Application of pyroptosis in tumor research (Review)
- Authors:
- Jianing Tan
- Ziliang Zhuo
- Yu Si
-
Affiliations: Department of Neurology, Changshu No. 2 People's Hospital, Affiliated Changshu Hospital of Nantong University, Suzhou, Jiangsu 215500, P.R. China, Basic Research Laboratory, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, P.R. China - Published online on: July 18, 2023 https://doi.org/10.3892/ol.2023.13962
- Article Number: 376
-
Copyright: © Tan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
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Abstract
 |
|
Fan J, Feng Z and Chen N: Spermidine as a target for cancer therapy. Pharmacol Res. 159:1049432020. View Article : Google Scholar : PubMed/NCBI | |
|
Carioli G, Malvezzi M, Bertuccio P, Hashim D, Waxman S, Negri E, Boffetta P and La Vecchia C: Cancer mortality in the elderly in 11 countries worldwide, 1970–2015. Ann Oncol. 30:1344–1355. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Mattiuzzi C and Lippi G: Current cancer epidemiology. J Epidemiol Glob Health. 9:217–222. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Yang Y: Cancer immunotherapy: Harnessing the immune system to battle cancer. J Clin Invest. 125:3335–3337. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Cha JH, Chan LC, Li CW, Hsu JL and Hung MC: Mechanisms controlling PD-L1 expression in cancer. Mol Cell. 76:359–370. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Rowshanravan B, Halliday N and Sansom DM: CTLA-4: A moving target in immunotherapy. Blood. 131:58–67. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Jiang H, Shi Z, Wang P, Wang C, Yang L, Du G, Zhang H, Shi B, Jia J, Li Q, et al: Claudin18.2-specific chimeric antigen receptor engineered T cells for the treatment of gastric Cancer. J Natl Cancer Inst. 111:409–418. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Christgen S, Tweedell RE and Kanneganti TD: Programming inflammatory cell death for therapy. Pharmacol Ther. 232:1080102022. View Article : Google Scholar : PubMed/NCBI | |
|
Fang Y, Tian S, Pan Y, Li W, Wang Q, Tang Y, Yu T, Wu X, Shi Y, Ma P and Shu Y: Pyroptosis: A new frontier in cancer. Biomed Pharmacother. 121:1095952020. View Article : Google Scholar : PubMed/NCBI | |
|
Loveless R, Bloomquist R and Teng Y: Pyroptosis at the forefront of anticancer immunity. J Exp Clin Cancer Res. 40:2642021. View Article : Google Scholar : PubMed/NCBI | |
|
Duan Q, Zhang H, Zheng J and Zhang L: Turning cold into hot: Firing up the tumor microenvironment. Trends Cancer. 6:605–618. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Niu X, Chen L, Li Y, Hu Z and He F: Ferroptosis, necroptosis, and pyroptosis in the tumor microenvironment: Perspectives for immunotherapy of SCLC. Semin Cancer Biol. 86:273–285. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Rioja-Blanco E, Arroyo-Solera I, Álamo P, Casanova I, Gallardo A, Unzueta U, Serna N, Sánchez-García L, Quer M, Villaverde A, et al: CXCR4-targeted nanotoxins induce GSDME-dependent pyroptosis in head and neck squamous cell carcinoma. J Exp Clin Cancer Res. 41:492022. View Article : Google Scholar : PubMed/NCBI | |
|
Liu Y, Guo K, Ding M, Zhang B, Xiao N, Tang Z, Wang Z, Zhang C and Shubhra QTH: Engineered magnetic polymer nanoparticles can ameliorate breast cancer treatment inducing pyroptosis-starvation along with chemotherapy. ACS Appl Mater Interfaces. 14:42541–42557. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Wu D, Wang S, Yu G and Chen X: Cell death mediated by the pyroptosis pathway with the aid of nanotechnology: Prospects for cancer therapy. Angew Chem Int Ed Engl. 60:8018–8034. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Gogoi M, Shreenivas MM and Chakravortty D: Hoodwinking the big-eater to prosper: The salmonella-macrophage paradigm. J Innate Immun. 11:289–299. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Zychlinsky A, Prevost MC and Sansonetti PJ: Shigella flexneri induces apoptosis in infected macrophages. Nature. 358:167–169. 1992. View Article : Google Scholar : PubMed/NCBI | |
