Metastasis to the bladder from primary breast cancer: A case report and literature review

Zhou,Hanli; Liu,Danna; Chen,Lu; Zhang,Yujie; Zhao,Xiaoli; Ge,Yongchao; Liu,Mengmeng; Kong,Tiandong

doi:10.3892/ol.2024.14382

Metastasis to the bladder from primary breast cancer: A case report and literature review

Authors:
- Hanli Zhou
- Danna Liu
- Lu Chen
- Yujie Zhang
- Xiaoli Zhao
- Yongchao Ge
- Mengmeng Liu
- Tiandong Kong
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Affiliations: Department of Oncology, Cancer Hospital of Henan University, The Third People's Hospital of Zhengzhou, Zhengzhou, Henan 450000, P.R. China, Department of Pharmacy, Cancer Hospital of Henan University, The Third People's Hospital of Zhengzhou, Zhengzhou, Henan 450000, P.R. China, Department of Urology, Cancer Hospital of Henan University, The Third People's Hospital of Zhengzhou, Zhengzhou, Henan 450000, P.R. China, Department of Pathology, Cancer Hospital of Henan University, The Third People's Hospital of Zhengzhou, Zhengzhou, Henan 450000, P.R. China
Published online on: April 5, 2024 https://doi.org/10.3892/ol.2024.14382
Article Number: 249
Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Breast cancer is the most prevalent malignant tumor affecting women and represents the leading cause of female cancer‑related mortality worldwide. Although distant organ metastasis accounts for the majority of breast cancer‑related deaths, reports on bladder metastasis are limited in the existing literature. The present study describes the case of a patient with bladder metastasis originating from breast cancer. In addition, the present study also provides a review of 54 cases of similar disease that have been documented in the currently available literature. The literature review aims to elucidate the clinicopathological characteristics and therapeutic approaches for such conditions. The median time from breast cancer diagnosis to bladder metastasis was found to be 5.6 years (range, 0‑28 years). The origin of the bladder metastases was predominantly invasive ductal carcinoma (IDC) accounting for 52.3% of cases, followed by invasive lobular carcinoma, accounting for 40.9% of cases. The pathology in the primary tumor was the same as the pathology of the bladder metastases in all cases. There was an 88.9% concordance rate for estrogen receptor status, while the progesterone receptor status was 83.3% and the human epidermal growth factor receptor 2 expression status was 100%. The primary initial symptoms included urinary system manifestations, such as increased frequency, urgency, dysuria, urinary incontinence, nocturia and gross hematuria. For the cystoscopic examination, the predominant findings were bladder wall thickening or masses, along with ureteral orifice masses. Overall, the present study demonstrated that the occurrence of bladder metastasis often follows the metastasis of other organs, with IDC being the most prevalent subtype. The pathological characteristics between the primary tumor and bladder metastasis exhibit a high degree of concordance.

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1	Katsura C, Ogunmwonyi I, Kankam HK and Saha S: Breast cancer: Presentation, investigation and management. Br J Hosp Med (Lond). 83:1–7. 2022. View Article : Google Scholar : PubMed/NCBI
2	Arnold M, Morgan E, Rumgay H, Mafra A, Singh D, Laversanne M, Vignat J, Gralow JR, Cardoso F, Siesling S and Soerjomataram I: Current and future burden of breast cancer: Global statistics for 2020 and 2040. Breast. 66:15–23. 2022. View Article : Google Scholar : PubMed/NCBI
3	Peng Z, Wei J, Lu X, Zheng H, Zhong X, Gao W, Chen Y and Jing J: Treatment and survival patterns of Chinese patients diagnosed with breast cancer between 2005 and 2009 in Southwest China: An observational, population-based cohort study. Medicine (Baltimore). 95:e38652016. View Article : Google Scholar : PubMed/NCBI
