Open Access

Function of BCLAF1 in human disease (Review)

  • Authors:
    • Zongdong Yu
    • Jie Zhu
    • Haibiao Wang
    • Hong Li
    • Xiaofeng Jin
  • View Affiliations

  • Published online on: December 22, 2021     https://doi.org/10.3892/ol.2021.13176
  • Article Number: 58
  • Copyright: © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Originally identified as a regulator of apoptosis and transcription, B‑cell lymphoma‑2‑associated transcription factor 1 (BCLAF1) has since been shown to be associated with a multitude of biological processes, such as DNA damage response, splicing and processing of pre‑mRNA, T‑cell activation, lung development, muscle cell proliferation and differentiation, autophagy, ischemia‑reperfusion injury, and viral infection. In recent years, an increasing amount of evidence has shown that BCLAF1 acts as either a tumor promoter or tumor suppressor in tumorigenesis depending on the cellular context and the type of cancer. Even in the same tumor type, BCLAF1 may have opposite effects. In the present review, the subcellular localization, structural features, mutations within BCLAF1 will be described, then the regulation of BCLAF1 and its downstream targets will be analyzed. Furthermore, the different roles and possible mechanisms of BCLAF1 in tumorigenesis will also be highlighted and discussed. Finally, BCLAF1 may be considered as a potential target for cancer therapy in the future.
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February-2022
Volume 23 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Yu Z, Zhu J, Wang H, Li H and Jin X: Function of BCLAF1 in human disease (Review). Oncol Lett 23: 58, 2022.
APA
Yu, Z., Zhu, J., Wang, H., Li, H., & Jin, X. (2022). Function of BCLAF1 in human disease (Review). Oncology Letters, 23, 58. https://doi.org/10.3892/ol.2021.13176
MLA
Yu, Z., Zhu, J., Wang, H., Li, H., Jin, X."Function of BCLAF1 in human disease (Review)". Oncology Letters 23.2 (2022): 58.
Chicago
Yu, Z., Zhu, J., Wang, H., Li, H., Jin, X."Function of BCLAF1 in human disease (Review)". Oncology Letters 23, no. 2 (2022): 58. https://doi.org/10.3892/ol.2021.13176