1
|
Schatten H: Brief overview of prostate
cancer statistics, grading, diagnosis and treatment strategies. Adv
Exp Med Biol. 1095:1–14. 2018. View Article : Google Scholar : PubMed/NCBI
|
2
|
Logothetis C, Morris MJ, Den R and Coleman
RE: Current perspectives on bone metastases in castrate-resistant
prostate cancer. Cancer Metastasis Rev. 37:189–196. 2018.
View Article : Google Scholar : PubMed/NCBI
|
3
|
Suarez-Carmona M, Lesage J, Cataldo D and
Gilles C: EMT and inflammation: Inseparable actors of cancer
progression. Mol Oncol. 11:805–823. 2017. View Article : Google Scholar : PubMed/NCBI
|
4
|
Du B and Shim JS: Targeting
epithelial-mesenchymal transition (EMT) to overcome drug resistance
in cancer. Molecules. 21:9652016. View Article : Google Scholar : PubMed/NCBI
|
5
|
Saitoh M: Involvement of partial EMT in
cancer progression. J Biochem. 164:257–264. 2018. View Article : Google Scholar : PubMed/NCBI
|
6
|
Huang T, Chen Z and Fang L: Curcumin
inhibits LPS-induced EMT through downregulation of NF-kappaB-snail
signaling in breast cancer cells. Oncol Rep. 29:117–124. 2013.
View Article : Google Scholar : PubMed/NCBI
|
7
|
Tian QX, Zhang ZH, Ye QL, Xu S, Hong Q,
Xing WY, Chen L, Yu DX, Xu DX and Xie DD: Melatonin inhibits
migration and invasion in LPS-stimulated and -unstimulated prostate
cancer cells through blocking multiple EMT-relative pathways. J
Inflamm Res. 14:2253–2265. 2021. View Article : Google Scholar : PubMed/NCBI
|
8
|
Wu Z, Chen CY, Kao CL, Jiang Y and Liu CM:
Docosahexaenoic acid inhibits lipopolysaccharide-induced metastatic
activities by decreasing inflammation on prostate cancer cell.
Pharmazie. 74:675–679. 2019.PubMed/NCBI
|
9
|
Li X, He S and Ma B: Autophagy and
autophagy-related proteins in cancer. Mol Cancer. 19:122020.
View Article : Google Scholar : PubMed/NCBI
|
10
|
Levy JMM, Towers CG and Thorburn A:
Targeting autophagy in cancer. Nat Rev Cancer. 17:528–542. 2017.
View Article : Google Scholar : PubMed/NCBI
|
11
|
Kim TW, Lee SY, Kim M, Cheon C and Ko SG:
Kaempferol induces autophagic cell death via IRE1-JNK-CHOP pathway
and inhibition of G9a in gastric cancer cells. Cell Death Dis.
9:8752018. View Article : Google Scholar : PubMed/NCBI
|
12
|
Zhang G, He J, Ye X, Zhu J, Hu X, Shen M,
Ma Y, Mao Z, Song H and Chen F: β-Thujaplicin induces autophagic
cell death, apoptosis, and cell cycle arrest through ROS-mediated
Akt and p38/ERK MAPK signaling in human hepatocellular carcinoma.
Cell Death Dis. 10:2552019. View Article : Google Scholar : PubMed/NCBI
|
13
|
Ramirez JA, Romagnoli GG and Kaneno R:
Inhibiting autophagy to prevent drug resistance and improve
anti-tumor therapy. Life Sci. 265:1187452021. View Article : Google Scholar : PubMed/NCBI
|
14
|
Mou Y, Wang J, Wu J, He D, Zhang C, Duan C
and Li B: Ferroptosis, a new form of cell death: opportunities and
challenges in cancer. J Hematol Oncol. 12:342019. View Article : Google Scholar : PubMed/NCBI
|
15
|
Lou JS, Zhao LP, Huang ZH, Chen XY, Xu JT,
Tai WC, Tsim KWK, Chen YT and Xie T: Ginkgetin derived from Ginkgo
biloba leaves enhances the therapeutic effect of cisplatin via
ferroptosis-mediated disruption of the Nrf2/HO-1 axis in EGFR
wild-type non-small-cell lung cancer. Phytomedicine. 80:1533702021.
