Open Access

Effectiveness and safety of neoadjuvant apatinib in combination with capecitabine and oxaliplatin for the therapy of locally advanced colorectal cancer: A retrospective study

  • Authors:
    • Tao Zhang
    • Xinyu Peng
    • Gang Li
    • Liqi Yan
    • Aimin Zhang
    • Xiongjie Jia
  • View Affiliations

  • Published online on: March 11, 2024     https://doi.org/10.3892/ol.2024.14335
  • Article Number: 201
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The goal of the present study was to appraise the efficacy and safety of neoadjuvant apatinib in combination with capecitabine and oxaliplatin (XELOX) in patients with locally advanced colorectal cancer (CRC), as relevant data on its usage in this setting are lacking. A retrospective analysis was implemented on 100 patients with locally advanced CRC who received either neoadjuvant apatinib in combination with XELOX (N=50) or neoadjuvant XELOX alone (N=50). Radiological response and pathological complete response rates were evaluated. Furthermore, the researchers obtained data pertaining to disease‑free survival (DFS), overall survival, as well as adverse events. The consequences of the present study indicated that the neoadjuvant apatinib in combination with XELOX treatment approach yielded higher rates of radiological objective response (86.0 vs. 68.0%, P=0.032) and major pathological response (46.0 vs. 22.0%, P=0.011) compared with XELOX alone. These findings were further confirmed through multivariate logistic regression analyses (P=0.037 and P=0.008, respectively). Interestingly, the neoadjuvant apatinib in combination with XELOX treatment approach significantly prolonged DFS when compared with XELOX alone (P=0.033). In summary, the administration of neoadjuvant apatinib in combination with XELOX demonstrates superiority over the use of XELOX alone in terms of achieving a more favorable pathological response and a longer duration of DFS in patients diagnosed with locally advanced CRC.
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May-2024
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Spandidos Publications style
Zhang T, Peng X, Li G, Yan L, Zhang A and Jia X: Effectiveness and safety of neoadjuvant apatinib in combination with capecitabine and oxaliplatin for the therapy of locally advanced colorectal cancer: A retrospective study. Oncol Lett 27: 201, 2024.
APA
Zhang, T., Peng, X., Li, G., Yan, L., Zhang, A., & Jia, X. (2024). Effectiveness and safety of neoadjuvant apatinib in combination with capecitabine and oxaliplatin for the therapy of locally advanced colorectal cancer: A retrospective study. Oncology Letters, 27, 201. https://doi.org/10.3892/ol.2024.14335
MLA
Zhang, T., Peng, X., Li, G., Yan, L., Zhang, A., Jia, X."Effectiveness and safety of neoadjuvant apatinib in combination with capecitabine and oxaliplatin for the therapy of locally advanced colorectal cancer: A retrospective study". Oncology Letters 27.5 (2024): 201.
Chicago
Zhang, T., Peng, X., Li, G., Yan, L., Zhang, A., Jia, X."Effectiveness and safety of neoadjuvant apatinib in combination with capecitabine and oxaliplatin for the therapy of locally advanced colorectal cancer: A retrospective study". Oncology Letters 27, no. 5 (2024): 201. https://doi.org/10.3892/ol.2024.14335