|
Hu X, Chen H, Xu H, Wu Y, Wu C, Jia C, Li Y, Sheng S, Xu C, Xu H, et al: Role of pyroptosis in traumatic brain and spinal cord injuries. Int J Biol Sci. 16:2042–2050. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Carneiro BA and El-Deiry WS: Targeting apoptosis in cancer therapy. Nat Rev Clin Oncol. 17:395–417. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
D'Souza CA and Heitman J: Dismantling the cryptococcus coat. Trends Microbiol. 9:112–113. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Xia X, Wang X, Cheng Z, Qin W, Lei L, Jiang J and Hu J: The role of pyroptosis in cancer: pro-cancer or pro-‘host’? Cell Death Dis. 10:6502019. View Article : Google Scholar : PubMed/NCBI | |
|
Xu YJ, Zheng L, Hu YW and Wang Q: Pyroptosis and its relationship to atherosclerosis. Clin Chim Acta. 476:28–37. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Xia S, Zhang Z, Magupalli VG, Pablo JL, Dong Y, Vora SM, Wang L, Fu TM, Jacobson MP, Greka A, et al: Gasdermin D pore structure reveals preferential release of mature interleukin-1. Nature. 593:607–611. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Burdette BE, Esparza AN, Zhu H and Wang S: Gasdermin D in pyroptosis. Acta Pharm Sin B. 11:2768–2782. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Broz P, Pelegrín P and Shao F: The gasdermins, a protein family executing cell death and inflammation. Nat Rev Immunol. 20:143–157. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Fischer FA, Chen KW and Bezbradica JS: Posttranslational and therapeutic control of gasdermin-mediated pyroptosis and inflammation. Front Immunol. 12:6611622021. View Article : Google Scholar : PubMed/NCBI | |
|
Van Opdenbosch N and Lamkanfi M: Caspases in cell death, inflammation, and disease. Immunity. 50:1352–1364. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Man SM and Kanneganti TD: Regulation of inflammasome activation. Immunol Rev. 265:6–21. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Cai X, Chen J, Xu H, Liu S, Jiang QX, Halfmann R and Chen ZJ: Prion-like polymerization underlies signal transduction in antiviral immune defense and inflammasome activation. Cell. 156:1207–1222. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Shao S, Chen C, Shi G, Zhou Y, Wei Y, Fan N, Yang Y, Wu L and Zhang T: Therapeutic potential of the target on NLRP3 inflammasome in multiple sclerosis. Pharmacol Ther. 227:1078802021. View Article : Google Scholar : PubMed/NCBI | |
|
Lahooti B, Chhibber T, Bagchi S, Varahachalam SP and Jayant RD: Therapeutic role of inflammasome inhibitors in neurodegenerative disorders. Brain Behav Immun. 91:771–783. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Li S, Wang L, Xu Z, Huang Y, Xue R, Yue T, Xu L, Gong F, Bai S, Wu Q, et al: ASC deglutathionylation is a checkpoint for NLRP3 inflammasome activation. J Exp Med. 218:e202026372021. View Article : Google Scholar : PubMed/NCBI | |
|
Wang C, Yang T, Xiao J, Xu C, Alippe Y, Sun K, Kanneganti TD, Monahan JB, Abu-Amer Y, Lieberman J and Mbalaviele G: NLRP3 inflammasome activation triggers gasdermin D-independent inflammation. Sci Immunol. 6:eabj38592021. View Article : Google Scholar : PubMed/NCBI | |
|
