Radiotherapy in Philadelphia chromosome‑positive acute lymphoblastic leukemia with pericardial invasion after transplantation: A case report
- Authors:
- Jing Yuan
- Yong Zhang
- Hebing Zhou
- Sen Wang
- Qiteng Liu
- Yuyan Gao
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Affiliations: Department of Radiotherapy, Beijing LuHe Hospital, Capital Medical University, Beijing 101100, P.R. China, Department of Hematology, Beijing LuHe Hospital, Capital Medical University, Beijing 101100, P.R. China, Department of Neurosurgery, Beijing LuHe Hospital, Capital Medical University, Beijing 101100, P.R. China
- Published online on: August 8, 2023 https://doi.org/10.3892/ol.2023.14001
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Article Number:
415
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Copyright: © Yuan
et al. This is an open access article distributed under the
terms of Creative
Commons Attribution License.
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Abstract
The present report describes a case of Philadelphia chromosome‑positive acute lymphoblastic leukemia (Ph+ALL) with pericardial invasion following bone marrow transplantation. The patient exhibited recurrent pericardial effusion accompanied by wheezing symptoms. Despite undergoing multiple pericardial punctures and drainage procedures, pericardial injections, and systemic treatment, the patient continued to experience recurrent pericardial effusion. Ultimately, the patient underwent whole‑heart radiotherapy, resulting in complete resolution of the pericardial effusion. After a follow‑up period of 10 months, the pericardial effusion remained well‑controlled, and there were no significant impairments in cardiac function. In conclusion, radiotherapy may be considered as a viable treatment option for refractory leukemia cases presenting with pericardial effusion.
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