Open Access

Role of prognostic gene DKK1 in oral squamous cell carcinoma

  • Authors:
    • Yujiao Liu
    • Congcong Wei
    • Song Wang
    • Shuxin Ding
    • Yanan Li
    • Yongguo Li
    • Dongping Zhang
    • Guoxiong Zhu
    • Zhen Meng
  • View Affiliations

  • Published online on: December 12, 2023     https://doi.org/10.3892/ol.2023.14184
  • Article Number: 52
  • Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Oral squamous cell carcinoma (OSCC) is one of the most common squamous cell carcinomas of the head and neck. The morbidity and mortality rates of OSCC have increased in recent years. However, the pathogenesis of this disease remains unknown. The present study aimed to identify predictive biomarkers and therapeutic targets for OSCC. Bioinformatics screening of differentially expressed genes in OSCC was performed based on data from The Cancer Genome Atlas and Gene Expression Omnibus databases. Dickkopf Wnt signaling pathway inhibitor 1 (DKK1) was identified to be associated with survival, tumor immunity and DNA repair in OSCC. Furthermore, the effects of DKK1 were evaluated by the knockdown of DKK1 in two OSCC cell lines. The proliferation, clonogenicity, migration and invasion of the cells were assessed in vitro using Cell Counting Kit‑8, colony formation, wound healing and Transwell assays, respectively, and were found to be inhibited by DKK1 knockdown. The present study suggests that DKK1 may be used in the prognosis of patients with OSCC and that targeting DKK1 is a potential strategy for OSCC therapy.
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February-2024
Volume 27 Issue 2

Print ISSN: 1792-1074
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Copy and paste a formatted citation
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Spandidos Publications style
Liu Y, Wei C, Wang S, Ding S, Li Y, Li Y, Zhang D, Zhu G and Meng Z: Role of prognostic gene DKK1 in oral squamous cell carcinoma. Oncol Lett 27: 52, 2024.
APA
Liu, Y., Wei, C., Wang, S., Ding, S., Li, Y., Li, Y. ... Meng, Z. (2024). Role of prognostic gene DKK1 in oral squamous cell carcinoma. Oncology Letters, 27, 52. https://doi.org/10.3892/ol.2023.14184
MLA
Liu, Y., Wei, C., Wang, S., Ding, S., Li, Y., Li, Y., Zhang, D., Zhu, G., Meng, Z."Role of prognostic gene DKK1 in oral squamous cell carcinoma". Oncology Letters 27.2 (2024): 52.
Chicago
Liu, Y., Wei, C., Wang, S., Ding, S., Li, Y., Li, Y., Zhang, D., Zhu, G., Meng, Z."Role of prognostic gene DKK1 in oral squamous cell carcinoma". Oncology Letters 27, no. 2 (2024): 52. https://doi.org/10.3892/ol.2023.14184