Open Access

Organic extract of Geodia cydonium induces cell cycle block in human mesothelioma cells

  • Authors:
    • Francesco Di Meo
    • Roberta Esposito
    • Rossana Cuciniello
    • Gregorio Favale
    • Mario Arenga
    • Nadia Ruocco
    • Genoveffa Nuzzo
    • Angelo Fontana
    • Stefania Filosa
    • Stefania Crispi
    • Maria Costantini
  • View Affiliations

  • Published online on: June 28, 2022     https://doi.org/10.3892/ol.2022.13406
  • Article Number: 286
  • Copyright: © Di Meo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The serious side effects caused by chemotherapeutics and the development of cancer chemoresistance represent the most significant limitations in the treatment of cancer. Some alternative approaches have been developed in recent years, which are based on natural compounds, and have allowed important advances in cancer therapeutics. During the last 50 years, sponges have been considered a promising source of natural products from the marine environment, representing ~30% of all marine natural products. Among sponges, the Mediterranean species Geodia cydonium represents a potential source of these type of products with considerable biotechnological interest as pharmaceutical agents. The present study demonstrated the antiproliferative effect of an organic G. cydonium extract (GEOCYDO) against three human mesothelioma cell lines, MSTO‑211H (MSTO), NCI‑H2452 (NCI) and Ist‑Mes2 (Mes2), which differ in their sensitivity (MSTO and NCI) and resistance (Mes2) to standard combined treatment with cisplatin and piroxicam. To this aim, the activity of the extract was evaluated by analyzing its effects on cell viability, cancer properties and cell cycle progression by means of colony formation assay, cell cycle analysis and protein expression analysis. The results revealed, in mesothelioma, this extract was able to reduce self‑renewal, cell migration and it could induce cell cycle arrest in G0/G1 stage, thus blocking cell proliferation. In conclusion, to the best of our knowledge, the present results indicated for the first time that GEOCYDO can contain active compounds able to affect cell proliferation in mesothelioma, suggesting that it could be considered as a potential novel drug source for cancer treatment.
View Figures
View References

Related Articles

Journal Cover

August-2022
Volume 24 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Di Meo F, Esposito R, Cuciniello R, Favale G, Arenga M, Ruocco N, Nuzzo G, Fontana A, Filosa S, Crispi S, Crispi S, et al: Organic extract of Geodia cydonium induces cell cycle block in human mesothelioma cells. Oncol Lett 24: 286, 2022.
APA
Di Meo, F., Esposito, R., Cuciniello, R., Favale, G., Arenga, M., Ruocco, N. ... Costantini, M. (2022). Organic extract of Geodia cydonium induces cell cycle block in human mesothelioma cells. Oncology Letters, 24, 286. https://doi.org/10.3892/ol.2022.13406
MLA
Di Meo, F., Esposito, R., Cuciniello, R., Favale, G., Arenga, M., Ruocco, N., Nuzzo, G., Fontana, A., Filosa, S., Crispi, S., Costantini, M."Organic extract of Geodia cydonium induces cell cycle block in human mesothelioma cells". Oncology Letters 24.2 (2022): 286.
Chicago
Di Meo, F., Esposito, R., Cuciniello, R., Favale, G., Arenga, M., Ruocco, N., Nuzzo, G., Fontana, A., Filosa, S., Crispi, S., Costantini, M."Organic extract of Geodia cydonium induces cell cycle block in human mesothelioma cells". Oncology Letters 24, no. 2 (2022): 286. https://doi.org/10.3892/ol.2022.13406