Intraosseous synovial sarcoma of the mandible: A case report and review of the literature

Imajo,Ikumi; Yamada,Tomohiro; Chikui,Toru; Kiyoshima,Tamotsu; Ito,Mamoru; Kohashi,Kenichi; Sakamoto,Eiji; Oda,Yoshinao

doi:10.3892/ol.2023.13904

Intraosseous synovial sarcoma of the mandible: A case report and review of the literature

Authors:
- Ikumi Imajo
- Tomohiro Yamada
- Toru Chikui
- Tamotsu Kiyoshima
- Mamoru Ito
- Kenichi Kohashi
- Eiji Sakamoto
- Yoshinao Oda
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Affiliations: Section of Oral and Maxillofacial Surgery, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Higashi‑ku, Fukuoka 812‑8582, Japan, Oral and Maxillofacial Radiology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Higashi‑ku, Fukuoka 812‑8582, Japan, Laboratory of Oral Pathology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Higashi‑ku, Fukuoka 812‑8582, Japan, Department of Hematology, Oncology and Cardiovascular Medicine, Kyushu University Hospital, Higashi‑ku, Fukuoka 812‑8582, Japan, Department of Anatomic Pathology, Pathological Science, Graduate School of Medical Science, Kyushu University, Higashi‑ku, Fukuoka 812‑8582, Japan, Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Higashi‑ku, Fukuoka 812‑8582, Japan
Published online on: June 7, 2023 https://doi.org/10.3892/ol.2023.13904
Article Number: 318
Copyright : © Imajo et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

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Abstract

Synovial sarcoma (SS) is a malignant soft tissue tumor that usually arises in the para‑articular regions of the extremities. Only nine cases of SS in the mandible have been reported to date. The present study described a case of SS arising from the left mandible. A 54‑year‑old woman was referred to Kyushu University Hospital (Fukuoka, Japan) with a complaint of numbness in the left mental nerve area. Computed tomography revealed replacement of the left mandibular bone marrow with soft tissue and destruction of the mandibular canal. Magnetic resonance imaging revealed an isointense mass on T1‑weighted images and hyperintensity on T2‑weighted images. The tumor showed homogeneous enhancement. A biopsy was performed, and monophasic SS was diagnosed based on immunohistochemical staining features and genetic analysis. Hemimandible dissection and supraomophyoid neck resection were performed with fibular osteocutaneous flap reconstruction, followed by adjuvant chemotherapy. There was no evidence of recurrence or distant metastases. The present study also reviewed the clinical, imaging, histological, and immunohistochemical features of the SS in the mandible.

