Exploring the prognostic significance of iron death‑related lncRNAs in colorectal cancer: A systematic review and meta‑analysis

Hang,Xiaoli; Du,Zhongxiang; Song,Jie

doi:10.3892/ol.2024.14417

Exploring the prognostic significance of iron death‑related lncRNAs in colorectal cancer: A systematic review and meta‑analysis

Authors:
- Xiaoli Hang
- Zhongxiang Du
- Jie Song
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Affiliations: Clinical Laboratory, The People's Hospital of Danyang, Affiliated Danyang Hospital of Nantong University, Danyang 212300, P.R. China, Clinical Laboratory, Nantong Fourth People's Hospital, Nantong, Jiangsu 226001, P.R. China
Published online on: April 26, 2024 https://doi.org/10.3892/ol.2024.14417
Article Number: 284
Copyright: © Hang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Colorectal cancer is a significant health challenge globally, with its prognosis associated with the profile of molecular biomarkers. Recently, the role of iron death‑associated long non‑coding (lnc)RNAs in cancer development has garnered attention; however, their expression patterns and prognostic value in colorectal cancer remain poorly elucidated. The present study aimed to assess the expression levels of iron death‑related lncRNAs in colorectal cancer tissues and evaluate their relationship with patient outcomes through a comprehensive meta‑analysis. Systematic searches were performed across multiple databases, including PubMed, Embase, Web of Science, Cochrane Library, CNKI, Wanfang and VIP databases, to identify studies relevant to the objective of the present study. Selected studies met predetermined inclusion criteria, from which data were extracted. R software version 4.3.1 was used for the meta‑analysis, evaluating the association between iron death‑related lncRNAs expression and colorectal cancer prognosis. Publication bias was assessed using funnel plot analysis, and Begg's and Egger's test. A total of 11 studies, including 3,984 patients with colorectal cancer, were included in the present meta‑analysis. The results demonstrated a significant association between iron death‑related lncRNAs and tumor stage classification [odds ratio (OR)=2.00; 95% confidence interval (CI), 1.77‑2.24]. Notably, a significant association was also revealed between iron death‑related lncRNAs and T stage classification in colorectal cancer (OR=1.82; 95% CI, 1.50‑2.20). Furthermore, a statistically significant association was demonstrated between iron death‑related lncRNAs and lymph node metastasis in colorectal cancer (OR=1.31; 95% CI, 1.03‑1.66). The findings also highlighted a significant association between iron death‑associated lncRNA and distant metastasis in colon cancer (OR=2.04; 95% CI, 1.62‑2.56). Moreover, a significant association between iron death‑related lncRNAs and risk score in colorectal cancer was revealed (OR=1.75; 95% CI, 1.25‑2.46). In conclusion, the findings of the present meta‑analysis underscore the potential of high ferroptosis‑associated lncRNA expression as an indicator of adverse outcomes in colorectal cancer, suggesting their viability as biomarkers for cancer progression and prognosis. This insight opens potential new avenues for clinical application and further research into colorectal cancer management.

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