Open Access

Regorafenib plus programmed death‑1 inhibitors vs. regorafenib monotherapy in second‑line treatment for advanced hepatocellular carcinoma: A systematic review and meta‑analysis

  • Authors:
    • Zhao Li
    • Jie Wang
    • Jingbing Zhao
    • Zhengwei Leng
  • View Affiliations

  • Published online on: May 14, 2024     https://doi.org/10.3892/ol.2024.14451
  • Article Number: 318
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The present study compared the efficacy and safety of regorafenib plus programmed death‑1 inhibitors (R‑P) with regorafenib monotherapy as second‑line therapies for advanced hepatocellular carcinoma (HCC). A systematic search of relevant literature published in PubMed, Embase, Web of Science and Cochrane Library databases until October 2023 was conducted. Two authors independently performed data extraction and screening using standardized protocols. Stata/MP 17.0 was used for the meta‑analysis to evaluate the impact of R‑P treatment on major outcome indicators, including overall survival, progression‑free survival (PFS), tumor response and adverse reactions, in patients with advanced HCC. The results indicated that five cohort studies involving 444 patients with advanced HCC were included. The results revealed that R‑P treatment improved overall survival [hazard ratio (HR), 0.61; 95% confidence interval (CI) 0.48‑0.77; I2=0.0%; P=0.663] and PFS (HR, 0.51; 95% CI 0.41‑0.63; I2=17.5%; P=0.303). Additionally, it increased the objective response rate (risk ratio, 2.33; 95% CI, 1.49‑3.64; I2=0.0%; P=0.994) and disease control rate (HR, 1.40; 95% CI, 1.20‑1.63; I2=0.0%; P=0.892) compared with those of regorafenib. However, R‑P treatment was associated with an increased incidence of adverse events, such as hypothyroidism, thrombocytopenia and rash, compared with that in regorafenib. In conclusion, R‑P is superior to regorafenib monotherapy in terms of survival benefits and tumor response.
View Figures
View References

Related Articles

Journal Cover

July-2024
Volume 28 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Li Z, Wang J, Zhao J and Leng Z: Regorafenib plus programmed death‑1 inhibitors vs. regorafenib monotherapy in second‑line treatment for advanced hepatocellular carcinoma: A systematic review and meta‑analysis. Oncol Lett 28: 318, 2024
APA
Li, Z., Wang, J., Zhao, J., & Leng, Z. (2024). Regorafenib plus programmed death‑1 inhibitors vs. regorafenib monotherapy in second‑line treatment for advanced hepatocellular carcinoma: A systematic review and meta‑analysis. Oncology Letters, 28, 318. https://doi.org/10.3892/ol.2024.14451
MLA
Li, Z., Wang, J., Zhao, J., Leng, Z."Regorafenib plus programmed death‑1 inhibitors vs. regorafenib monotherapy in second‑line treatment for advanced hepatocellular carcinoma: A systematic review and meta‑analysis". Oncology Letters 28.1 (2024): 318.
Chicago
Li, Z., Wang, J., Zhao, J., Leng, Z."Regorafenib plus programmed death‑1 inhibitors vs. regorafenib monotherapy in second‑line treatment for advanced hepatocellular carcinoma: A systematic review and meta‑analysis". Oncology Letters 28, no. 1 (2024): 318. https://doi.org/10.3892/ol.2024.14451