Open Access

Expression pattern, prognostic value and potential microRNA silencing of FZD8 in breast cancer

  • Authors:
    • Maryam H. Al-Zahrani
    • Mourad Assidi
    • Peter Natesan Pushparaj
    • Jaudah Al‑Maghrabi
    • Ali Zari
    • Atlal Abusanad
    • Abdelbaset Buhmeida
    • Muhammad Abu‑Elmagd
  • View Affiliations

  • Published online on: September 21, 2023     https://doi.org/10.3892/ol.2023.14065
  • Article Number: 477
  • Copyright: © Al-Zahrani et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Breast cancer (BC) is one of the most widespread types of cancer affecting females, and therefore, early diagnosis is critical. BC is a complex heterogeneous disease affected by several key pathways. Among these, WNT proteins and their frizzled receptors (FZD) have been demonstrated to be crucial in regulating a number of cellular and molecular events in BC tumorigenesis. The role of the WNT receptor, FZD8, in BC has received minimal attention; for that reason, the present study examined the prognostic value of its protein expression pattern in a BC cohort. FZD8 cytoplasmic expression pattern analysis revealed that ~38% of the primary samples presented with a high expression profile, whereas ~63% of the samples had a low expression profile. Overall, ~46% of the malignant tissues in the lymph node‑positive samples exhibited an increased FZD8 cytoplasmic expression, whereas 54% exhibited low expression levels. An increased expression of FZD8 was associated with several clinicopathological characteristics of the patients, including a low survival rate, tumor vascular invasion, tumor size and grade, and molecular subtypes. Affymetrix microarray triple‑negative BC datasets were analyzed and compared with healthy breast tissues in order to predict the potential interfering microRNAs (miRNAs) in the WNT/FZD8 signaling pathway. A total of 29 miRNAs with the potential to interact with the WNT/FZD8 signaling pathway were identified, eight of which exhibited a significant prediction score. The target genes for each predicted miRNA were identified. On the whole, the findings of the present study suggest that FZD8 is a potential prognostic marker for BC, shedding some light onto the silencing mechanisms involved in the complex BC signaling.
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November-2023
Volume 26 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Al-Zahrani MH, Assidi M, Pushparaj PN, Al‑Maghrabi J, Zari A, Abusanad A, Buhmeida A and Abu‑Elmagd M: Expression pattern, prognostic value and potential microRNA silencing of FZD8 in breast cancer. Oncol Lett 26: 477, 2023
APA
Al-Zahrani, M.H., Assidi, M., Pushparaj, P.N., Al‑Maghrabi, J., Zari, A., Abusanad, A. ... Abu‑Elmagd, M. (2023). Expression pattern, prognostic value and potential microRNA silencing of FZD8 in breast cancer. Oncology Letters, 26, 477. https://doi.org/10.3892/ol.2023.14065
MLA
Al-Zahrani, M. H., Assidi, M., Pushparaj, P. N., Al‑Maghrabi, J., Zari, A., Abusanad, A., Buhmeida, A., Abu‑Elmagd, M."Expression pattern, prognostic value and potential microRNA silencing of FZD8 in breast cancer". Oncology Letters 26.5 (2023): 477.
Chicago
Al-Zahrani, M. H., Assidi, M., Pushparaj, P. N., Al‑Maghrabi, J., Zari, A., Abusanad, A., Buhmeida, A., Abu‑Elmagd, M."Expression pattern, prognostic value and potential microRNA silencing of FZD8 in breast cancer". Oncology Letters 26, no. 5 (2023): 477. https://doi.org/10.3892/ol.2023.14065