Unusual localization and clinical presentation of primary central nervous system extranodal marginal zone B‑cell lymphoma: A case report

Fiorentino,Vincenzo; Pizzimenti,Cristina; Pierconti,Francesco; Lentini,Maria; Ieni,Antonio; Caffo,Maria; Angileri,Filippo; Tuccari,Giovanni; Fadda,Guido; Martini,Maurizio; Larocca,Luigi Maria

doi:10.3892/ol.2023.13994

Unusual localization and clinical presentation of primary central nervous system extranodal marginal zone B‑cell lymphoma: A case report

Authors:
- Vincenzo Fiorentino
- Cristina Pizzimenti
- Francesco Pierconti
- Maria Lentini
- Antonio Ieni
- Maria Caffo
- Filippo Angileri
- Giovanni Tuccari
- Guido Fadda
- Maurizio Martini
- Luigi Maria Larocca
View Affiliations

Affiliations: Department of Human Pathology in Adult and Developmental Age ‘Gaetano Barresi’, Pathology Section, University Hospital ‘G. Martino’, University of Messina, I‑98125 Messina, Italy, Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University Hospital ‘G. Martino’, University of Messina, I‑98125 Messina, Italy, Institute of Pathology, Division of Anatomic Pathology and Histology, A. Gemelli‑Scientific Institute for Research, Hospitalization and Healthcare University Hospital Foundation, I‑00168 Rome, Italy, Department of Biomedical and Dental Sciences and Morphofunctional Imaging, Section of Neurosurgery, University Hospital ‘G. Martino’, I‑98125 Messina, Italy, Department of Medicine and Surgery, Unicamillus, Saint Camillus International University of Health Sciences, International Medical University in Rome, I‑00131 Rome, Italy
Published online on: August 4, 2023 https://doi.org/10.3892/ol.2023.13994
Article Number: 408
Copyright: © Fiorentino et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

Primary central nervous system (CNS) extranodal marginal zone B‑cell lymphoma (MZBL) is a rare low‑grade non‑Hodgkin lymphoma, characterised predominantly by small B cells, plasma cells, monocytoid cells and scattered large immunoblasts. Primary CNS MZBL is a slow‑growing tumour that remains localised and is characterised by an excellent clinical prognosis. The present study describes the case of a 48‑year‑old HIV‑negative female patient with a history of head trauma 1 year prior, who presented with worsening neurological symptoms and a magnetic resonance imaging finding of a ~3‑cm extra‑axial mass within the left lateral ventricle. From histopathology and immunohistochemistry, the lesion was diagnosed as a CNS MZBL; as no other primary lesions were found, the base of the choroid plexuses of the left lateral ventricle was considered the primary site. To the best of our knowledge, the current case is the first study to report on primary CNS MZBL arising in this anatomical site and paves the way for further studies on the role of chronic inflammation (in the present case resulting from trauma) in the pathogenesis not only of primary CNS MZBL but also of lymphoma in general. Additionally, this report could serve as a starting point for studies analysing the role of meningothelial cells in the pathogenesis of primary CNS MZBL.

