Open Access

Emerging roles of circ_NRIP1 in tumor development and cancer therapy (Review)

  • Authors:
    • Xin Gao
    • Yongbo Yu
    • Haicun Wang
    • Guanglin Liu
    • Xinyu Sun
    • Zhidong Wang
    • Xingming Jiang
  • View Affiliations

  • Published online on: June 8, 2023     https://doi.org/10.3892/ol.2023.13907
  • Article Number: 321
  • Copyright: © Gao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Circular RNA (circRNA) is a class of endogenous non‑coding RNA, a type of single‑stranded covalently closed RNA molecule formed by alternative splicing of exons or introns. Previous studies have demonstrated that circRNA participates in modulating biological processes such as cell proliferation, differentiation and apoptosis, and plays key roles in tumor occurrence and development. CircRNA nuclear receptor interacting protein 1 (circ_NRIP1), a form of circRNA, is abnormally expressed in certain human tumor types. It is present at a higher abundance compared with cognate linear transcripts and can regulate malignant biological behaviors such as tumor proliferation, invasion and migration, revealing a currently unexplored frontier in cancer progression. The present review presents a pattern of circ_NRIP1 expression in various malignant tumor types and highlights its significance in cancer development, in addition to its potential as a disease indicator or future therapeutic agent.
View Figures
View References

Related Articles

Journal Cover

July-2023
Volume 26 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Gao X, Yu Y, Wang H, Liu G, Sun X, Wang Z and Jiang X: Emerging roles of circ_NRIP1 in tumor development and cancer therapy (Review). Oncol Lett 26: 321, 2023
APA
Gao, X., Yu, Y., Wang, H., Liu, G., Sun, X., Wang, Z., & Jiang, X. (2023). Emerging roles of circ_NRIP1 in tumor development and cancer therapy (Review). Oncology Letters, 26, 321. https://doi.org/10.3892/ol.2023.13907
MLA
Gao, X., Yu, Y., Wang, H., Liu, G., Sun, X., Wang, Z., Jiang, X."Emerging roles of circ_NRIP1 in tumor development and cancer therapy (Review)". Oncology Letters 26.1 (2023): 321.
Chicago
Gao, X., Yu, Y., Wang, H., Liu, G., Sun, X., Wang, Z., Jiang, X."Emerging roles of circ_NRIP1 in tumor development and cancer therapy (Review)". Oncology Letters 26, no. 1 (2023): 321. https://doi.org/10.3892/ol.2023.13907