Open Access

CTHRC1, a novel gene with multiple functions in physiology, disease and solid tumors (Review)

  • Authors:
    • Ya-Juan Liu
    • Jing Du
    • Jie Li
    • Xiao-Ping Tan
    • Qing Zhang
  • View Affiliations

  • Published online on: May 3, 2023     https://doi.org/10.3892/ol.2023.13852
  • Article Number: 266
  • Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Collagen triple helix repeat containing 1 (CTHRC1) is a gene discovered in 2005; it is highly conserved, and no homologous proteins have been disclosed thus far. A number of studies have shown that CTHRC1 is present in normal tissues and organs, and it has vital functions in physiological processes, including participating in the regulation of metabolism, arterial remodeling, bone formation and myelination of the peripheral nervous system. It has been reported that abnormal expression of CTHRC1 is involved in the carcinogenesis of various human organs, such as the breast, colon, pancreas, lung, stomach and liver. Therefore, the present review aims to collate all known findings and results on the regulation of CTHRC1 expression and related signaling pathways. To conclude, this review also provides a hypothesis of the functional mechanism of this gene.
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June-2023
Volume 25 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Liu Y, Du J, Li J, Tan X and Zhang Q: CTHRC1, a novel gene with multiple functions in physiology, disease and solid tumors (Review). Oncol Lett 25: 266, 2023
APA
Liu, Y., Du, J., Li, J., Tan, X., & Zhang, Q. (2023). CTHRC1, a novel gene with multiple functions in physiology, disease and solid tumors (Review). Oncology Letters, 25, 266. https://doi.org/10.3892/ol.2023.13852
MLA
Liu, Y., Du, J., Li, J., Tan, X., Zhang, Q."CTHRC1, a novel gene with multiple functions in physiology, disease and solid tumors (Review)". Oncology Letters 25.6 (2023): 266.
Chicago
Liu, Y., Du, J., Li, J., Tan, X., Zhang, Q."CTHRC1, a novel gene with multiple functions in physiology, disease and solid tumors (Review)". Oncology Letters 25, no. 6 (2023): 266. https://doi.org/10.3892/ol.2023.13852