View Article : Google Scholar : PubMed/NCBI
|
16
|
Zhang Y, Tan H, Daniels JD, Zandkarimi F,
Liu H, Brown LM, Uchida K, O'Connor OA and Stockwell BR: Imidazole
ketone erastin induces ferroptosis and slows tumor growth in a
mouse lymphoma model. Cell Chem Biol. 26:623–633. 2019. View Article : Google Scholar : PubMed/NCBI
|
17
|
Gundala SR, Mukkavilli R, Yang C, Yadav P,
Tandon V, Vangala S, Prakash S and Aneja R: Enterohepatic
recirculation of bioactive ginger phytochemicals is associated with
enhanced tumor growth-inhibitory activity of ginger extract.
Carcinogenesis. 35:1320–1329. 2014. View Article : Google Scholar : PubMed/NCBI
|
18
|
Hong MK, Hu LL, Zhang YX, Xu YL, Liu XY,
He PK and Jia YH: 6-Gingerol ameliorates sepsis-induced liver
injury through the Nrf2 pathway. Int Immunopharmacol.
80:1061962020. View Article : Google Scholar : PubMed/NCBI
|
19
|
Xu S, Zhang H, Liu T, Wang Z, Yang W, Hou
T, Wang X, He D and Zheng P: 6-Gingerol suppresses tumor cell
metastasis by increasing YAP(ser127) phosphorylation in renal cell
carcinoma. J Biochem Mol Toxicol. 35:e226092021. View Article : Google Scholar : PubMed/NCBI
|
20
|
Chen CY, Kao CL and Liu CM: The cancer
prevention, anti-inflammatory and anti-oxidation of bioactive
phytochemicals targeting the TLR4 signaling pathway. Int J Mol Sci.
19:27292018. View Article : Google Scholar : PubMed/NCBI
|
21
|
Liu CM, Kao CL, Tseng YT, Lo YC and Chen
CY: Ginger phytochemicals inhibit cell growth and modulate drug
resistance factors in docetaxel resistant prostate cancer cell.
Molecules. 22:14772017. View Article : Google Scholar : PubMed/NCBI
|
22
|
Brahmbhatt M, Gundala SR, Asif G, Shamsi
SA and Aneja R: Ginger phytochemicals exhibit synergy to inhibit
prostate cancer cell proliferation. Nutr Cancer. 65:263–272. 2013.
View Article : Google Scholar : PubMed/NCBI
|
23
|
Shukla Y, Prasad S, Tripathi C, Singh M,
George J and Kalra N: In vitro and in vivo modulation of
testosterone mediated alterations in apoptosis related proteins by
[6]-gingerol. Mol Nutr Food Res. 51:1492–1502. 2007. View Article : Google Scholar : PubMed/NCBI
|
24
|
Martin SK, Kamelgarn M and Kyprianou N:
Cytoskeleton targeting value in prostate cancer treatment. Am J
Clin Exp Urol. 2:15–26. 2014.PubMed/NCBI
|
25
|
Dai SN, Hou AJ, Zhao SM, Chen XM, Huang
HT, Chen BH and Kong HL: Ginsenoside Rb1 ameliorates autophagy of
hypoxia cardiomyocytes from neonatal rats via AMP-activated protein
kinase pathway. Chin J Integr Med. 25:521–528. 2019. View Article : Google Scholar : PubMed/NCBI
|
26
|
Ouyang DY, Xu LH, He XH, Zhang YT, Zeng
LH, Cai JY and Ren S: Autophagy is differentially induced in
prostate cancer LNCaP, DU145 and PC-3 cells via distinct splicing
profiles of ATG5. Autophagy. 9:20–32. 2013. View Article : Google Scholar : PubMed/NCBI
|
27
|
Li J, Cao F, Yin HL, Huang ZJ, Lin ZT, Mao
N, Sun B and Wang G: Ferroptosis: Past, present and future. Cell
Death Dis. 11:882020. View Article : Google Scholar : PubMed/NCBI
|
28
|
Yan HF, Zou T, Tuo QZ, Xu S, Li H, Belaidi
AA and Lei P: Ferroptosis: Mechanisms and links with diseases.
