the malignant phenotypes of bladder cancer. Cancer Lett. 376:155–164. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Koufopoulou M, Miranda PA, Kazmierska P, Deshpande S and Gaitonde P: Clinical evidence for the first line treatment of advanced urothelial carcinoma: Current paradigms and emerging treatment options. Cancer Treat Rev. 89:1020722020. View Article : Google Scholar : PubMed/NCBI

6 

Bellmunt J, de Wit R, Vaughn DJ, Fradet Y, Lee J-L, Fong L, Vogelzang NJ, Climent MA, Petrylak DP, Choueiri TK, et al KEYNOTE-045 Investigators, : Pembrolizumab as second line therapy for advanced urothelial carcinoma. N Engl J Med. 376:1015–1026. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Stupp R, Hegi ME, Mason WP, van den Bent MJ, Taphoorn MJ, Janzer RC, Ludwin SK, Allgeier A, Fisher B, Belanger K, et al European Organisation for Research and Treatment of Cancer Brain Tumour and Radiation Oncology Groups; National Cancer Institute of Canada Clinical Trials Group, : Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet Oncol. 10:459–466. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Woll PJ, Judson I, Lee SM, Rodenhuis S, Nielsen OS, Buesa JM, Lorigan PC, Leyvraz S, Hermans C, van Glabbeke M, et al: Temozolomide in adult patients with advanced soft tissue sarcoma: A phase II study of the EORTC Soft Tissue and Bone Sarcoma Group. Eur J Cancer. 35:410–412. 1999. View Article : Google Scholar : PubMed/NCBI

9 

Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJ, Belanger K, Brandes AA, Marosi C, Bogdahn U, et al European Organisation for Research and Treatment of Cancer Brain Tumor and Radiotherapy Groups; National Cancer Institute of Canada Clinical Trials Group, : Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med. 352:987–996. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Wang HW, Xu ZK, Song Y and Liu YG: Correlations of MGMT genetic polymorphisms with temozolomide resistance and prognosis of patients with malignant gliomas: A population-based study in China. Cancer Gene Ther. 24:215–220. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Roos WP, Batista LF, Naumann SC, Wick W, Weller M, Menck CF and Kaina B: Apoptosis in malignant glioma cells triggered by the temozolomide-induced DNA lesion O6-methylguanine. Oncogene. 26:186–197. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Mhaidat NM, Zhang XD, Allen J, Avery-Kiejda KA, Scott RJ and Hersey P: Temozolomide induces senescence but not apoptosis in human melanoma cells. Br J Cancer. 97:1225–1233. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Sui X, Chen R, Wang Z, Huang Z, Kong N, Zhang M, Han W, Lou F, Yang J, Zhang Q, et al: Autophagy and chemotherapy resistance: A promising therapeutic target for cancer treatment. Cell Death Dis. 4:e8382013. View Article : Google Scholar : PubMed/NCBI

14 

Acosta JC and Gil J: Senescence: A new weapon for cancer therapy. Trends Cell Biol. 22:211–219. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Schmitt CA, Fridman JS, Yang M, Lee S, Baranov E, Hoffman RM and Lowe SW: A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy. Cell. 109:335–346. 2002. View Article : Google Scholar : PubMed/NCBI

16 

Ventura A, Kirsch DG, McLaughlin ME, Tuveson DA, Grimm J, Lintault L, Newman J, Reczek EE, Weissleder R and Jacks T: Restoration of p53 function leads to tumour regression in vivo. Nature. 445:661–665. 2007. View Article : Google Scholar : PubMed/NCBI

17 

Yang X, Qu K, Tao J, Yin G, Han S, Liu Q and Sun H: Inhibition of CIP2A attenuates tumor progression by inducing cell cycle arrest and promoting cellular senescence in hepatocellular carcinoma. Biochem Biophys Res Commun. 495:1807–1814. 2018. View Article : Google Scholar : PubMed/NCBI

18 

Codogno P and Meijer AJ: Autophagy and signaling: Their role in cell survival and cell death. Cell Death Differ. 12 (Suppl 2):1509–1518. 2005. View Article : Google Scholar : PubMed/NCBI

19 

Rosenfeldt MT and Ryan KM: The role of autophagy in tumour development and cancer therapy. Expert Rev Mol Med. 11:e362009. View Article : Google Scholar : PubMed/NCBI

20 

Manic G, Obrist F, Kroemer G, Vitale I and Galluzzi L: Chloroquine and hydroxychloroquine for cancer therapy. Mol Cell Oncol. 1:e299112014. View Article : Google Scholar : PubMed/NCBI

21 

Wang M, Liao C, Hu Y, Qinwen Pan and Jiang J: Sensitization of breast cancer cells to paclitaxel by dichloroacetate through inhibiting autophagy. Biochem Biophys Res Commun. 489:103–108. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Mahoney JR and Eaton JW: Chloroquine resistant malaria: Association with enhanced plasmodial protease activity. Biochem Biophys Res Commun. 100:1266–1271. 1981. View Article : Google Scholar : PubMed/NCBI