He Y, Hara H and Núñez G: Mechanism and regulation of NLRP3 inflammasome activation. Trends Biochem Sci. 41:1012–1021. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Zheng M and Kanneganti TD: The regulation of the ZBP1-NLRP3 inflammasome and its implications in pyroptosis, apoptosis, and necroptosis (PANoptosis). Immunol Rev. 297:26–38. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Swanson KV, Deng M and Ting JPY: The NLRP3 inflammasome: Molecular activation and regulation to therapeutics. Nat Rev Immunol. 19:477–489. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Teng JF, Mei QB, Zhou XG, Tang Y, Xiong R, Qiu WQ, Pan R, Law BYK, Wong VKW, Yu CL, et al: Polyphyllin VI induces caspase-1-mediated pyroptosis via the induction of ROS/NF-κB/NLRP3/GSDMD signal axis in non-small cell lung cancer. Cancers (Basel). 12:1932020. View Article : Google Scholar : PubMed/NCBI | |
|
Ershaid N, Sharon Y, Doron H, Raz Y, Shani O, Cohen N, Monteran L, Leider-Trejo L, Ben-Shmuel A, Yassin M, et al: NLRP3 inflammasome in fibroblasts links tissue damage with inflammation in breast cancer progression and metastasis. Nat Commun. 10:43752019. View Article : Google Scholar : PubMed/NCBI | |
|
Li T, Fu B, Zhang X, Zhou Y, Yang M, Cao M, Chen Y, Tan Y and Hu R: Overproduction of gastrointestinal 5-HT promotes colitis-associated colorectal cancer progression via enhancing NLRP3 inflammasome activation. Cancer Immunol Res. 9:1008–1023. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Hsu SK, Li CY, Lin IL, Syue WJ, Chen YF, Cheng KC, Teng YN, Lin YH, Yen CH and Chiu CC: Inflammation-related pyroptosis, a novel programmed cell death pathway, and its crosstalk with immune therapy in cancer treatment. Theranostics. 11:8813–8835. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
He X, Fan X, Bai B, Lu N, Zhang S and Zhang L: Pyroptosis is a critical immune-inflammatory response involved in atherosclerosis. Pharmacol Res. 165:1054472021. View Article : Google Scholar : PubMed/NCBI | |
|
Zheng X, Chen W, Gong F, Chen Y and Chen E: The role and mechanism of pyroptosis and potential therapeutic targets in sepsis: A review. Front Immunol. 12:7119392021. View Article : Google Scholar : PubMed/NCBI | |
|
Wright SS, Vasudevan SO and Rathinam VA: Mechanisms and consequences of noncanonical inflammasome-mediated pyroptosis. J Mol Biol. 434:1672452022. View Article : Google Scholar : PubMed/NCBI | |
|
Burzynski LC and Clarke MCH: Death is coming and the clot thickens, as pyroptosis feeds the fire. Immunity. 50:1339–1341. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Kayagaki N, Warming S, Lamkanfi M, Vande Walle L, Louie S, Dong J, Newton K, Qu Y, Liu J, Heldens S, et al: Non-canonical inflammasome activation targets caspase-11. Nature. 479:117–121. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Xia S, Hollingsworth LR IV and Wu H: Mechanism and regulation of gasdermin-mediated cell death. Cold Spring Harb Perspect Biol. 12:a0364002020. View Article : Google Scholar : PubMed/NCBI | |
|
Deng W, Bai Y, Deng F, Pan Y, Mei S, Zheng Z, Min R, Wu Z, Li W, Miao R, et al: Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis. Nature. 602:496–502. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
