Superficial CD34<sup>+</sup> fibroblastic tumor with focal atypical presentation: A case report

Sun,Juan; Huang,Shengliang; Yang,Xiaoqing

doi:10.3892/ol.2024.14468

Superficial CD34⁺ fibroblastic tumor with focal atypical presentation: A case report

Authors:
- Juan Sun
- Shengliang Huang
- Xiaoqing Yang
View Affiliations

Affiliations: Department of Dermatology, Jinan First People's Hospital, Jinan, Shandong 250014, P.R. China, Department of Urology, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, Shandong 250014, P.R. China, Department of Pathology, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, Shandong 250014, P.R. China
Published online on: May 22, 2024 https://doi.org/10.3892/ol.2024.14468
Article Number: 335
Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

Superficial CD34⁺ fibroblastic tumors (SCPFTs) are rare mesenchymal tumors with distinct morphological features. Although several cases of SCPFT have been reported, a comprehensive understanding of its clinical and biological features necessitates the inclusion of additional cases. The current study presents a case of SCPFT, where morphological observations, immunohistochemical staining and fluorescence in situ hybridization (FISH) were performed. Immunohistochemistry revealed diffuse CD34 expression and integrase interactor 1 expression, whilst FISH indicated rearrangement of the PR/SET domain 10 gene. Microscopic assessment demonstrated typical SCPFT pathology, with a focal nodular region showing a high Ki‑67 index, suggesting heterogeneity and the potential for local recurrence. The present study also briefly reviews the differential diagnosis of tumors with morphological similarities. It was found that the precise diagnosis of SCPFT relies on the distinctive pathological features, the use of immunohistochemical markers, including CD34 staining, and the differentiation from similar histological lesions.