4	Lou Z, Fei X, Christakos G, Yan J and Wu J: Improving spatiotemporal breast cancer assessment and prediction in Hangzhou City, China. Sci Rep. 7:31882017. View Article : Google Scholar : PubMed/NCBI
5	Trayes KP and Cokenakes S: Breast cancer treatment. Am Fam Physician. 104:171–178. 2021.PubMed/NCBI
6	Malinaric R, Balzarini F, Granelli G, Ferrari A, Trani G, Ambrosini F, Mantica G, Panarello D, De Rose AF and Terrone C: From women to women-hematuria during therapy for metastatic breast cancer, what to suspect and when to be alarmed; Bladder metastasis from breast cancer-our experience and a systematic literature review. Front Oncol. 12:9769472022. View Article : Google Scholar : PubMed/NCBI
7	Wei S and Siegal GP: Metastatic organotropism: An intrinsic property of breast cancer molecular subtypes. Adv Anat Pathol. 24:78–81. 2017. View Article : Google Scholar : PubMed/NCBI
8	Sanguedolce F, Landriscina M, Ambrosi A, Tartaglia N, Cianci P, Di Millo M, Carrieri G, Bufo P and Cormio L: Bladder metastases from breast cancer: Managing the unexpected. a systematic review. Urol Int. 101:125–131. 2018. View Article : Google Scholar : PubMed/NCBI
9	Ashley S, Choudhury A, Hoskin P, Song Y and Maitre P: Radiotherapy in metastatic bladder cancer. World J Urol. 42:472024. View Article : Google Scholar : PubMed/NCBI
10	Wu Q, Li J, Zhu S, Wu J, Chen C, Liu Q, Wei W, Zhang Y and Sun S: Breast cancer subtypes predict the preferential site of distant metastases: A SEER based study. Oncotarget. 8:27990–27996. 2017. View Article : Google Scholar : PubMed/NCBI
11	Bates AW and Baithun SI: Secondary neoplasms of the bladder are histological mimics of nontransitional cell primary tumours: Clinicopathological and histological features of 282 cases. Histopathology. 36:32–40. 2000. View Article : Google Scholar : PubMed/NCBI
12	Khan NAJ, Abdallah M and Tirona MT: Hormone Receptor Positive/HER2 negative breast cancer with isolated bladder metastasis: A rare case. J Investig Med High Impact Case Rep. 9:232470962110221862021.PubMed/NCBI
13	Zhu H and Doğan BE: American Joint Committee on Cancer's Staging System for Breast Cancer, Eighth Edition: Summary for Clinicians. Eur J Breast Health. 17:234–238. 2021. View Article : Google Scholar : PubMed/NCBI
14	Zhai ZX SJJ and Wang ZP: Invasive lobular carcinoma of breast with metastatic tumor of bladder and bone: A case report and literature review. J Contemp Urol Reprod Oncol. 5:308–309. 2013.
15	Nieder C and Pawinski A: A case of recurrent breast cancer with solitary metastasis to the urinary bladder. Case Rep Oncol Med. 2014:9315462014.PubMed/NCBI
16	Wang G, Zhou C, Conklin C, Hayes MM, Villamil CF, Ostry A and Jones EC: Metastatic breast carcinoma to the urinary bladder-a report of 11 cases including a tumor to tumor metastasis. Virchows Arch. 474:333–339. 2019. View Article : Google Scholar : PubMed/NCBI
17	Shah KG, Modi PR and Rizvi J: Breast carcinoma metastasizing to the urinary bladder and retroperitoneum presenting as acute renal failure. Indian J Urol. 27:135–136. 2011. View Article : Google Scholar : PubMed/NCBI
18	Gatti G, Zurrida S, Gilardi D, Bassani G, dos Santos GR and Luini A: Urinary bladder metastases from breast carcinoma: Review of the literature starting from a clinical case. Tumori. 91:283–286. 2005. View Article : Google Scholar : PubMed/NCBI
19	Ghaida RA, Ayoub H, Nasr R, Issa G and Bulbul M: Bladder metastasis from primary breast cancer: A case report and literature review. Cent European J Urol. 66:177–184. 2013.PubMed/NCBI
20	Zagha RM and Hamawy KJ: Solitary breast cancer metastasis to the bladder: An unusual occurrence. Urol Oncol. 25:236–239. 2007. View Article : Google Scholar : PubMed/NCBI
21	Elia G, Stewart S, Makhuli ZN, Krenzer BE, Mathur S, Simon HM and Mehdi S: Metastatic breast cancer diagnosed during a work-up for urinary incontinence: A case report. Int Urogynecol J Pelvic Floor Dysfunct. 10:39–42. 1999. View Article : Google Scholar : PubMed/NCBI