LaRock DL, Johnson AF, Wilde S, Sands JS, Monteiro MP and LaRock CN: Group A streptococcus induces GSDMA-dependent pyroptosis in keratinocytes. Nature. 605:527–531. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Zhou Z, He H, Wang K, Shi X, Wang Y, Su Y, Wang Y, Li D, Liu W, Zhang Y, et al: Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells. Science. 368:eaaz75482020. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang JY, Zhou B, Sun RY, Ai YL, Cheng K, Li FN, Wang BR, Liu FJ, Jiang ZH, Wang WJ, et al: The metabolite α-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8. Cell Res. 31:980–997. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Wang K, Sun Q, Zhong X, Zeng M, Zeng H, Shi X, Li Z, Wang Y, Zhao Q, Shao F and Ding J: Structural mechanism for GSDMD targeting by autoprocessed caspases in pyroptosis. Cell. 180:941–955.e20. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Wang Y, Gao W, Shi X, Ding J, Liu W, He H, Wang K and Shao F: Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin. Nature. 547:99–103. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Barnett KC and Ting JPY: Mitochondrial GSDMD pores DAMPen pyroptosis. Immunity. 52:424–426. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Liu Z, Gan L, Xu Y, Luo D, Ren Q, Wu S and Sun C: Melatonin alleviates inflammasome-induced pyroptosis through inhibiting NF-κB/GSDMD signal in mice adipose tissue. J Pineal Res. 63:2017. View Article : Google Scholar | |
|
Humphries F, Shmuel-Galia L, Ketelut-Carneiro N, Li S, Wang B, Nemmara VV, Wilson R, Jiang Z, Khalighinejad F, Muneeruddin K, et al: Succination inactivates gasdermin D and blocks pyroptosis. Science. 369:1633–1637. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Yi YS: Regulatory roles of the caspase-11 non-canonical inflammasome in inflammatory diseases. Immune Netw. 18:e412018. View Article : Google Scholar : PubMed/NCBI | |
|
Yu P, Zhang X, Liu N, Tang L, Peng C and Chen X: Pyroptosis: Mechanisms and diseases. Signal Transduct Target Ther. 6:1282021. View Article : Google Scholar : PubMed/NCBI | |
|
Tang D, Kang R, Berghe TV, Vandenabeele P and Kroemer G: The molecular machinery of regulated cell death. Cell Res. 29:347–364. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Yan HF, Zou T, Tuo QZ, Xu S, Li H, Belaidi AA and Lei P: Ferroptosis: Mechanisms and links with diseases. Signal Transduct Target Ther. 6:492021. View Article : Google Scholar : PubMed/NCBI | |
|
Bertheloot D, Latz E and Franklin BS: Necroptosis, pyroptosis and apoptosis: An intricate game of cell death. Cell Mol Immunol. 18:1106–1121. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Hanahan D and Weinberg RA: Hallmarks of cancer: The next generation. Cell. 144:646–674. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Rao Z, Zhu Y, Yang P, Chen Z, Xia Y, Qiao C, Liu W, Deng H, Li J, Ning P and Wang Z: Pyroptosis in inflammatory diseases and cancer. Theranostics. 12:4310–4329. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Yan H, Luo B, Wu X, Guan F, Yu X, Zhao L, Ke X, Wu J and Yuan J: Cisplatin induces pyroptosis via activation of MEG3/NLRP3/caspase-1/GSDMD pathway in triple-negative breast cancer. Int J Biol Sci. 17:2606–2621. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Yuan R, Zhao W, Wang QQ, He J, Han S, Gao H, Feng Y and Yang S: Cucurbitacin B inhibits non-small cell lung cancer in vivo and in vitro by triggering TLR4/NLRP3/GSDMD-dependent pyroptosis. Pharmacol Res. 170:1057482021. View Article : Google Scholar : PubMed/NCBI | |
|
