Open Access

Advances in transcriptomics and proteomics in differentiated thyroid cancer: An updated perspective (Review)

  • Authors:
    • Shici Yang
    • Gaohong Zhu
    • Rui He
    • Dong Fang
    • Jiaojiao Feng
  • View Affiliations

  • Published online on: July 27, 2023     https://doi.org/10.3892/ol.2023.13982
  • Article Number: 396
  • Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Thyroid cancer (TC) is a broad classification of neoplasms that includes differentiated thyroid cancer (DTC) as a common histological subtype. DTC is characterized by an increased mortality rate in advanced stages, which contributes to the overall high mortality rate of DTC. This progression is mainly attributed to alterations in molecular driver genes, resulting in changes in phenotypes such as invasion, metastasis and dedifferentiation. Clinical management of DTC is challenging due to insufficient diagnostic and therapeutic options. The advent of‑omics technology has presented a promising avenue for the diagnosis and treatment of DTC. Identifying molecular markers that can predict the early progression of DTC to a late adverse outcome is essential for precise diagnosis and treatment. The present review aimed to enhance our understanding of DTC by integrating big data with biological systems through‑omics technology, specifically transcriptomics and proteomics, which can shed light on the molecular mechanisms underlying carcinogenesis.
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September-2023
Volume 26 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Yang S, Zhu G, He R, Fang D and Feng J: Advances in transcriptomics and proteomics in differentiated thyroid cancer: An updated perspective (Review). Oncol Lett 26: 396, 2023
APA
Yang, S., Zhu, G., He, R., Fang, D., & Feng, J. (2023). Advances in transcriptomics and proteomics in differentiated thyroid cancer: An updated perspective (Review). Oncology Letters, 26, 396. https://doi.org/10.3892/ol.2023.13982
MLA
Yang, S., Zhu, G., He, R., Fang, D., Feng, J."Advances in transcriptomics and proteomics in differentiated thyroid cancer: An updated perspective (Review)". Oncology Letters 26.3 (2023): 396.
Chicago
Yang, S., Zhu, G., He, R., Fang, D., Feng, J."Advances in transcriptomics and proteomics in differentiated thyroid cancer: An updated perspective (Review)". Oncology Letters 26, no. 3 (2023): 396. https://doi.org/10.3892/ol.2023.13982