23 

Kimura T, Takabatake Y, Takahashi A and Isaka Y: Chloroquine in cancer therapy: A double-edged sword of autophagy. Cancer Res. 73:3–7. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Verschooten L, Barrette K, Van Kelst S, Rubio Romero N, Proby C, De Vos R, Agostinis P and Garmyn M: Autophagy inhibitor chloroquine enhanced the cell death inducing effect of the flavonoid luteolin in metastatic squamous cell carcinoma cells. PLoS One. 7:e482642012. View Article : Google Scholar : PubMed/NCBI

25 

Amaravadi RK, Yu D, Lum JJ, Thomas Tikhonenko A and Thompson CB: Inhibition of autophagy with chloroquine enhances therapeutic tumor regression in a mouse model of B cell lymphoma. Cancer Res. 66:14482006.

26 

Liu T, Zhang J, Li K, Deng L and Wang H: Combination of an autophagy inducer and an autophagy inhibitor: A smarter strategy emerging in cancer therapy. Front Pharmacol. 11:4082020. View Article : Google Scholar : PubMed/NCBI

27 

Kim NY, Kim MC and Kim Y: Hypomethylation reduced the aggressive potential of human malignant mesothelioma cells. Cancer Gene Ther. 23:425–432. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Kim HA, Kim MC, Kim NY and Kim Y: Inhibition of hedgehog signaling reduces the side population in human malignant mesothelioma cell lines. Cancer Gene Ther. 22:387–395. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Sun Z, Niu S, Xu F, Zhao W, Ma R and Chen M: CircAMOTL1 promotes tumorigenesis through miR 526b/SIK2 axis in cervical cancer. Front Cell Dev Biol. 8:5681902020. View Article : Google Scholar : PubMed/NCBI

30 

Leikam C, Hufnagel A, Schartl M and Meierjohann S: Oncogene activation in melanocytes links reactive oxygen to multinucleated phenotype and senescence. Oncogene. 27:7070–7082. 2008. View Article : Google Scholar : PubMed/NCBI

31 

Ning ZF, Huang YJ, Lin TX, Zhou YX, Jiang C, Xu KW, Huang H, Yin XB and Huang J: Subpopulations of stem-like cells in side population cells from the human bladder transitional cell cancer cell line T24. J Int Med Res. 37:621–630. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Chen M, Wei X, Shi X, Lu L, Zhang G, Huang Y and Hou J: LncRNA HIF1A-AS2 accelerates malignant phenotypes of renal carcinoma by modulating miR-30a-5p/SOX4 axis as a ceRNA. Cancer Biol Med. 18:587–603. 2021. View Article : Google Scholar : PubMed/NCBI

33 

Kai K, D'Costa S, Yoon BI, Brody AR, Sills RC and Kim Y: Characterization of side population cells in human malignant mesothelioma cell lines. Lung Cancer. 70:146–151. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Ewald JA, Desotelle JA, Wilding G and Jarrard DF: Therapy-induced senescence in cancer. J Natl Cancer Inst. 102:1536–1546. 2010. View Article : Google Scholar : PubMed/NCBI

35 

Yi G, He Z, Zhou X, Xian L, Yuan T, Jia X, Hong J, He L and Liu J: Low concentration of metformin induces a p53-dependent senescence in hepatoma cells via activation of the AMPK pathway. Int J Oncol. 43:1503–1510. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Olivier M, Petitjean A, Marcel V, Pétré A, Mounawar M, Plymoth A, de Fromentel CC and Hainaut P: Recent advances in p53 research: An interdisciplinary perspective. Cancer Gene Ther. 16:1–12. 2009. View Article : Google Scholar : PubMed/NCBI

37 

Chang BD, Xuan Y, Broude EV, Zhu H, Schott B, Fang J and Roninson IB: Role of p53 and p21waf1/cip1 in senescence-like terminal proliferation arrest induced in human tumor cells by chemotherapeutic drugs. Oncogene. 18:4808–4818. 1999. View Article : Google Scholar : PubMed/NCBI

38 

Yang D, Song J, Wu L, Ma Y, Song C, Dovat S, Nishizaki T and Liu J: Induction of senescence by adenosine suppressing the growth of lung cancer cells. Biochem Biophys Res Commun. 440:62–67. 2013. View Article : Google Scholar : PubMed/NCBI

39 

Li P, Zhao M, Parris AB, Feng X and Yang X: p53 is required for metformin-induced growth inhibition, senescence and apoptosis in breast cancer cells. Biochem Biophys Res Commun. 464:1267–1274. 2015. View Article : Google Scholar : PubMed/NCBI