Yu J, Li S, Qi J, Chen Z, Wu Y, Guo J, Wang K, Sun X and Zheng J: Cleavage of GSDME by caspase-3 determines lobaplatin-induced pyroptosis in colon cancer cells. Cell Death Dis. 10:1932019. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang Z, Zhang Y, Xia S, Kong Q, Li S, Liu X, Junqueira C, Meza-Sosa KF, Mok TMY, Ansara J, et al: Gasdermin E suppresses tumour growth by activating anti-tumour immunity. Nature. 579:415–420. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Ibrahim J, De Schutter E and Op de Beeck K: GSDME: A potential ally in cancer detection and treatment. Trends Cancer. 7:392–394. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Jia Y, Wang X, Deng Y, Li S, Xu X, Qin Y and Peng L: Pyroptosis provides new strategies for the treatment of cancer. J Cancer. 14:140–151. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Jiang M, Qi L, Li L and Li Y: The caspase-3/GSDME signal pathway as a switch between apoptosis and pyroptosis in cancer. Cell Death Discov. 6:1122020. View Article : Google Scholar : PubMed/NCBI | |
|
Carlino MS, Larkin J and Long GV: Immune checkpoint inhibitors in melanoma. Lancet. 398:1002–1014. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Lou X, Li K, Qian B, Li Y, Zhang D and Cui W: Pyroptosis correlates with tumor immunity and prognosis. Commun Biol. 5:9172022. View Article : Google Scholar : PubMed/NCBI | |
|
Li S, Chen P, Cheng B, Liu Y, Zhang X, Xu Q, Huang M, Dai X, Huang K, Zhang L, et al: Pyroptosis predicts immunotherapy outcomes across multiple cancer types. Clin Immunol. 245:1091632022. View Article : Google Scholar : PubMed/NCBI | |
|
Gao W, Wang X, Zhou Y, Wang X and Yu Y: Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy. Signal Transduct Target Ther. 7:1962022. View Article : Google Scholar : PubMed/NCBI | |
|
Krysko DV, Garg AD, Kaczmarek A, Krysko O, Agostinis P and Vandenabeele P: Immunogenic cell death and DAMPs in cancer therapy. Nat Rev Cancer. 12:860–875. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Galluzzi L, Vitale I, Warren S, Adjemian S, Agostinis P, Martinez AB, Chan TA, Coukos G, Demaria S, Deutsch E, et al: Consensus guidelines for the definition, detection and interpretation of immunogenic cell death. J Immunother Cancer. 8:e0003372020. View Article : Google Scholar : PubMed/NCBI | |
|
Yatim N, Jusforgues-Saklani H, Orozco S, Schulz O, Barreira da Silva R, Reis e Sousa C, Green DR, Oberst A and Albert ML: RIPK1 and NF-κB signaling in dying cells determines cross-priming of CD8+ T cells. Science. 350:328–334. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Chen DS and Mellman I: Oncology meets immunology: The cancer-immunity cycle. Immunity. 39:1–10. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Zeng C, Wang R and Tan H: Role of pyroptosis in cardiovascular diseases and its therapeutic implications. Int J Biol Sci. 15:1345–1357. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Song M, Cui M and Liu K: Therapeutic strategies to overcome cisplatin resistance in ovarian cancer. Eur J Med Chem. 232:1142052022. View Article : Google Scholar : PubMed/NCBI | |
|
Aloss K and Hamar P: Recent preclinical and clinical progress in liposomal doxorubicin. Pharmaceutics. 15:8932023. View Article : Google Scholar : PubMed/NCBI | |
|
Vasan N, Baselga J and Hyman DM: A view on drug resistance in cancer. Nature. 575:299–309. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang Z, Zhang H, Li D, Zhou X, Qin Q and Zhang Q: Caspase-3-mediated GSDME induced pyroptosis in breast cancer cells through the ROS/JNK signalling pathway. J Cell Mol Med. 25:8159–8168. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Ghosh S: Cisplatin: The first metal based anticancer drug. Bioorg Chem. 88:1029252019. View Article : Google Scholar : PubMed/NCBI | |
|
