Open Access

Vaginal and tumor microbiomes in gynecological cancer (Review)

  • Authors:
    • Mengzhen Han
    • Na Wang
    • Wenjie Han
    • Meng Ban
    • Tao Sun
    • Junnan Xu
  • View Affiliations

  • Published online on: March 3, 2023     https://doi.org/10.3892/ol.2023.13739
  • Article Number: 153
  • Copyright: © Han et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cervical, ovarian and endometrial cancer are the three most common types of gynecologic cancer. As a hub, the vagina connects the site of gynecological cancer with the external environment. Lactobacilli participate in the formation of a healthy vaginal microenvironment as the first line of defense against pathogen invasion; a dysbiotic vaginal microenvironment loses its original protective function and is associated with the onset, metastasis, poor efficacy and poor prognosis of gynecological cancer. The early diagnosis of cancer is the key to improve the survival time of patients with cancer. The screening of Porphyromonas, Sneathia and Atopobium vaginae, and other microbial markers, can assist the diagnosis of gynecological cancer, and screen out the high‑risk population as early as possible. With the in‑depth study of the microbes in tumor tissues, reasearchers have analyzed the immunological associations of microorganisms in tumor tissues. Due to the structural‑functional interconnection between the organ of gynecological tumorigenesis and the vagina, the present study aims to review the relationship between vaginal and tumor microorganisms and gynecological cancer in terms of occurrence, screening, treatment and prognosis.
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April-2023
Volume 25 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Han M, Wang N, Han W, Ban M, Sun T and Xu J: Vaginal and tumor microbiomes in gynecological cancer (Review). Oncol Lett 25: 153, 2023.
APA
Han, M., Wang, N., Han, W., Ban, M., Sun, T., & Xu, J. (2023). Vaginal and tumor microbiomes in gynecological cancer (Review). Oncology Letters, 25, 153. https://doi.org/10.3892/ol.2023.13739
MLA
Han, M., Wang, N., Han, W., Ban, M., Sun, T., Xu, J."Vaginal and tumor microbiomes in gynecological cancer (Review)". Oncology Letters 25.4 (2023): 153.
Chicago
Han, M., Wang, N., Han, W., Ban, M., Sun, T., Xu, J."Vaginal and tumor microbiomes in gynecological cancer (Review)". Oncology Letters 25, no. 4 (2023): 153. https://doi.org/10.3892/ol.2023.13739