Signal Transduct Target Ther. 6:492021. View Article : Google Scholar : PubMed/NCBI
|
29
|
Yun DK, Lee J and Keum YS: Finasteride
increases the expression of hemoxygenase-1 (HO-1) and NF-E2-related
factor-2 (Nrf2) proteins in PC-3 cells: Implication of
finasteride-mediated high-grade prostate tumor occurrence. Biomol
Ther (Seoul). 21:49–53. 2013. View Article : Google Scholar : PubMed/NCBI
|
30
|
Sp N, Kang DY, Lee JM, Bae SW and Jang KJ:
Potential antitumor effects of 6-gingerol in p53-dependent
mitochondrial apoptosis and inhibition of tumor sphere formation in
breast cancer cells. Int J Mol Sci. 22:46602021. View Article : Google Scholar : PubMed/NCBI
|
31
|
Radhakrishnan EK, Bava SV, Narayanan SS,
Nath LR, Thulasidasan AK, Soniya EV and Anto RJ: [6]-Gingerol
induces caspase-dependent apoptosis and prevents PMA-induced
proliferation in colon cancer cells by inhibiting MAPK/AP-1
signaling. PLoS One. 9:e1044012014. View Article : Google Scholar : PubMed/NCBI
|
32
|
Kapoor V, Aggarwal S and Das SN:
6-gingerol mediates its anti tumor activities in human oral and
cervical cancer cell lines through apoptosis and cell cycle arrest.
Phytother Res. 30:588–595. 2016. View Article : Google Scholar : PubMed/NCBI
|
33
|
Babaei G, Aziz SG and Jaghi NZZ: EMT,
cancer stem cells and autophagy; The three main axes of metastasis.
Biomed Pharmacother. 133:1109092021. View Article : Google Scholar : PubMed/NCBI
|
34
|
Perez TD and Nelson WJ: Cadherin adhesion:
Mechanisms and molecular interactions. Handb Exp Pharmacol. 3–21.
2004. View Article : Google Scholar : PubMed/NCBI
|
35
|
Mendonsa AM, Na TY and Gumbiner BM:
E-cadherin in contact inhibition and cancer. Oncogene.
37:4769–4780. 2018. View Article : Google Scholar : PubMed/NCBI
|
36
|
Yu W, Yang L, Li T and Zhang Y: Cadherin
signaling in cancer: Its functions and role as a therapeutic
target. Front Oncol. 9:9892019. View Article : Google Scholar : PubMed/NCBI
|
37
|
Leggett SE, Hruska AM, Guo M and Wong IY:
The epithelial-mesenchymal transition and the cytoskeleton in
bioengineered systems. Cell Commun Signal. 19:322021. View Article : Google Scholar : PubMed/NCBI
|
38
|
Luo BP, Luo J, Hu YB, Yao XW and Wu FH:
Cyclin D1b splice variant promotes alphavbeta3-mediated EMT induced
by LPS in breast cancer cells. Curr Med Sci. 38:467–472. 2018.
View Article : Google Scholar : PubMed/NCBI
|
39
|
Liu T, Zhang J, Li K, Deng L and Wang H:
Combination of an autophagy inducer and an autophagy inhibitor: A
smarter strategy emerging in cancer therapy. Front Pharmacol.
11:4082020. View Article : Google Scholar : PubMed/NCBI
|
40
|
El-Khattouti A, Selimovic D, Haikel Y and
Hassan M: Crosstalk between apoptosis and autophagy: Molecular
mechanisms and therapeutic strategies in cancer. J Cell Death.
6:37–55. 2013. View Article : Google Scholar : PubMed/NCBI
|
41
|
Ding Y, Chen X, Liu C, Ge W, Wang Q, Hao
X, Wang M, Chen Y and Zhang Q: Identification of a small molecule
as inducer of ferroptosis and apoptosis through ubiquitination of
GPX4 in triple negative breast cancer cells. J Hematol Oncol.