Stater EP, Sonay AY, Hart C and Grimm J: The ancillary effects of nanoparticles and their implications for nanomedicine. Nat Nanotechnol. 16:1180–1194. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Kirtane AR, Verma M, Karandikar P, Furin J, Langer R and Traverso G: Nanotechnology approaches for global infectious diseases. Nat Nanotechnol. 16:369–384. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Ploetz E, Zimpel A, Cauda V, Bauer D, Lamb DC, Haisch C, Zahler S, Vollmar AM, Wuttke S and Engelke H: Metal-organic framework nanoparticles induce pyroptosis in cells controlled by the extracellular pH. Adv Mater. 32:e19072672020. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang Y, Yu W, Chen M, Zhang B, Zhang L and Li P: The applications of nanozymes in cancer therapy: Based on regulating pyroptosis, ferroptosis and autophagy of tumor cells. Nanoscale. Jun 28–2023.(Epub ahead of print). View Article : Google Scholar | |
|
Yang F, Bettadapura SN, Smeltzer MS, Zhu H and Wang S: Pyroptosis and pyroptosis-inducing cancer drugs. Acta Pharmacol Si. 43:2462–2473. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Wu D, Zhu X, Ao J, Song E and Song Y: Delivery of ultrasmall nanoparticles to the cytosolic compartment of pyroptotic J774A.1 macrophages via GSDMDNterm membrane pores. ACS Appl Mater Interfaces. 13:50823–50835. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Zhao P, Wang M, Chen M, Chen Z, Peng X, Zhou F, Song J and Qu J: Programming cell pyroptosis with biomimetic nanoparticles for solid tumor immunotherapy. Biomaterials. 254:1201422020. View Article : Google Scholar : PubMed/NCBI | |
|
Kuchur OA, Tsymbal SA, Shestovskaya MV, Serov NS, Dukhinova MS and Shtil AA: Metal-derived nanoparticles in tumor theranostics: Potential and limitations. J Inorg Biochem. 209:1111172020. View Article : Google Scholar : PubMed/NCBI | |
|
Cui R, Wu Q, Wang J, Zheng X, Ou R, Xu Y, Qu S and Li D: Hydrogel-by-design: Smart delivery system for cancer immunotherapy. Front Bioeng Biotechnol. 9:7234902021. View Article : Google Scholar : PubMed/NCBI | |
|
Guimarães CF, Ahmed R, Marques AP, Reis RL and Demirci U: Engineering hydrogel-based biomedical photonics: Design, fabrication, and applications. Adv Mater. 33:e20065822021. View Article : Google Scholar : PubMed/NCBI | |
|
Yin Y, Li X, Ma H, Zhang J, Yu D, Zhao R, Yu S, Nie G and Wang H: In situ transforming RNA nanovaccines from polyethylenimine functionalized graphene oxide hydrogel for durable cancer immunotherapy. Nano Lett. 21:2224–2231. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Sepantafar M, Maheronnaghsh R, Mohammadi H, Radmanesh F, Hasani-Sadrabadi MM, Ebrahimi M and Baharvand H: Engineered hydrogels in cancer therapy and diagnosis. Trends Biotechnol. 35:1074–1087. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Guedes G, Wang S, Fontana F, Figueiredo P, Lindén J, Correia A, Pinto RJB, Hietala S, Sousa FL and Santos HA: Dual-crosslinked dynamic hydrogel incorporating {Mo154} with pH and NIR responsiveness for chemo-photothermal therapy. Adv Mater. 33:e20077612021. View Article : Google Scholar : PubMed/NCBI | |
|
Guan QF, Yang HB, Han ZM, Ling ZC, Yin CH, Yang KP, Zhao YX and Yu SH: Sustainable cellulose-nanofiber-based hydrogels. ACS Nano. 15:7889–7898. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Basti ATK, Jonoobi M, Sepahvand S, Ashori A, Siracusa V, Rabie D, Mekonnen TH and Naeijian F: Employing cellulose nanofiber-based hydrogels for burn dressing. Polymers (Basel). 14:12072022. View Article : Google Scholar : PubMed/NCBI | |
|
Balahura LR, Dinescu S, Balaș M, Cernencu A, Lungu A, Vlăsceanu GM, Iovu H and Costache M: Cellulose nanofiber-based hydrogels embedding 5-FU promote pyroptosis activation in breast cancer cells and support human adipose-derived stem cell proliferation, opening new perspectives for breast tissue engineering. Pharmaceutics. 13:11892021. View Article : Google Scholar : PubMed/NCBI | |
|
