Effect of valproic acid on histone deacetylase expression in oral cancer (Review)

  • Authors:
    • Ahmed S.K. Al‑Khafaji
    • Lydia M. Wang
    • Haidar H. Alabdei
    • Triantafillos Liloglou
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  • Published online on: March 7, 2024     https://doi.org/10.3892/ol.2024.14330
  • Article Number: 197
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Abstract

Oral squamous cell carcinoma (OSCC) is a frequent human malignancy that demonstrates a range of genetic and epigenetic alterations. Histone deacetylases (HDACs) are key epigenetic regulators of cell‑cycle progression, differentiation and apoptosis and their dysregulation is implicated in cancer development. HDACs are promising targets for anticancer therapy through the utilisation of HDAC inhibitors (HDACis). OSCC cells have been shown to have low levels of histone acetylation, suggesting that HDACis may produce beneficial effects in patients with OSCC. Valproic acid (VPA) is a class I and IIa HDACi and, therefore, may be useful in anticancer therapy. VPA has been reported as a chemo‑preventive epigenetic agent in individuals with high‑risk oral dysplasia (OD) and thus associated with a reduced risk of HNSCC. It is hypothesised that HDAC inhibition by VPA triggers a change in the expression levels of different HDAC family gene‑members. The present review summarises the current literature on HDAC expression changes in response to VPA in oral cancer patients and in vitro studies in an effort to better understand the potential epigenetic impact of VPA treatment. The present review outlined the need for exploring supportive evidence of the chemo‑preventive role played by VPA‑based epigenetic modification in treating oral pre‑cancerous lesions and, thus, providing a novel tolerable chemotherapeutic strategy for patients with oral cancer.
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May-2024
Volume 27 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Al‑Khafaji AS, Wang LM, Alabdei HH and Liloglou T: Effect of valproic acid on histone deacetylase expression in oral cancer (Review). Oncol Lett 27: 197, 2024.
APA
Al‑Khafaji, A.S., Wang, L.M., Alabdei, H.H., & Liloglou, T. (2024). Effect of valproic acid on histone deacetylase expression in oral cancer (Review). Oncology Letters, 27, 197. https://doi.org/10.3892/ol.2024.14330
MLA
Al‑Khafaji, A. S., Wang, L. M., Alabdei, H. H., Liloglou, T."Effect of valproic acid on histone deacetylase expression in oral cancer (Review)". Oncology Letters 27.5 (2024): 197.
Chicago
Al‑Khafaji, A. S., Wang, L. M., Alabdei, H. H., Liloglou, T."Effect of valproic acid on histone deacetylase expression in oral cancer (Review)". Oncology Letters 27, no. 5 (2024): 197. https://doi.org/10.3892/ol.2024.14330