View Figures

View References

1	Salah HT, D'Ardis JA, Baek D, Duran J, Schwartz MR, Ayala AG and Ro JY: Case of recurrent superficial CD34-positive fibroblastic tumor. J Cutan Pathol. 50:477–480. 2023. View Article : Google Scholar : PubMed/NCBI
2	Carter JM, Weiss SW, Linos K, DiCaudo DJ and Folpe AL: Superficial CD34-positive fibroblastic tumor: Report of 18 cases of a distinctive low-grade mesenchymal neoplasm of intermediate (borderline) malignancy. Mod Pathol. 27:294–302. 2014. View Article : Google Scholar : PubMed/NCBI
3	WHO Classification of Tumours, . Soft Tissue and Bone Tumours. IARC Press; France: 2020
4	Salah HT, D'ardis JA, Baek D, Schwartz MR, Ayala AG and Ro JY: Superficial CD34-positive fibroblastic tumor (SCPFT): A review of pathological and clinical features. Ann Diagn Pathol. 58:1519372022. View Article : Google Scholar : PubMed/NCBI
5	Anderson WJ, Mertens F, Mariño-Enríquez A, Hornick JL and Fletcher CD: Superficial CD34-positive fibroblastic tumor: A clinicopathologic, immunohistochemical, and molecular study of 59 cases. Am J Surg Pathol. 46:1329–1339. 2022. View Article : Google Scholar : PubMed/NCBI
6	Li W, Molnar SL, Mott M, White E and De Las Casas LE: Superficial CD34-positive fibroblastic tumor: Cytologic features, tissue correlation, ancillary studies, and differential diagnosis of a recently described soft tissue neoplasm. Diagn Cytopathol. 44:926–930. 2016. View Article : Google Scholar : PubMed/NCBI
7	Lao IW, Yu L and Wang J: Superficial CD34-positive fibroblastic tumour: A clinicopathological and immunohistochemical study of an additional series. Histopathology. 70:394–401. 2017. View Article : Google Scholar : PubMed/NCBI
8	Perret R, Michal M, Carr RA, Velasco V, Švajdler M, Karanian M, Meurgey A, Paindavoine S, Soubeyran I, Coindre JM, et al: Superficial CD34-positive fibroblastic tumor and PRDM10-rearranged soft tissue tumor are overlapping entities: A comprehensive study of 20 cases. Histopathology. 79:810–825. 2021. View Article : Google Scholar : PubMed/NCBI
9	Sood N and Khandelia BK: Superficial CD34-positive fibroblastic tumor: A new entity; case report and review of literature. Indian J Pathol Microbiol. 60:377–380. 2017. View Article : Google Scholar : PubMed/NCBI
10	Rekhi B, Banerjee D, Gala K and Gulia A: Superficial CD34-positive fibroblastic tumor in the forearm of a middle-aged patient: A newly described, rare soft-tissue tumor. Indian J Pathol Microbiol. 61:421–424. 2018. View Article : Google Scholar : PubMed/NCBI
11	Hamada T, Katsuki N, Hosokawa Y, Ayano Y and Ikeda M: Additional case of superficial CD34-positive fibroblastic tumor in a Japanese patient. J Dermatol. 46:e134–e136. 2019. View Article : Google Scholar : PubMed/NCBI
12	Batur S, Ozcan K, Ozcan G, Tosun I and Comunoglu N: Superficial CD34 positive fibroblastic tumor: Report of three cases and review of the literature. Int J Dermatol. 58:416–422. 2019. View Article : Google Scholar : PubMed/NCBI
13	Ding L, Xu WJ, Tao XY, Zhang L and Cai ZG: Clinicopathological features of superficial CD34-positive fibroblastic tumor. World J Clin Cases. 9:2739–2750. 2021. View Article : Google Scholar : PubMed/NCBI
14	Li SY, Zhang HL and Bai YZ: Superficial CD34-positive fibroblastic tumor on the chest wall of an 8-year-old girl: A case report and literature review. Pediatr Hematol Oncol. 38:602–608. 2021. View Article : Google Scholar : PubMed/NCBI
15	Mao X, Sun YY, Deng ML, Ma T and Yu L: Superficial CD34-positive fibroblastic tumor: Report of two cases and review of literature. Int J Clin Exp Pathol. 13:38–43. 2020.PubMed/NCBI
16	Andrei V, Haefliger S and Baumhoer D: Superficial mesenchymal tumours expressing epithelial markers on immunohistochemistry: Diagnostic clues and pitfalls. Semin Diagn Pathol. 40:238–245. 2023. View Article : Google Scholar : PubMed/NCBI
17	Puls F, Carter JM, Pillay N, McCulloch TA, Sumathi VP, Rissler P, Fagman H, Hansson M, Amary F, Tirabosco R, et al: Overlapping morphological, immunohistochemical and genetic features of superficial CD34-positive fibroblastic tumor and PRDM10-rearranged soft tissue tumor. Mod Pathol. 35:767–776. 2022. View Article : Google Scholar : PubMed/NCBI