22	Poulakis V, Witzsch U, de Vries R and Becht E: Metastatic breast carcinoma to the bladder: 5-year followup. J Urol. 165:9052001. View Article : Google Scholar : PubMed/NCBI
23	Kleinmann N, Mor Y, Laufer M, Duvdevani M, Fridman E and Ramon J: A solitary metastasis of breast cancer to the urinary bladder. Breast J. 11:4972005. View Article : Google Scholar : PubMed/NCBI
24	Lin WC and Chen JH: Urinary bladder metastasis from breast cancer with heterogeneic expression of estrogen and progesterone receptors. J Clin Oncol. 25:4308–4310. 2007. View Article : Google Scholar : PubMed/NCBI
25	Xiao GQ, Chow J and Unger PD: Metastatic tumors to the urinary bladder: Clinicopathologic study of 11 cases. Int J Surg Pathol. 20:342–348. 2012. View Article : Google Scholar : PubMed/NCBI
26	Cormio L, Sanguedolce F, Di Fino G, Massenio P, Liuzzi G, Ruocco N, Bufo P and Carrieri G: Asymptomatic bladder metastasis from breast cancer. Case Rep Urol. 2014:6725912014.PubMed/NCBI
27	Al Ibraheemi AA: Case report of metastatic invasive breast lobular carcinoma to the urinary bladder. Int J Hematol Oncol Stem Cell Res. 10:51–55. 2016.PubMed/NCBI
28	Yoneyama K, Nakagawa M and Hara A: Bladder metastasis from primary breast cancer: A case report. Surg Case Rep. 4:732018. View Article : Google Scholar : PubMed/NCBI
29	Mohammed S and Bua AA: Metastatic breast cancer to the urinary bladder in the caribbean. Case Rep Oncol. 14:1586–1590. 2021. View Article : Google Scholar : PubMed/NCBI
30	Haid M, Ignatoff J, Khandekar JD, Graham J and Holland J: Urinary bladder metastases from breast carcinoma. Cancer. 46:229–232. 1980. View Article : Google Scholar : PubMed/NCBI
31	Berger Y, Nissenblatt M, Salwitz J and Lega B: Bladder involvement in metastatic breast carcinoma. J Urol. 147:137–139. 1992. View Article : Google Scholar : PubMed/NCBI
32	Soon PS, Lynch W and Schwartz P: Breast cancer presenting initially with urinary incontinence: A case of bladder metastasis from breast cancer. Breast. 13:69–71. 2004. View Article : Google Scholar : PubMed/NCBI
33	Lawrentschuk N, Chan Y and Bolton DM: Metastatic breast cancer to the bladder. Breast J. 11:1432005. View Article : Google Scholar : PubMed/NCBI
34	Feldman PA, Madeb R, Naroditsky I, Halachmi S and Nativ O: Metastatic breast cancer to the bladder: A diagnostic challenge and review of the literature. Urology. 59:1382002. View Article : Google Scholar : PubMed/NCBI
35	Wang D, Jing T, Hui X and Yue W: A case report for Postoperative bladder metastasis of breast cancer. Chin J of Endourology. 16:89–90. 2022.
36	De Rose AF, Balzarini F, Mantica G, Toncini C and Terrone C: Late urinary bladder metastasis from breast cancer. Arch Ital Urol Androl. 91:60–62. 2019. View Article : Google Scholar : PubMed/NCBI
37	Gitau SN, Njau A and Mwanzi S: Urinary bladder metastasis from breast cancer: A rare cause of hematuria. BJR Case Rep. 6:201900482020.PubMed/NCBI
38	Pontes JE and Oldford JR: Metastatic breast carcinoma to the bladder. J Urol. 104:839–842. 1970. View Article : Google Scholar : PubMed/NCBI
39	Rigatti P, Broglia L, Montorsi F, Maffezzini M, Sironi M, Radice F, Abelli P, Pace M, Diamantini S, Veronesi AM, et al: Breast cancer metastases of the urinary bladder. Int J Tissue React. 13:159–163. 1991.PubMed/NCBI
40	Silverstein LI, Plaine L, Davis JE and Kabakow B: Breast carcinoma metastatic to bladder. Urology. 29:544–547. 1987. View Article : Google Scholar : PubMed/NCBI
41	Ryan PD, Harisinghani M, Lerwill MF and Kaufman DS: Case records of the Massachusetts General Hospital. Case 6-2006. A 71-year-old woman with urinary incontinence and a mass in the bladder. N Engl J Med. 354:850–856. 2006. View Article : Google Scholar : PubMed/NCBI