View Figures

View References

1	Zucca E, Arcaini L, Buske C, Johnson PW, Ponzoni M, Raderer M, Ricardi U, Salar A, Stamatopoulos K, Thieblemont C, et al: Marginal zone lymphomas: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 31:17–29. 2020. View Article : Google Scholar : PubMed/NCBI
2	Sebastián C, Vela AC, Figueroa R, Marín MÁ and Alfaro J: Primary intracranial mucosa-associated lymphoid tissue lymphoma. A report of two cases and literature review. Neuroradiol J. 27:425–430. 2014. View Article : Google Scholar : PubMed/NCBI
3	Pavlou G, Pal D, Bucur S, Chakrabarty A and van Hille PT: Intracranial non-Hodgkin's MALT lymphoma mimicking a large convexity meningioma. Acta Neurochir (Wien). 148:791–793. 2006. View Article : Google Scholar : PubMed/NCBI
4	Goda JS, Gospodarowicz M, Pintilie M, Wells W, Hodgson DC, Sun A, Crump M and Tsang RW: Long-term outcome in localized extranodal mucosa-associated lymphoid tissue lymphomas treated with radiotherapy. Cancer. 116:3815–3824. 2010. View Article : Google Scholar : PubMed/NCBI
5	Tu PH, Giannini C, Judkins AR, Schwalb JM, Burack R, O'Neill BP, Yachnis AT, Burger PC, Scheithauer BW and Perry A: Clinicopathologic and genetic profile of intracranial marginal zone lymphoma: A primary low-grade CNS lymphoma that mimics meningioma. J Clin Oncol. 23:5718–5727. 2005. View Article : Google Scholar : PubMed/NCBI
6	Lopetegui-Lia N, Delasos L, Asad SD, Kumar M and Harrison JS: Primary central nervous system marginal zone B-cell lymphoma arising from the dural meninges: A case report and review of literature. Clin Case Rep. 8:491–497. 2020. View Article : Google Scholar : PubMed/NCBI
7	Sahm F, Reuss DE and Giannini C: WHO 2016 classification: Changes and advancements in the diagnosis of miscellaneous primary CNS tumours. Neuropathol Appl Neurobiol. 44:163–171. 2018. View Article : Google Scholar : PubMed/NCBI
8	Venkataraman G, Rizzo KA, Chavez JJ, Streubel B, Raffeld M, Jaffe ES and Pittaluga S: Marginal zone lymphomas involving meningeal dura: Possible link to IgG4-related diseases. Mod Pathol. 24:355–366. 2011. View Article : Google Scholar : PubMed/NCBI
9	Ganapathi KA, Jobanputra V, Iwamoto F, Jain P, Chen J, Cascione L, Nahum O, Levy B, Xie Y, Khattar P, et al: The genetic landscape of dural marginal zone lymphomas. Oncotarget. 7:43052–43061. 2016. View Article : Google Scholar : PubMed/NCBI
10	Taipa R, Sousa L, Pinto M, Reis I, Rodrigues A, Oliveira P, Melo-Pires M and Coelho T: Neuropathology of central nervous system involvement in TTR amyloidosis. Acta Neuropathol. 145:113–126. 2023. View Article : Google Scholar : PubMed/NCBI
11	Langerak AW, Groenen PJ, Brüggemann M, Beldjord K, Bellan C, Bonello L, Boone E, Carter GI, Catherwood M, Davi F, et al: EuroClonality/BIOMED-2 guidelines for interpretation and reporting of Ig/TCR clonality testing in suspected lymphoproliferations. Leukemia. 26:2159–2171. 2012. View Article : Google Scholar : PubMed/NCBI
12	Bustoros M, Liechty B, Zagzag D, Liu C, Shepherd T, Gruber D, Raphael B and Placantonakis DG: A rare case of composite dural extranodal marginal zone lymphoma and chronic lymphocytic leukemia/small lymphocytic lymphoma. Front Neurol. 9:2672018. View Article : Google Scholar : PubMed/NCBI
13	Saggioro FP, Colli BO, Paixão-Becker AN, de Rezende GG, Santos AC and Neder L: Primary low-grade MALT lymphoma of the dura. Histopathology. 49:323–326. 2006. View Article : Google Scholar : PubMed/NCBI
14	Ren J, Cai L, Ren J, Li S and Ding L: Mucosa-associated lymphoid tissue in the central nervous system presenting as meningioma: A case report. Oncol Lett. 26:2772023. View Article : Google Scholar : PubMed/NCBI
15	Ariani R and Ballas L: Primary CNS extranodal marginal zone B-cell lymphoma: A case series of 2 patients treated with external beam radiation therapy. Case Rep Oncol. 14:725–732. 2021. View Article : Google Scholar : PubMed/NCBI
16	Ababou M, Mahtat EM, Jennane S, Elmaaroufi H, Mikdame M and Doghmi K: Splenic marginal zone lymphoma associated with hepatitis B virus infection, remission after viral treatment, and splenectomy: A case report and review of the literature. Hematol Oncol Stem Cell Ther. 14:153–155. 2021. View Article : Google Scholar : PubMed/NCBI
17	Villaume MT, Patel D, Lopez C, Patel V, Diggs P, Harmsen H, Thompson MA and Morgan D: Dural marginal zone lymphoma in a patient with a hepatitis C virus infection. World J Oncol. 11:122–125. 2020. View Article : Google Scholar : PubMed/NCBI
18	Ponzoni M, Bonetti F, Poliani PL, Vermi W, Bottelli C, Dolcetti R, Cangi MG, Ferreri AJ, Cin ED, Pasini E, et al: Central nervous system marginal zone B-cell lymphoma associated with Chlamydophila psittaci infection. Hum Pathol. 42:738–742. 2011. View Article : Google Scholar : PubMed/NCBI
19	Bende RJ, van Maldegem F and van Noesel CJ: Chronic inflammatory disease, lymphoid tissue neogenesis and extranodal marginal zone B-cell lymphomas. Haematologica. 94:1109–1123. 2009. View Article : Google Scholar : PubMed/NCBI
20	Fuller GN and Goodman JC: Practical review of neuropathology. Lippincott, Williams & Wilkins; Philadelphia: pp. 57–58. 2001, PubMed/NCBI
21	Kumar S, Kumar D, Kaldjian EP, Bauserman S, Raffeld M and Jaffe ES: Primary low-grade B-cell lymphoma of the dura: A mucosa associated lymphoid tissue-type lymphoma. Am J Surg Pathol. 21:81–87. 1997. View Article : Google Scholar : PubMed/NCBI
22	Aqil B, Rouah E and Verstovsek G: Primary CNS marginal zone lymphoma: A case report and review of the literature. Open J Pathol. 3:55–59. 2013. View Article : Google Scholar