Open Access

Therapeutic potential of esculetin in various cancer types (Review)

  • Authors:
    • Mengying Liu
    • Yuyan Sheng
    • Fangyue Guo
    • Jing Wu
    • Yufei Huang
    • Xiaoning Yang
    • Mengying Wang
    • Shanfeng Zhang
    • Pei Li
  • View Affiliations

  • Published online on: May 8, 2024     https://doi.org/10.3892/ol.2024.14438
  • Article Number: 305
  • Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 4.0].

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Abstract

Esculetin (Esc), a coumarin derivative and herbal medicinal compound used in traditional Chinese medicine, is extracted from Fraxinus chinensis. Esc has shown notable potential in the inhibition of proliferation, metastasis and cell cycle arrest in various cancer cell lines. The present review is based on research articles regarding Esc in the field of carcinoma, published between 2009 and 2023. These studies have unanimously demonstrated that Esc can effectively inhibit cancer cell proliferation through diverse mechanisms and modulate multiple signaling pathways, such as Wnt/β‑catenin, PI3K/Akt, MAPK and janus kinase/signal transducer and activator of transcription‑3. In addition, the safety profile of Esc has been demonstrated in credible animal experiments, which has indicated Esc as an effective compound. Furthermore, the combination therapy of Esc with commonly used chemotherapeutic drugs holds great promise. The aim of the present review was to encourage further studies and applications of Esc in cancer therapy.
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July-2024
Volume 28 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Liu M, Sheng Y, Guo F, Wu J, Huang Y, Yang X, Wang M, Zhang S and Li P: Therapeutic potential of esculetin in various cancer types (Review). Oncol Lett 28: 305, 2024.
APA
Liu, M., Sheng, Y., Guo, F., Wu, J., Huang, Y., Yang, X. ... Li, P. (2024). Therapeutic potential of esculetin in various cancer types (Review). Oncology Letters, 28, 305. https://doi.org/10.3892/ol.2024.14438
MLA
Liu, M., Sheng, Y., Guo, F., Wu, J., Huang, Y., Yang, X., Wang, M., Zhang, S., Li, P."Therapeutic potential of esculetin in various cancer types (Review)". Oncology Letters 28.1 (2024): 305.
Chicago
Liu, M., Sheng, Y., Guo, F., Wu, J., Huang, Y., Yang, X., Wang, M., Zhang, S., Li, P."Therapeutic potential of esculetin in various cancer types (Review)". Oncology Letters 28, no. 1 (2024): 305. https://doi.org/10.3892/ol.2024.14438