Open Access

Hesperidin inhibits tobacco smoke‑induced pulmonary cell proliferation and EMT in mouse lung tissues via the p38 signaling pathway

  • Authors:
    • Zhaofeng Liang
    • Yue Zhang
    • Yumeng Xu
    • Xinyi Zhang
    • Yanan Wang
  • View Affiliations

  • Published online on: November 29, 2022     https://doi.org/10.3892/ol.2022.13616
  • Article Number: 30
  • Copyright: © Liang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Tobacco smoke (TS) is the major cause of lung cancer. The abnormal proliferation and epithelial‑mesenchymal transition (EMT) of lung cells promote occurrence and development of lung cancer. The p38 pathway intervenes in this cancer development. Hesperidin also serves a role in human health and disease prevention. The roles of p38 in TS‑mediated abnormal cell proliferation and EMT, and the hesperidin intervention thereof are not yet understood. In the present study, it was demonstrated that TS upregulated proliferating cell nuclear antigen, vimentin and N‑cadherin expression, whereas it downregulated E‑cadherin expression, as assessed using western blotting and reverse transcription‑quantitative PCR. Furthermore, it was observed that inhibition of the p38 pathway inhibit TS‑induced proliferation and EMT. Hesperidin treatment prevented the TS‑induced activation of the p38 pathway, EMT and cell proliferation in mouse lungs. The findings of the present study may provide insights into the pathogenesis of TS‑related lung cancer.
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January-2023
Volume 25 Issue 1

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Copy and paste a formatted citation
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Spandidos Publications style
Liang Z, Zhang Y, Xu Y, Zhang X and Wang Y: Hesperidin inhibits tobacco smoke‑induced pulmonary cell proliferation and EMT in mouse lung tissues via the p38 signaling pathway. Oncol Lett 25: 30, 2023
APA
Liang, Z., Zhang, Y., Xu, Y., Zhang, X., & Wang, Y. (2023). Hesperidin inhibits tobacco smoke‑induced pulmonary cell proliferation and EMT in mouse lung tissues via the p38 signaling pathway. Oncology Letters, 25, 30. https://doi.org/10.3892/ol.2022.13616
MLA
Liang, Z., Zhang, Y., Xu, Y., Zhang, X., Wang, Y."Hesperidin inhibits tobacco smoke‑induced pulmonary cell proliferation and EMT in mouse lung tissues via the p38 signaling pathway". Oncology Letters 25.1 (2023): 30.
Chicago
Liang, Z., Zhang, Y., Xu, Y., Zhang, X., Wang, Y."Hesperidin inhibits tobacco smoke‑induced pulmonary cell proliferation and EMT in mouse lung tissues via the p38 signaling pathway". Oncology Letters 25, no. 1 (2023): 30. https://doi.org/10.3892/ol.2022.13616