Genetic variants of cancer‑associated genes analyzed using next‑generation sequencing in small sporadic vestibular schwannomas

  • Authors:
    • Takeshi Fujita
    • Kazuko Sakai
    • Natsumi Uehara
    • Yujiro Hoshi
    • Anjin Mori
    • Hajime Koyama
    • Mitsuo Sato
    • Kazuya Saito
    • Yasuhiro Osaki
    • Kazuto Nishio
    • Katsumi Doi
  • View Affiliations

  • Published online on: February 8, 2023     https://doi.org/10.3892/ol.2023.13707
  • Article Number: 121
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Vestibular schwannoma (VS) is the most common tumor of the cerebellopontine angle. Despite the increasing diagnosis of sporadic VS over the past decade, the use of traditional microsurgeries to treat VS has decreased. This is likely a result of the adoption of serial imaging as the most common initial evaluation and treatment strategy, especially for small‑sized VS. However, the pathobiology of VSs remains unclear, and elucidating the genetic information of tumor tissue may reveal novel insights. The present study performed a comprehensive genomic analysis of all exons in the key tumor suppressor and oncogenes from 10 small (<15 mm) sporadic VS samples. The evaluations identified NF2, SYNE1, IRS2, APC, CIC, SDHC, BRAF, NUMA1, EXT2, HRAS, BCL11B, MAGI1, RNF123, NLRP1, ASXL1, ADAMTS20, TAF1L, XPC, DDB2 and ETS1 as mutated genes. The current study could not draw any new conclusions about the relationship between VS‑related hearing loss and gene mutations; however, it did reveal that NF2 was the most frequently mutated gene in small sporadic VS.
View Figures
View References

Related Articles

Journal Cover

March-2023
Volume 25 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Fujita T, Sakai K, Uehara N, Hoshi Y, Mori A, Koyama H, Sato M, Saito K, Osaki Y, Nishio K, Nishio K, et al: Genetic variants of cancer‑associated genes analyzed using next‑generation sequencing in small sporadic vestibular schwannomas. Oncol Lett 25: 121, 2023
APA
Fujita, T., Sakai, K., Uehara, N., Hoshi, Y., Mori, A., Koyama, H. ... Doi, K. (2023). Genetic variants of cancer‑associated genes analyzed using next‑generation sequencing in small sporadic vestibular schwannomas. Oncology Letters, 25, 121. https://doi.org/10.3892/ol.2023.13707
MLA
Fujita, T., Sakai, K., Uehara, N., Hoshi, Y., Mori, A., Koyama, H., Sato, M., Saito, K., Osaki, Y., Nishio, K., Doi, K."Genetic variants of cancer‑associated genes analyzed using next‑generation sequencing in small sporadic vestibular schwannomas". Oncology Letters 25.3 (2023): 121.
Chicago
Fujita, T., Sakai, K., Uehara, N., Hoshi, Y., Mori, A., Koyama, H., Sato, M., Saito, K., Osaki, Y., Nishio, K., Doi, K."Genetic variants of cancer‑associated genes analyzed using next‑generation sequencing in small sporadic vestibular schwannomas". Oncology Letters 25, no. 3 (2023): 121. https://doi.org/10.3892/ol.2023.13707