Large renal lymphoma in a patient with horseshoe kidney: A case report

Iovino,Francesco; Mongardini,Federico Maria; Balestrucci,Giovanni; Regginelli,Alfonso; Ronchi,Andrea; Ferrara,Maria Giovanna; Parisi,Simona; Gambardella,Claudio; Lucido,Francesco Saverio; Tolone,Salvatore; Ruggiero,Roberto; Docimo,Ludovico

doi:10.3892/ol.2023.14180

Large renal lymphoma in a patient with horseshoe kidney: A case report

Authors:
- Francesco Iovino
- Federico Maria Mongardini
- Giovanni Balestrucci
- Alfonso Regginelli
- Andrea Ronchi
- Maria Giovanna Ferrara
- Simona Parisi
- Claudio Gambardella
- Francesco Saverio Lucido
- Salvatore Tolone
- Roberto Ruggiero
- Ludovico Docimo
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Affiliations: Department of Translational Medical Sciences, School of Medicine, University of Campania Luigi Vanvitelli, I‑80131 Naples, Italy, Department of Precision Medicine, School of Medicine, University of Campania Luigi Vanvitelli, I‑80131 Naples, Italy, Department of Mental and Physical Health and Preventive Medicine, School of Medicine, University of Campania Luigi Vanvitelli, I‑80131 Naples, Italy, Department of Advanced Medical and Surgical Sciences, School of Medicine, University of Campania Luigi Vanvitelli, I‑80131 Naples, Italy
Published online on: December 7, 2023 https://doi.org/10.3892/ol.2023.14180
Article Number: 46
Copyright: © Iovino et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Horseshoe kidney (HSK) is the most common renal fusion anomaly. It frequently consists of kidney fusion in the lower pole across the midline and occurs during embryogenesis. The incidence of malignancies in HSKs can be 3‑4 times higher than that in normal kidneys. A 69‑year‑old man with a voluminous right kidney neoplasm in HSK and a single omolateral axillary lymphadenopathy underwent complete excision of right axillary lymphadenopathy and ultrasound‑guided percutaneous biopsy of the right kidney expansive lesion. The diagnosis of non‑Hodgkin's B cell lymphoma both in HSK and right axilla was made. We report this case to raise awareness among physicians regarding the importance of a correct clinical evaluation and diagnostic workup so as to avoid surgery, which is not easy and without complications, in patients with this kidney anomaly. Primary renal lymphoma should also be included among possible neoplasms of HSK. Renal biopsy should always be recommended in cases where atypical findings are obtained from imaging techniques and when its outcome can impact clinical decision‑making. In the present case, biopsy was performed, and thus, nephrectomy was avoided and specific medical therapy was quickly started.

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