Open Access

Comprehensive analysis reveals the value of the expression of chromobox family members for bladder urothelial carcinoma prognosis

  • Authors:
    • Xuan Meng
    • Runfu Cao
    • Xiaoqiang Liu
    • Bin Fu
    • Lianmin Luo
    • Meichun Jiang
    • Kaihong Wang
    • Yifu Liu
    • Qiqi Zhu
    • Chao Yang
    • Libo Zhou
  • View Affiliations

  • Published online on: March 14, 2023     https://doi.org/10.3892/ol.2023.13758
  • Article Number: 172
  • Copyright: © Meng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Bladder urothelial carcinoma (BLCA) accounts for 95% of all cases of bladder cancer worldwide, with a high incidence and poor prognosis. Chromobox (CBX) proteins play a key role in numerous malignant tumors; however, the role of CBX in BLCA remains unknown. Herein, the present study found that, compared with in normal bladder tissues, the expression levels of CBX1, CBX2, CBX3, CBX4 and CBX8 were markedly increased in BLCA tissues, as determined by Tumor Immune Estimation Resource, UALCAN and ONCOMINE analyses, whereas CBX6 and CBX7 were decreased in BLCA tissues. Furthermore, evident hypomethylation in the promoters of CBX1, and CBX2, as well as significant hypermethylation in the promoters of CBX5, CBX6 and CBX7, was detected in BLCA tissues compared with in normal bladder tissues. The expression of CBX1, CBX2 and CBX7 was involved in the prognosis of patients with BLCA. Low CBX7 expression was strongly associated with poorer overall survival in patients with BLCA, whereas high CBX1 and CBX2 expression was associated with poorer progression‑free survival. Besides, significant associations were determined between the expression of CBXs and immune cell infiltration, including dendritic cells, neutrophils, macrophages, CD4+ T cells, CD8+ T cells and B cells. Overall, the current results may provide a rationale for developing new targets and prognostic markers for BLCA therapy.
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April-2023
Volume 25 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Meng X, Cao R, Liu X, Fu B, Luo L, Jiang M, Wang K, Liu Y, Zhu Q, Yang C, Yang C, et al: Comprehensive analysis reveals the value of the expression of chromobox family members for bladder urothelial carcinoma prognosis. Oncol Lett 25: 172, 2023.
APA
Meng, X., Cao, R., Liu, X., Fu, B., Luo, L., Jiang, M. ... Zhou, L. (2023). Comprehensive analysis reveals the value of the expression of chromobox family members for bladder urothelial carcinoma prognosis. Oncology Letters, 25, 172. https://doi.org/10.3892/ol.2023.13758
MLA
Meng, X., Cao, R., Liu, X., Fu, B., Luo, L., Jiang, M., Wang, K., Liu, Y., Zhu, Q., Yang, C., Zhou, L."Comprehensive analysis reveals the value of the expression of chromobox family members for bladder urothelial carcinoma prognosis". Oncology Letters 25.4 (2023): 172.
Chicago
Meng, X., Cao, R., Liu, X., Fu, B., Luo, L., Jiang, M., Wang, K., Liu, Y., Zhu, Q., Yang, C., Zhou, L."Comprehensive analysis reveals the value of the expression of chromobox family members for bladder urothelial carcinoma prognosis". Oncology Letters 25, no. 4 (2023): 172. https://doi.org/10.3892/ol.2023.13758