14:192021. View Article : Google Scholar : PubMed/NCBI
|
42
|
Chen P, Wu Q, Feng J, Yan L, Sun Y, Liu S,
Xiang Y, Zhang M, Pan T, Chen X, et al: Erianin, a novel dibenzyl
compound in Dendrobium extract, inhibits lung cancer cell growth
and migration via calcium/calmodulin-dependent ferroptosis. Signal
Transduct Target Ther. 5:512020. View Article : Google Scholar : PubMed/NCBI
|
43
|
Zhou X, Zou L, Chen W, Yang T, Luo J, Wu
K, Shu F, Tan X, Yang Y, Cen S, et al: Flubendazole, FDA-approved
anthelmintic, elicits valid antitumor effects by targeting P53 and
promoting ferroptosis in castration-resistant prostate cancer.
Pharmacol Res. 164:1053052021. View Article : Google Scholar : PubMed/NCBI
|
44
|
Sun Y, Zheng Y, Wang C and Liu Y:
Glutathione depletion induces ferroptosis, autophagy, and premature
cell senescence in retinal pigment epithelial cells. Cell Death
Dis. 9:7532018. View Article : Google Scholar : PubMed/NCBI
|
45
|
Rastogi N, Gara RK, Trivedi R, Singh A,
Dixit P, Maurya R, Duggal S, Bhatt ML, Singh S and Mishra DP:
[6]-Gingerol induced myeloid leukemia cell death is initiated by
reactive oxygen species and activation of miR-27b expression. Free
Radic Biol Med. 68:288–301. 2014. View Article : Google Scholar : PubMed/NCBI
|
46
|
Nigam N, Bhui K, Prasad S, George J and
Shukla Y: [6]-Gingerol induces reactive oxygen species regulated
mitochondrial cell death pathway in human epidermoid carcinoma A431
cells. Chem Biol Interact. 181:77–84. 2009. View Article : Google Scholar : PubMed/NCBI
|
47
|
Mansingh DP, O JS, Sali VK and Vasanthi
HR: [6]-Gingerol-induced cell cycle arrest, reactive oxygen species
generation, and disruption of mitochondrial membrane potential are
associated with apoptosis in human gastric cancer (AGS) cells. J
Biochem Mol Toxicol. 32:e222062018. View Article : Google Scholar : PubMed/NCBI
|
48
|
Xie Y, Hou W, Song X, Yu Y, Huang J, Sun
X, Kang R and Tang D: Ferroptosis: process and function. Cell Death
Differ. 23:369–379. 2016. View Article : Google Scholar : PubMed/NCBI
|
49
|
Salazar M, Rojo AI, Velasco D, de Sagarra
RM and Cuadrado A: Glycogen synthase kinase-3beta inhibits the
xenobiotic and antioxidant cell response by direct phosphorylation
and nuclear exclusion of the transcription factor Nrf2. J Biol
Chem. 281:14841–14851. 2006. View Article : Google Scholar : PubMed/NCBI
|
50
|
Abusarah J, Benabdoune H, Shi Q, Lussier
B, Martel-Pelletier J, Malo M, Fernandes JC, de Souza FP, Fahmi H
and Benderdour M: Elucidating the Role of protandim and
[6]-gingerol in protection against osteoarthritis. J Cell Biochem.
118:1003–1013. 2017. View Article : Google Scholar : PubMed/NCBI
|
51
|
Wang Q, Wei Q, Yang Q, Cao X, Li Q, Shi F,
Tong SS, Feng C, Yu Q, Yu J and Xu X: A novel formulation of
[6]-gingerol: Proliposomes with enhanced oral bioavailability and
antitumor effect. Int J Pharm. 535:308–315. 2018. View Article : Google Scholar : PubMed/NCBI
|
52
|
Adetuyi BO and Farombi EO: 6-Gingerol, an
active constituent of ginger, attenuates lipopolysaccharide-induced
oxidation, inflammation, cognitive deficits, neuroplasticity, and
amyloidogenesis in rat. J Food Biochem. 45:e136602021. View Article : Google Scholar : PubMed/NCBI
|
53
|
de Lima RMT, Dos Reis AC, de Menezes APM,
Santos JVO, Filho J, Ferreira JRO, de Alencar M, da Mata A, Khan
IN, Islam A, et al: Protective and therapeutic potential of ginger
(Zingiber officinale) extract and [6]-gingerol in cancer: A
comprehensive review. Phytother Res. 32:1885–1907. 2018. View Article : Google Scholar : PubMed/NCBI
|