42	Williams JR, Stott MA and Moisey CU: Bilateral hydronephrosis secondary to breast carcinoma metastasising to the bladder. Br J Urol. 69:97–98. 1992. View Article : Google Scholar : PubMed/NCBI
43	Schneidau T, Stroumbakis N, Choudhury M, Eshgi M and Mallouh C: Metastatic breast cancer to the bladder: A case report. Int Urol Nephrol. 27:297–300. 1995. View Article : Google Scholar : PubMed/NCBI
44	Luczyńska E, Pawlik T, Chwalibóg A, Anioł J and Ryś J: Metastatic breast cancer to the bladder case report and review of literature. J Radiol Case Rep. 4:19–26. 2010.PubMed/NCBI
45	Reichman G, Michielsen DP and De Grève J: Tamoxifen to treat urge-incontinence from an isolated bladder metastasis of a primary breast cancer. Cent European J Urol. 65:36–37. 2012. View Article : Google Scholar : PubMed/NCBI
46	Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 71:209–249. 2021. View Article : Google Scholar : PubMed/NCBI
47	Wang R, Zhu Y, Liu X, Liao X, He J and Niu L: The Clinicopathological features and survival outcomes of patients with different metastatic sites in stage IV breast cancer. BMC Cancer. 19:10912019. View Article : Google Scholar : PubMed/NCBI
48	Kamat AM, Hahn NM, Efstathiou JA, Lerner SP, Malmström PU, Choi W, Guo CC, Lotan Y and Kassouf W: Bladder cancer. Lancet. 388:2796–2810. 2016. View Article : Google Scholar : PubMed/NCBI
49	Alfred Witjes J, Max Bruins H, Carrión A, Cathomas R, Compérat E, Efstathiou JA, Fietkau R, Gakis G, Lorch A, Martini A, et al: European Association of Urology guidelines on muscle-invasive and metastatic bladder cancer: Summary of the 2023 Guidelines. Eur Urol. 85:17–31. 2024. View Article : Google Scholar : PubMed/NCBI
50	Karaosmanoglu AD, Onur MR, Karcaaltincaba M, Akata D and Ozmen MN: Secondary tumors of the urinary system: An imaging conundrum. Korean J Radiol. 19:742–751. 2018. View Article : Google Scholar : PubMed/NCBI
51	Lodh B, Sinam RS and Singh KA: Adenocarcinoma of urinary bladder in patient with primary gastric cancer: An unusual synchronous distant metastasis. Indian J Cancer. 53:53–55. 2016. View Article : Google Scholar : PubMed/NCBI
52	Klinger ME: Secondary tumors of the genito-urinary tract. J Urol. 65:144–153. 1951. View Article : Google Scholar : PubMed/NCBI
53	Goldstein AG: Metastatic carcinoma to the bladder. J Urol. 98:209–215. 1967. View Article : Google Scholar : PubMed/NCBI
54	Barroso-Sousa R and Metzger-Filho O: Differences between invasive lobular and invasive ductal carcinoma of the breast: Results and therapeutic implications. Ther Adv Med Oncol. 8:261–266. 2016. View Article : Google Scholar : PubMed/NCBI
55	Rakha EA and Ellis IO: Lobular breast carcinoma and its variants. Semin Diagn Pathol. 27:49–61. 2010. View Article : Google Scholar : PubMed/NCBI
56	Makki J: Diversity of breast carcinoma: Histological subtypes and clinical relevance. Clin Med Insights Pathol. 8:23–31. 2015. View Article : Google Scholar : PubMed/NCBI
57	Roulot A, Héquet D, Guinebretière JM, Vincent-Salomon A, Lerebours F, Dubot C and Rouzier R: Tumoral heterogeneity of breast cancer. Ann Biol Clin (Paris). 74:653–660. 2016.PubMed/NCBI
58	Bevers TB, Niell BL, Baker JL, Bennett DL, Bonaccio E, Camp MS, Chikarmane S, Conant EF, Eghtedari M, Flanagan MR, et al: NCCN Guidelines^® Insights: Breast cancer screening and diagnosis, version 1.2023. J Natl Compr Canc Netw. 21:900–909. 2023. View Article : Google Scholar : PubMed/NCBI
59	Santinelli A, Pisa E, Stramazzotti D and Fabris G: HER-2 status discrepancy between primary breast cancer and metastatic sites. Impact on target therapy. Int J Cancer. 122:999–1004. 2008. View Article : Google Scholar : PubMed/NCBI
60	Mao QZ, Rong S, Xia MD, Li HZ and Zang MF: Bladder secondary carcinoma in female. Beijing Medicine. 26:312–314. 2004.
61	Karjol U, Jonnada P, Cherukuru S and Chandranath A: Bladder metastasis from breast cancer: A systematic review. Cureus. 12:e74082020.PubMed/NCBI