Stage IV and recurrent colorectal cancer cured following multimodal therapy: A case series

Kurata,Yoshihiro; Imai,Yasuo; Hirata,Atsushi; Ichinose,Masanori

doi:10.3892/ol.2024.14250

Stage IV and recurrent colorectal cancer cured following multimodal therapy: A case series

Authors:
- Yoshihiro Kurata
- Yasuo Imai
- Atsushi Hirata
- Masanori Ichinose
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Affiliations: Department of Digestive Surgery, International University of Health and Welfare, Shioya Hospital, Yaita, Tochigi 329‑2145, Japan, Department of Diagnostic Pathology, Ota Memorial Hospital, SUBARU Health Insurance Society, Ota, Gunma 373‑8585, Japan
Published online on: January 23, 2024 https://doi.org/10.3892/ol.2024.14250
Article Number: 117

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Abstract

The treatment strategies for colorectal cancer (CRC) with distant metastasis or metastatic recurrence after resection of the primary tumor are controversial. In the present study, four cases of patients with advanced CRC with distant metastasis who achieved disease‑free survival (DFS) for >5 years and were deemed potentially cured were reported. Case 1 was that of a 53‑year‑old male patient with rectal cancer and liver metastases (pT3N2bM1, pStage IV), and case 2 was that of a 58‑year‑old female patient with descending colon cancer (pT3N1M1, pStage IV) who had lung metastases at surgery and postoperatively. Both patients achieved DFS for >5 years after simultaneous or staged partial hepatectomy or pneumonectomy followed by chemotherapy. Case 3 was that of a 75‑year‑old male patient with transverse colon cancer (pT3N1M0, pStage IIIB) and case 4 was that of a 73‑year‑old male patient with sigmoid colon cancer (pT3N0M0, pStage IIA). These cases developed liver metastases after resection of the primary tumour and were subsequently treated with chemotherapy before or after partial hepatectomy. DFS for >5 years was achieved. All four patients were considered cured. The data revealed that even patients with CRC and distant metastases can potentially be cured following multidisciplinary treatment. In the present case report, the factors that enabled these patients to be considered cured were discussed and the aim was to improve the treatment strategy to cure CRC with distant metastasis or recurrence.

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