Mechanistic insights into UHRF1‑mediated DNA methylation by structure‑based functional clarification of UHRF1 domains (Review)

  • Authors:
    • Yiying Song
    • Haiting Liu
    • Qingqing Xian
    • Chengzhi Gui
    • Mingjie Xu
    • Yunying Zhou
  • View Affiliations

  • Published online on: November 2, 2023     https://doi.org/10.3892/ol.2023.14129
  • Article Number: 542
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Abstract

Epigenetic modification is crucial for transmitting genetic information, while abnormalities in DNA methylation modification are primarily associated with cancer and neurological diseases. As a multifunctional epigenetic modifier, ubiquitin like with PHD and ring finger domains 1 (UHRF1) mainly affects cell energy metabolism and cell cycle control. It also inhibits the transcription of tumor suppressor genes through DNA and/or histone methylation modifications, promoting the occurrence and development of cancer. Therefore, comprehensively understanding the molecular mechanism of the epigenetic modification of UHRF1 in tumors will help identify targets for inhibiting the expression and function of UHRF1. Notably, each domain of UHRF1 functions as a whole and differently. Thus, the abnormality of any domain can lead to a change in phenotype or disease. However, the specific regulatory mechanism and proteins of each domain have not been fully elucidated. The present review aimed to contribute to the study of the regulatory mechanism of UHRF1 to a greater extent in different cancers and provide ideas for drug research by clarifying the function of UHRF1 domains.
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December-2023
Volume 26 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Song Y, Liu H, Xian Q, Gui C, Xu M and Zhou Y: Mechanistic insights into UHRF1‑mediated DNA methylation by structure‑based functional clarification of UHRF1 domains (Review). Oncol Lett 26: 542, 2023.
APA
Song, Y., Liu, H., Xian, Q., Gui, C., Xu, M., & Zhou, Y. (2023). Mechanistic insights into UHRF1‑mediated DNA methylation by structure‑based functional clarification of UHRF1 domains (Review). Oncology Letters, 26, 542. https://doi.org/10.3892/ol.2023.14129
MLA
Song, Y., Liu, H., Xian, Q., Gui, C., Xu, M., Zhou, Y."Mechanistic insights into UHRF1‑mediated DNA methylation by structure‑based functional clarification of UHRF1 domains (Review)". Oncology Letters 26.6 (2023): 542.
Chicago
Song, Y., Liu, H., Xian, Q., Gui, C., Xu, M., Zhou, Y."Mechanistic insights into UHRF1‑mediated DNA methylation by structure‑based functional clarification of UHRF1 domains (Review)". Oncology Letters 26, no. 6 (2023): 542. https://doi.org/10.3892/ol.2023.14129