Open Access

Advance in vasculogenic mimicry in ovarian cancer (Review)

  • Authors:
    • Xinyuan Tian
    • Qin Si
    • Menghe Liu
    • Jianping Shi
    • Rongwei Zhao
    • Yang Xiong
    • Lei Yu
    • Hongwei Cui
    • Haibin Guan
  • View Affiliations

  • Published online on: September 5, 2023     https://doi.org/10.3892/ol.2023.14043
  • Article Number: 456
  • Copyright: © Tian et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Ovarian cancer (OC) is a common and highly prevalent malignant tumor in women, associated with a high mortality rate, easy recurrence and easy metastasis, which is predominantly at an advanced stage when detected in patients. This renders the cancer more difficult to treat, and consequently it is also associated with a low survival rate, being the malignancy with the highest mortality rate among the various gynecological tumors. As an important factor affecting the development and metastasis of OC, understanding the underlying mechanism(s) through which it is formed and developed is crucial in terms of its treatment. At present, the therapeutic methods of angiogenic mimicry for OC remain in the preliminary stages of exploration and have not been applied in actual clinical practice. In the present review, various signaling pathways and factors affecting angiogenic mimicry in OC were described, and the chemical synthetic drugs, natural compound extracts, small‑molecule protein antibodies and their associated targets, and so on, that target angiogenic mimicry in the treatment of OC, were discussed. The purpose of this review was to provide new research ideas and potential theoretical support for the discovery of novel therapeutic targets for OC that may be applied in the clinic, with the aim of effectively reducing its metastasis and recurrence rates.
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October-2023
Volume 26 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Tian X, Si Q, Liu M, Shi J, Zhao R, Xiong Y, Yu L, Cui H and Guan H: Advance in vasculogenic mimicry in ovarian cancer (Review). Oncol Lett 26: 456, 2023.
APA
Tian, X., Si, Q., Liu, M., Shi, J., Zhao, R., Xiong, Y. ... Guan, H. (2023). Advance in vasculogenic mimicry in ovarian cancer (Review). Oncology Letters, 26, 456. https://doi.org/10.3892/ol.2023.14043
MLA
Tian, X., Si, Q., Liu, M., Shi, J., Zhao, R., Xiong, Y., Yu, L., Cui, H., Guan, H."Advance in vasculogenic mimicry in ovarian cancer (Review)". Oncology Letters 26.4 (2023): 456.
Chicago
Tian, X., Si, Q., Liu, M., Shi, J., Zhao, R., Xiong, Y., Yu, L., Cui, H., Guan, H."Advance in vasculogenic mimicry in ovarian cancer (Review)". Oncology Letters 26, no. 4 (2023): 456. https://doi.org/10.3892/ol.2023.14043