Open Access

Prognostic value of a modified‑immune scoring system in patients with pathological T4 colorectal cancer

  • Authors:
    • Gendensuren Dorjkhorloo
    • Bilguun Erkhem‑Ochir
    • Takuya Shiraishi
    • Makoto Sohda
    • Haruka Okami
    • Arisa Yamaguchi
    • Ikuma Shioi
    • Chika Komine
    • Nobuhiro Nakazawa
    • Naoya Ozawa
    • Yuta Shibasaki
    • Takuhisa Okada
    • Katsuya Osone
    • Akihiko Sano
    • Makoto Sakai
    • Hiroomi Ogawa
    • Takehiko Yokobori
    • Ken Shirabe
    • Hiroshi Saeki
  • View Affiliations

  • Published online on: January 17, 2024     https://doi.org/10.3892/ol.2024.14237
  • Article Number: 104
  • Copyright: © Dorjkhorloo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Tumor‑infiltrating immune cells, such as lymphocytes and macrophages, have been associated with tumor aggressiveness, prognosis and treatment response in colorectal cancer (CRC). An immune scoring system, Immunoscore (IS), based on tumor‑infiltrating T cells in stage I‑III CRC, was used to predict prognosis. An alternative immune scoring signature of immune activation (SIA) reflects the balance between anti‑ and pro‑tumoral immune components. The present study aimed to evaluate the prognostic value of modified IS (mIS) and modified SIA (mSIA) in locally advanced pathological T4 (pT4) CRC, including stage IV CRC. Immunohistochemical staining for immune cell markers, such as CD3 (pan‑T cell marker), CD8 (anti‑tumoral cytotoxic T cell marker) and CD163 (tumor‑supportive macrophage marker), in specimens from patients with radically resected pT4 CRC at stages II‑IV was performed. mIS levels in the T4 CRC cohort were not associated with prognosis. However, low mSIA levels were associated with low survival. Furthermore, low mSIA was an independent predictor of recurrence in patients with radically resected pT4 CRC. In patients with CRC who did not receive postoperative adjuvant chemotherapy, low mSIA was a major poor prognostic factor; however, this was not observed in patients receiving adjuvant chemotherapy. Evaluation of the tumor‑infiltrating immune cell population could serve as a valuable marker of recurrence and poor prognosis in patients with locally advanced CRC. mSIA assessment after radical CRC resection may be promising for identifying high‑risk patients with pT4 CRC who require aggressive adjuvant chemotherapy.
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March-2024
Volume 27 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Dorjkhorloo G, Erkhem‑Ochir B, Shiraishi T, Sohda M, Okami H, Yamaguchi A, Shioi I, Komine C, Nakazawa N, Ozawa N, Ozawa N, et al: Prognostic value of a modified‑immune scoring system in patients with pathological T4 colorectal cancer. Oncol Lett 27: 104, 2024.
APA
Dorjkhorloo, G., Erkhem‑Ochir, B., Shiraishi, T., Sohda, M., Okami, H., Yamaguchi, A. ... Saeki, H. (2024). Prognostic value of a modified‑immune scoring system in patients with pathological T4 colorectal cancer. Oncology Letters, 27, 104. https://doi.org/10.3892/ol.2024.14237
MLA
Dorjkhorloo, G., Erkhem‑Ochir, B., Shiraishi, T., Sohda, M., Okami, H., Yamaguchi, A., Shioi, I., Komine, C., Nakazawa, N., Ozawa, N., Shibasaki, Y., Okada, T., Osone, K., Sano, A., Sakai, M., Ogawa, H., Yokobori, T., Shirabe, K., Saeki, H."Prognostic value of a modified‑immune scoring system in patients with pathological T4 colorectal cancer". Oncology Letters 27.3 (2024): 104.
Chicago
Dorjkhorloo, G., Erkhem‑Ochir, B., Shiraishi, T., Sohda, M., Okami, H., Yamaguchi, A., Shioi, I., Komine, C., Nakazawa, N., Ozawa, N., Shibasaki, Y., Okada, T., Osone, K., Sano, A., Sakai, M., Ogawa, H., Yokobori, T., Shirabe, K., Saeki, H."Prognostic value of a modified‑immune scoring system in patients with pathological T4 colorectal cancer". Oncology Letters 27, no. 3 (2024): 104. https://doi.org/10.3892/ol.2024.14237