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1	Liu Z, Jin S, Fu S, Hu Y and He Y: Management of the primary intraosseous synovial sarcoma of the jaws: Be careful of the surgical margin. J Oral Maxillofac Surg. 73:550–563. 2015. View Article : Google Scholar : PubMed/NCBI
2	Gazendam AM, Popovic S, Munir S, Parasu N, Wilson D and Ghert M: Synovial sarcoma: A clinical review. Curr Oncol. 28:1909–1920. 2021. View Article : Google Scholar : PubMed/NCBI
3	Fiore M, Sambri A, Spinnato P, Zucchini R, Giannini C, Caldari E, Pirini MG and De Paolis M: The biology of synovial sarcoma: State-of-the-art and future perspectives. Curr Treat Options Oncol. 22:1092021. View Article : Google Scholar : PubMed/NCBI
4	Doubi A, Doubi M, Alzaher N and Tulbah A: Synovial sarcoma of the hard palate: The third case in the medical literature. Hematol Oncol Stem Cell Ther. 12:60–63. 2019. View Article : Google Scholar : PubMed/NCBI
5	WHO Classification of Tumours Editorial Board, . WHO classification of tumours of soft tissue and bone. 5th edition. IARC Press; Lyon, France: pp. 290–293. 2020
6	Knox LC: Synovial sarcoma. Am J Cancer Res. 28:461–480. 1936.
7	Landuzzi L, Ruzzi F, Lollini PL and Scotlandi K: Synovial sarcoma preclinical modeling: Integrating transgenic mouse models and patient-derived models for translational research. Cancers (Basel). 15:5882023. View Article : Google Scholar : PubMed/NCBI
8	Fujibuchi T, Miyawaki J, Kidani T, Imai H, Kiyomatsu H, Kitazawa R and Miura H: Intraosseous synovial sarcoma of the distal ulna: A case report and review of the literature. BMC Cancer. 19:1162019. View Article : Google Scholar : PubMed/NCBI
9	Caracciolo JT, Henderson-Jackson E and Binitie O: Synovial sarcoma of bone: Sarcoma typically of soft tissues presenting as a primary bone tumor. Radiol Case Rep. 14:204–207. 2018. View Article : Google Scholar : PubMed/NCBI
10	Torsiglieri AJ Jr, Hendrix RA and Quinn PS: Synovial sarcoma of the jaw. Ear Nose Throat J. 70:396–398. 1991.PubMed/NCBI
11	Koga C, Harada H, Kusukawa J and Kameyama T: Synovial sarcoma arising in the mandibular bone. Oral Oncol Extra. 41:45–48. 2005. View Article : Google Scholar
12	Granowetter L, Ladas E, Taromina K, Rooney D and Kelly KM; Integrative Tumor Board, : Integrative tumor board: Pediatric synovial sarcoma. Integr Cancer Ther. 5:48–55. 2006. View Article : Google Scholar : PubMed/NCBI
13	Tilakaratne WM: Synovial sarcoma of the mandible. J Oral Pathol Med. 35:61–63. 2006. View Article : Google Scholar : PubMed/NCBI
14	Wang H, Zhang J, He X and Niu Y: Synovial sarcoma in the oral and maxillofacial region: Report of 4 cases and review of the literature. J Oral Maxillofac Surg. 66:161–167. 2008. View Article : Google Scholar : PubMed/NCBI
15	Tao Q, Qiao B, Wang Y and Hu F: Diagnosis and treatment of primary synovial cell sarcoma that occurred in the left mandible body: A case report and literature review. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 111:e12–e20. 2011. View Article : Google Scholar : PubMed/NCBI
16	Wadhwan V, Malik S, Bhola N and Chaudhary M: Biphasic synovial sarcoma in mandibular region. J Oral Maxillofac Pathol. 15:239–243. 2011. View Article : Google Scholar : PubMed/NCBI
17	Khalili M, Eshghyar N, Ensani F and Shakib PA: Synovial sarcoma of the mandible. J Res Med Sci. 17:1082–1085. 2012.PubMed/NCBI
18	Teixeira LN, da Cruz EZ, Rosa ACG, Rodrigues AA, Passador-Santos F, de Araújo VC and Soares AB: Primary intraosseous synovial sarcoma in the mandible. Case Rep Oncol Med. 2021:99455912021.PubMed/NCBI
19	Saito T: The SYT-SSX fusion protein and histological epithelial differentiation in synovial sarcoma: Relationship with extracellular matrix remodeling. Int J Clin Exp Pathol. 6:2272–2279. 2013.PubMed/NCBI
20	Beck SE, Nielsen GP, Raskin KA and Schwab JH: Intraosseous synovial sarcoma of the proximal tibia. Int J Surg Oncol. 2011:1848912011.PubMed/NCBI
21	Kohashi K, Oda Y, Yamamoto H, Tamiya S, Matono H, Iwamoto Y, Taguchi T and Tsuneyoshi M: Reduced expression of SMARCB1/INI1 protein in synovial sarcoma. Mod Pathol. 23:981–990. 2010. View Article : Google Scholar : PubMed/NCBI
22	Kadoch C and Crabtree GR: Reversible disruption of mSWI/SNF (BAF) complexes by the SS18-SSX oncogenic fusion in synovial sarcoma. Cell. 153:71–85. 2013. View Article : Google Scholar : PubMed/NCBI
23	Salcedo-Hernández RA, Lino-Silva LS and Luna-Ortiz K: Synovial sarcomas of the head and neck: Comparative analysis with synovial sarcoma of the extremities. Auris Nasus Larynx. 40:476–480. 2013. View Article : Google Scholar : PubMed/NCBI
24	López-Pousa A, Martin Broto J, Martinez Trufero J, Sevilla I, Valverde C, Alvarez R, Carrasco Alvarez JA, Cruz Jurado J, Hindi N and Garcia Del Muro X: SEOM clinical guideline of management of soft-tissue sarcoma (2016). Clin Transl Oncol. 18:1213–1220. 2016. View Article : Google Scholar : PubMed/NCBI