Prognostic value of tumor‑associated CD177<sup>+</sup> neutrophils in lung adenocarcinoma

Zhou,Jinhua; Xu,Qingxia; Liu,Huan; Miao,Jianlong; Bian,Cuixia; Wei,Yutao; Wang,Wei; Jiang,Shulong

doi:10.3892/ol.2024.14322

Prognostic value of tumor‑associated CD177⁺ neutrophils in lung adenocarcinoma

Authors:
- Jinhua Zhou
- Qingxia Xu
- Huan Liu
- Jianlong Miao
- Cuixia Bian
- Yutao Wei
- Wei Wang
- Shulong Jiang
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Affiliations: Department of Respiratory Medicine, The Second Hospital of Shandong University, Jinan, Shandong 250033, P.R. China, Department of Pathology, Jining First People's Hospital, Jining, Shandong 272000, P.R. China, Department of Emergency Internal Medicine, Jining First People's Hospital, Jining, Shandong 272000, P.R. China, Department of Respiratory Medicine, Jining First People's Hospital, Jining, Shandong 272000, P.R. China, Department of Thoracic Surgery, Jining First People's Hospital, Jining, Shandong 272000, P.R. China, Department of Respiratory Medicine, The Second Hospital of Shandong University, Jinan, Shandong 250033, P.R. China, Clinical Medical Laboratory Center, Jining First People's Hospital, Jining, Shandong 272000, P.R. China
Published online on: March 1, 2024 https://doi.org/10.3892/ol.2024.14322
Article Number: 189
Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the present study was to detect CD177⁺ neutrophils in tumor tissues and analyze their association with the clinical characteristics and prognosis of patients with lung adenocarcinoma (LUAD). Immunohistochemistry was used to detect CD177⁺ neutrophils in tumors and adjacent tissues of 16 patients with LUAD who underwent curative surgical resection. A total of 120 patients with LUAD were recruited, and their clinical data were collected; survival follow‑up was performed. CD177⁺ neutrophils in tumor tissues were detected via immunohistochemistry, and the association between CD177⁺ neutrophils and clinical characteristics was analyzed. The density of CD177⁺ neutrophils in tumor tissues and adjacent tissues of patients with LUAD was analyzed using t‑test, and the association between CD177⁺ neutrophils and clinical characteristics was analyzed through the Chi‑square test. Survival was calculated using the Kaplan‑Meier survival rate curve. Finally, the association between these indicators and the survival of LUAD patients was evaluated using Cox regression analysis. CD177⁺ neutrophil infiltration was significantly higher in LUAD tumor tissues, and the high density of CD177⁺ neutrophils was associated with the clinical characteristics of TNM stage, tumor differentiation and poor progression‑free and overall survival in LUAD. In conclusion, tumor‑associated CD177⁺ neutrophils associated with malignant progression and poor prognosis may be independent and unfavorable prognostic biomarkers for LUAD.

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