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A giant breast malignant solitary fibrous tumor: A rare case report and brief review

  • Authors:
    • Yonghui Wang
    • Liquan Wang
    • Jinning Huang
    • Xiuping Liu
    • Huimin Sun
    • Xiaomei Sui
    • Xianglian Sun

  • View Affiliations

  • Published online on: April 26, 2023     https://doi.org/10.3892/ol.2023.13835
  • Article Number: 249

  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Solitary fibrous tumors (SFTs), which were first identified in the pleura and later at multiple anatomical locations, are rare mesenchymal neoplasms. The characteristics of SFTs include well‑circumscribed margins, intense vascularity and a relatively indolent clinical course. SFTs originating from the breast are rare. To the best of our knowledge, only 33 cases of breast SFTs, including five malignant tumors, have been reported to date. In the present study, a rare case of complete resection of a giant malignant SFT is reported. A 48‑year‑old female patient who visited Weifang People's Hospital (Weifang, China) had a 2‑year history of a right palpable breast lesion. The patient reported no other symptoms, such as skin changes or nipple discharge. An ultrasound examination revealed a giant, well‑circumscribed, heterogeneous and hypoechoic lesion with central and peripheral blood flow. Owing to the large size of the lesion, mammography and magnetic resonance imaging were not feasible. Core needle biology showed that the lesion was a malignant spindle cell tumor. Following this, mastectomy and sentinel lymph node biopsy were performed. The sentinel lymph nodes exhibited metastasis. A definitive diagnosis of malignant SFT was made by microscopic examination with immunohistochemistry. The treatment strategy for benign breast SFTs should be complete surgical excision, whereas for malignant SFTs, it should include radical resection along with radiotherapy and chemotherapy. Owing to the indolent nature and late recurrence and metastasis of malignant breast SFTs, regular patient follow‑up for a longer duration is essential.
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June-2023
Volume 25 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Wang Y, Wang L, Huang J, Liu X, Sun H, Sui X and Sun X: A giant breast malignant solitary fibrous tumor: A rare case report and brief review. Oncol Lett 25: 249, 2023.
APA
Wang, Y., Wang, L., Huang, J., Liu, X., Sun, H., Sui, X., & Sun, X. (2023). A giant breast malignant solitary fibrous tumor: A rare case report and brief review. Oncology Letters, 25, 249. https://doi.org/10.3892/ol.2023.13835
MLA
Wang, Y., Wang, L., Huang, J., Liu, X., Sun, H., Sui, X., Sun, X."A giant breast malignant solitary fibrous tumor: A rare case report and brief review". Oncology Letters 25.6 (2023): 249.
Chicago
Wang, Y., Wang, L., Huang, J., Liu, X., Sun, H., Sui, X., Sun, X."A giant breast malignant solitary fibrous tumor: A rare case report and brief review". Oncology Letters 25, no. 6 (2023): 249. https://doi.org/10.3892/ol.2023.13835