18	Hofvander J, Tayebwa J, Nilsson J, Magnusson L, Brosjö O, Larsson O, von Steyern FV, Mandahl N, Fletcher CD and Mertens F: Recurre2nt PRDM10 gene fusions in undifferentiated pleomorphic sarcoma. Clin Cancer Res. 21:864–869. 2015. View Article : Google Scholar : PubMed/NCBI
19	Zhao M, Yin X, He H, Fan Y, Ru G and Meng X: Recurrent PRDM10 fusions in superficial CD34-positive fibroblastic tumors: A clinicopathologic and molecular study of 10 additional cases of an emerging novel entity. Am J Clin Pathol. 159:367–378. 2023. View Article : Google Scholar : PubMed/NCBI
20	Rayyan MM, Aboushelib M, Sayed NM, Ibrahim A and Jimbo R: Comparison of interim restorations fabricated by CAD/CAM with those fabricated manually. J Prosthet Dent. 114:414–419. 2015. View Article : Google Scholar : PubMed/NCBI
21	Kaddu S, McMenamin ME and Fletcher CD: Atypical fibrous histiocytoma of the skin: Clinicopathologic analysis of 59 cases with evidence of infrequent metastasis. Am J Surg Pathol. 26:35–46. 2002. View Article : Google Scholar : PubMed/NCBI
22	Michal M, Kazakov DV, Hadravský L, Agaimy A, Švajdler M, Kuroda N and Michal M: Pleomorphic hyalinizing angiectatic tumor revisited: All tumors manifest typical morphologic features of myxoinflammatory fibroblastic sarcoma, further suggesting 2 morphologic variants of a single entity. Ann Diagn Pathol. 20:40–43. 2016. View Article : Google Scholar : PubMed/NCBI
23	Gru AA and Cruz DJ: Atypical fibroxanthoma: A selective review. Semin Diagn Pathol. 30:4–12. 2013. View Article : Google Scholar : PubMed/NCBI
24	Kohashi K, Yamada Y, Hotokebuchi Y, Yamamoto H, Taguchi T, Iwamoto Y and Oda Y: ERG and SALL4 expressions in SMARCB1/INI1-deficient tumors: A useful tool for distinguishing epithelioid sarcoma from malignant rhabdoid tumor. Hum Pathol. 46:225–230. 2015. View Article : Google Scholar : PubMed/NCBI
25	Kodera K, Hoshino M, Takahashi S, Hidaka S, Kogo M, Hashizume R, Imakita T, Ishiyama M, Ogawa M and Eto K: Surgical management of primary undifferentiated pleomorphic sarcoma of the rectum: A case report and review of the literature. World J Surg Oncol. 20:1992022. View Article : Google Scholar : PubMed/NCBI
26	Ríos-Viñuela E, Serra-Guillén C, Llombart B, Requena C, Nagore E, Traves V, Guillén C, Vázquez D and Sanmartín O: Pleomorphic dermal sarcoma: A retrospective study of 16 cases in a dermato-oncology centre and a review of the literature. Eur J Dermatol. 30:545–553. 2020. View Article : Google Scholar : PubMed/NCBI
27	Ieremia E and Thway K: Myxoinflammatory fibroblastic sarcoma: Morphologic and genetic updates. Arch Pathol Lab Med. 138:1406–1411. 2014. View Article : Google Scholar : PubMed/NCBI
28	Díaz-Flores L, Gutiérrez R, García MP, Sáez FJ, Díaz-Flores L Jr, Valladares F and Madrid JF: CD34+ stromal cells/fibroblasts/fibrocytes/telocytes as a tissue reserve and a principal source of mesenchymal cells. Location, morphology, function and role in pathology. Histol Histopathol. 29:831–870. 2014.PubMed/NCBI
29	Tindle RW, Nichols RA, Chan L, Campana D, Catovsky D and Birnie GD: A novel monoclonal antibody BI-3C5 recognises myeloblasts and non-B non-T lymphoblasts in acute leukaemias and CGL blast crises, and reacts with immature cells in normal bone marrow. Leuk Res. 9:1–9. 1985. View Article : Google Scholar : PubMed/NCBI
30	Brown J, Greaves MF and Molgaard HV: The gene encoding the stem cell antigen, CD34, is conserved in mouse and expressed in haemopoietic progenitor cell lines, brain, and embryonic fibroblasts. Int Immunol. 3:175–184. 1991. View Article : Google Scholar : PubMed/NCBI
31	Radu P, Zurzu M, Paic V, Bratucu M, Garofil D, Tigora A, Georgescu V, Prunoiu V, Pasnicu C, Popa F, et al: CD34-Structure, functions and relationship with cancer stem cells. Medicina (Kaunas). 59:9382023. View Article : Google Scholar : PubMed/NCBI
32	Krause DS, Fackler MJ, Civin CI and May WS: CD34: Structure, biology, and clinical utility. Blood. 87:1–13. 1996. View Article : Google Scholar : PubMed/NCBI