Gonsalves A, Tambe P, Le D, Thakore D, Wadajkar AS, Yang J, Nguyen KT and Menon JU: Synthesis and characterization of a novel pH-responsive drug-releasing nanocomposite hydrogel for skin cancer therapy and wound healing. J Mater Chem B. 9:9533–9546. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Wang S, Zhang Z, Wei S, He F, Li Z, Wang HH, Huang Y and Nie Z: Near-infrared light-controllable MXene hydrogel for tunable on-demand release of therapeutic proteins. Acta Biomater. 130:138–148. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Zheng Y, Wang W, Zhao J, Wu C, Ye C, Huang M and Wang S: Preparation of injectable temperature-sensitive chitosan-based hydrogel for combined hyperthermia and chemotherapy of colon cancer. Carbohydr Polym. 222:1150392019. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang W, Jin X, Li H, Zhang RR and Wu CW: Injectable and body temperature sensitive hydrogels based on chitosan and hyaluronic acid for pH sensitive drug release. Carbohydr Polym. 186:82–90. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Phan VHG, Murugesan M, Huong H, Le TT, Phan TH, Manivasagan P, Mathiyalagan R, Jang ES, Yang DC, Li Y and Thambi T: Cellulose nanocrystals-incorporated thermosensitive hydrogel for controlled release, 3D printing, and breast cancer treatment applications. ACS Appl Mater Interfaces. 14:42812–42826. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Kim J, Francis DM, Sestito LF, Archer PA, Manspeaker MP, O'Melia MJ and Thomas SN: Thermosensitive hydrogel releasing nitric oxide donor and anti-CTLA-4 micelles for anti-tumor immunotherapy. Nat Commun. 13:14792022. View Article : Google Scholar : PubMed/NCBI | |
|
Robinson N, Ganesan R, Hegedűs C, Kovács K, Kufer TA and Virág L: Programmed necrotic cell death of macrophages: Focus on pyroptosis, necroptosis, and parthanatos. Redox Biol. 26:1012392019. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang Y, Chen X, Gueydan C and Han J: Plasma membrane changes during programmed cell deaths. Cell Res. 28:9–21. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Ding J, Wang K, Liu W, She Y, Sun Q, Shi J, Sun H, Wang DC and Shao F: Pore-forming activity and structural autoinhibition of the gasdermin family. Nature. 535:111–116. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Liu X, Zhang Z, Ruan J, Pan Y, Magupalli VG, Wu H and Lieberman J: Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores. Nature. 535:153–158. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Wei X, Xie F, Zhou X, Wu Y, Yan H, Liu T, Huang J, Wang F, Zhou F and Zhang L: Role of pyroptosis in inflammation and cancer. Cell Mol Immunol. 19:971–992. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Liu Z, Wang T, She Y, Wu K, Gu S, Li L, Dong C, Chen C and Zhou Y: N6-methyladenosine-modified circIGF2BP3 inhibits CD8+ T-cell responses to facilitate tumor immune evasion by promoting the deubiquitination of PD-L1 in non-small cell lung cancer. Mol Cancer. 20:1052021. View Article : Google Scholar : PubMed/NCBI | |
|
Xia R, Geng G, Yu X, Xu Z, Guo J, Liu H, Li N, Li Z, Li Y, Dai X, et al: LINC01140 promotes the progression and tumor immune escape in lung cancer by sponging multiple microRNAs. J Immunother Cancer. 9:e0027462021. View Article : Google Scholar : PubMed/NCBI | |
|
Hou J, Hsu JM and Hung MC: Molecular mechanisms and functions of pyroptosis in inflammation and antitumor immunity. Mol Cell. 81:4579–4590. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Wei Y, Yang L, Pandeya A, Cui J, Zhang Y and Li Z: Pyroptosis-induced inflammation and tissue damage. J Mol Biol. 434:1673012022. View Article : Google Scholar : PubMed/NCBI |
