Open Access

Effectiveness and safety of segmentectomy vs. wedge resection for the treatment of patients with operable non‑small cell lung cancer: A meta‑analysis and systematic review

  • Authors:
    • Jiawei Xiu
    • Shiqi Wang
    • Xilong Wang
    • Wei Xu
    • Yuhang Hu
    • Yujuan Hua
    • Shiguang Xu
  • View Affiliations

  • Published online on: May 24, 2024     https://doi.org/10.3892/ol.2024.14469
  • Article Number: 336
  • Copyright : © Xiu et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

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Abstract

The present study compared the differences in effectiveness and safety between segmentectomy (ST) and wedge resection (WR) in patients with operable non‑small cell lung cancer (NSCLC). The PubMed, EMBASE, Cochrane Library and Web of Science databases were searched for papers published from inception until July 2023. The inclusion criteria were based on the population, intervention, comparator, outcomes and study designs. ROBINS‑I was selected to assess the risk of bias and quality of evidence in the included non‑randomised studies. Appropriate effect sizes were selected, and subgroup analyses, heterogeneity tests, sensitivity analyses and publication bias were applied. A total of 18 retrospective studies were included, involving 19,381 patients with operable NSCLC. The 5‑year overall survival rate [hazard ratio (HR), 0.19; 95% confidence interval (CI), 0.04, 0.34; P=0.014; I2=76.3%], lung cancer‑specific survival rate (HR, 0.3; 95% CI, 0.21, 0.38; P<0.01; I2=13.8%) and metastasis rate [odds ratio (OR), 1.56; 95% CI, 1.03, 2.38; P=0.037] in patients with operable NSCLC treated with WR were worse than those in patients treated with ST. The incidence of postoperative complications (OR, 0.44; 95% CI, 0.23, 0.82) in the WR group was lower than in the ST treatment group. There was no difference in postoperative recurrence (OR, 2.15; 95% CI, 0.97, 4.74; P=0.058) and mortality (risk difference, 0.04; 95% CI, ‑0.03, 0.11; P=0.287) between groups. Based on current evidence, patients with NSCLC treated with ST surgery have better postoperative survival but more complications than those patients treated with WT, while the effect of WR and ST on the recurrence rate and distant metastasis rate remains controversial.
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July-2024
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Spandidos Publications style
Xiu J, Wang S, Wang X, Xu W, Hu Y, Hua Y and Xu S: Effectiveness and safety of segmentectomy vs. wedge resection for the treatment of patients with operable non‑small cell lung cancer: A meta‑analysis and systematic review. Oncol Lett 28: 336, 2024.
APA
Xiu, J., Wang, S., Wang, X., Xu, W., Hu, Y., Hua, Y., & Xu, S. (2024). Effectiveness and safety of segmentectomy vs. wedge resection for the treatment of patients with operable non‑small cell lung cancer: A meta‑analysis and systematic review. Oncology Letters, 28, 336. https://doi.org/10.3892/ol.2024.14469
MLA
Xiu, J., Wang, S., Wang, X., Xu, W., Hu, Y., Hua, Y., Xu, S."Effectiveness and safety of segmentectomy vs. wedge resection for the treatment of patients with operable non‑small cell lung cancer: A meta‑analysis and systematic review". Oncology Letters 28.1 (2024): 336.
Chicago
Xiu, J., Wang, S., Wang, X., Xu, W., Hu, Y., Hua, Y., Xu, S."Effectiveness and safety of segmentectomy vs. wedge resection for the treatment of patients with operable non‑small cell lung cancer: A meta‑analysis and systematic review". Oncology Letters 28, no. 1 (2024): 336. https://doi.org/10.3892/ol.2024.14469