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MicroRNA‑153 may act as a potential biomarker and prognostic indicator of patients with gastric cancer

  • Authors:
    • Tian Li
    • Dong Guo
    • Xiaoyan Xu
    • Peng Liu
    • Ping Wang
    • Yongcun Zhu
    • Lin Lin
    • Yemin Qu
    • Feng Liu
    • Yanliu Chu
    • Xiaozhong Gao

  • View Affiliations

  • Published online on: May 12, 2023     https://doi.org/10.3892/ol.2023.13864
  • Article Number: 278

  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

MicroRNA (miR/miRNA)‑153, as a novel tumor‑related miRNA, has been found to be aberrantly expressed in different types of cancer; however, to the best of our knowledge, the role of miR‑153 in gastric cancer (GC) remains unclear. The present study demonstrated that miR‑153 expression was markedly decreased in GC, including GC cell lines and culture medium, GC tissues, and serum samples, based on reverse transcription‑quantitative PCR, and this was further confirmed by fluorescence in situ hybridization. Transfection with miR‑153 mimics inhibited proliferation and migration, and promoted apoptosis in GC cells. The serum expression levels of miR‑153 were decreased in 59 patients with GC compared with those of 9 healthy controls, and more decreased in advanced GC compared with early‑stage GC, suggesting that miR‑153 was associated with tumor progression. Furthermore, serum miR‑153 was expressed at significantly lower levels in patients with GC with larger tumor size (≥4 cm; P=0.013), poor differentiation and signet histology (P=0.013), lymph node metastasis (P=0.025) and advanced tumor stage (TNM stage III and IV; P=0.048) compared with patients with a smaller tumor size (<4 cm), well and moderate differentiation, no lymph node metastasis, and TNM stage I and II, respectively. In conclusion, the present study revealed that low miR‑153 expression was associated with poor prognosis in GC and miR‑153 may potentially act as a tumor biomarker and therapeutic target in GC.
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July-2023
Volume 26 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Li T, Guo D, Xu X, Liu P, Wang P, Zhu Y, Lin L, Qu Y, Liu F, Chu Y, Chu Y, et al: MicroRNA‑153 may act as a potential biomarker and prognostic indicator of patients with gastric cancer. Oncol Lett 26: 278, 2023.
APA
Li, T., Guo, D., Xu, X., Liu, P., Wang, P., Zhu, Y. ... Gao, X. (2023). MicroRNA‑153 may act as a potential biomarker and prognostic indicator of patients with gastric cancer. Oncology Letters, 26, 278. https://doi.org/10.3892/ol.2023.13864
MLA
Li, T., Guo, D., Xu, X., Liu, P., Wang, P., Zhu, Y., Lin, L., Qu, Y., Liu, F., Chu, Y., Gao, X."MicroRNA‑153 may act as a potential biomarker and prognostic indicator of patients with gastric cancer". Oncology Letters 26.1 (2023): 278.
Chicago
Li, T., Guo, D., Xu, X., Liu, P., Wang, P., Zhu, Y., Lin, L., Qu, Y., Liu, F., Chu, Y., Gao, X."MicroRNA‑153 may act as a potential biomarker and prognostic indicator of patients with gastric cancer". Oncology Letters 26, no. 1 (2023): 278. https://doi.org/10.3892/ol.2023.13864