40 

Gewirtz DA, Holt SE and Elmore LW: Accelerated senescence: An emerging role in tumor cell response to chemotherapy and radiation. Biochem Pharmacol. 76:947–957. 2008. View Article : Google Scholar : PubMed/NCBI

41 

Moserle L, Ghisi M, Amadori A and Indraccolo S: Side population and cancer stem cells: Therapeutic implications. Cancer Lett. 288:1–9. 2010. View Article : Google Scholar : PubMed/NCBI

42 

Tanida I, Ueno T and Kominami E: LC3 and autophagy. Methods Mol Biol. 445:77–88. 2008. View Article : Google Scholar : PubMed/NCBI

43 

Rotondo R, Oliva MA, Staffieri S, Castaldo S, Giangaspero F and Arcella A: Implication of lactucopicrin in autophagy, cell cycle arrest and oxidative stress to inhibit U87Mg glioblastoma cell growth. Molecules. 25:58432020. View Article : Google Scholar : PubMed/NCBI

44 

Moghadam AR, da Silva Rosa SC, Samiei E, Alizadeh J, Field J, Kawalec P, Thliveris J, Akbari M, Ghavami S and Gordon JW: Autophagy modulates temozolomide-induced cell death in alveolar Rhabdomyosarcoma cells. Cell Death Discov. 4:522018.Erratum in: Cell Death Discov 5: 116, 2019. View Article : Google Scholar : PubMed/NCBI

45 

Ganguli A, Choudhury D, Datta S, Bhattacharya S and Chakrabarti G: Inhibition of autophagy by chloroquine potentiates synergistically anti-cancer property of artemisinin by promoting ROS dependent apoptosis. Biochimie. 107((Pt B)): 338–349. 2014. View Article : Google Scholar : PubMed/NCBI

46 

Liang X, Tang J, Liang Y, Jin R and Cai X: Suppression of autophagy by chloroquine sensitizes 5-fluorouracil-mediated cell death in gallbladder carcinoma cells. Cell Biosci. 4:102014. View Article : Google Scholar : PubMed/NCBI

47 

Yoon YH, Cho KS, Hwang JJ, Lee SJ, Choi JA and Koh JY: Induction of lysosomal dilatation, arrested autophagy, and cell death by chloroquine in cultured ARPE-19 cells. Invest Ophthalmol Vis Sci. 51:6030–6037. 2010. View Article : Google Scholar : PubMed/NCBI

48 

Rao R, Balusu R, Fiskus W, Mudunuru U, Venkannagari S, Chauhan L, Smith JE, Hembruff SL, Ha K, Atadja P, et al: Combination of pan-histone deacetylase inhibitor and autophagy inhibitor exerts superior efficacy against triple-negative human breast cancer cells. Mol Cancer Ther. 11:973–983. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Kim N, Hwang S, Yang Y and Kim Y: Temozolomide abrogates the aggressiveness of urothelial carcinoma cells by enhancing senescence and depleting the side population. Oncol Lett 22: 845, 2021.
APA
Kim, N., Hwang, S., Yang, Y., & Kim, Y. (2021). Temozolomide abrogates the aggressiveness of urothelial carcinoma cells by enhancing senescence and depleting the side population. Oncology Letters, 22, 845. https://doi.org/10.3892/ol.2021.13106
MLA
Kim, N., Hwang, S., Yang, Y., Kim, Y."Temozolomide abrogates the aggressiveness of urothelial carcinoma cells by enhancing senescence and depleting the side population". Oncology Letters 22.6 (2021): 845.
Chicago
Kim, N., Hwang, S., Yang, Y., Kim, Y."Temozolomide abrogates the aggressiveness of urothelial carcinoma cells by enhancing senescence and depleting the side population". Oncology Letters 22, no. 6 (2021): 845. https://doi.org/10.3892/ol.2021.13106
Copy and paste a formatted citation
x
Spandidos Publications style
Kim N, Hwang S, Yang Y and Kim Y: Temozolomide abrogates the aggressiveness of urothelial carcinoma cells by enhancing senescence and depleting the side population. Oncol Lett 22: 845, 2021.
APA
Kim, N., Hwang, S., Yang, Y., & Kim, Y. (2021). Temozolomide abrogates the aggressiveness of urothelial carcinoma cells by enhancing senescence and depleting the side population. Oncology Letters, 22, 845. https://doi.org/10.3892/ol.2021.13106
MLA
Kim, N., Hwang, S., Yang, Y., Kim, Y."Temozolomide abrogates the aggressiveness of urothelial carcinoma cells by enhancing senescence and depleting the side population". Oncology Letters 22.6 (2021): 845.
Chicago
Kim, N., Hwang, S., Yang, Y., Kim, Y."Temozolomide abrogates the aggressiveness of urothelial carcinoma cells by enhancing senescence and depleting the side population". Oncology Letters 22, no. 6 (2021): 845. https://doi.org/10.3892/ol.2021.13106
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