Gastric‑type endocervical adenocarcinoma: A report of two cases

Wang,Qian; Li,Yanyu; Kan,Guangjuan; Fu,Xiaofeng; Wang,Minyan; Zhu,Jiang

doi:10.3892/ol.2024.14477

Gastric‑type endocervical adenocarcinoma: A report of two cases

Authors:
- Qian Wang
- Yanyu Li
- Guangjuan Kan
- Xiaofeng Fu
- Minyan Wang
- Jiang Zhu
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Affiliations: Department of Ultrasound Medicine, The First People's Hospital of Linhai City, Linhai, Zhejiang 317000, P.R. China, Department of Ultrasound Medicine, and State Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases, Women's Hospital School of Medicine Zhejiang University, Hangzhou, Zhejiang 310000, P.R. China, Department of Ultrasound Medicine, and State Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases, Women's Hospital School of Medicine Zhejiang University, Hangzhou, Zhejiang 310000, P.R. China
Published online on: May 30, 2024 https://doi.org/10.3892/ol.2024.14477
Article Number: 344
Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Gastric‑type endocervical adenocarcinoma (GEA) is an uncommon and highly aggressive malignancy, characterized by non‑specific clinical manifestations. The limited number of documented cases poses significant challenges in achieving an early preoperative diagnosis. In the present study, two cases of GEA in female patients, aged 46 and 39 years, who presented with the chief complaint of profuse vaginal discharge are described. Both patients underwent a total hysterectomy and bilateral adnexectomy, leading to the definitive diagnosis of GEA through routine pathological and immunohistochemical examination. Following surgery, case one received conventional chemotherapy with paclitaxel and carboplatin, demonstrating no evidence of recurrence during a follow‑up period of >2 years. At present, patient B has been followed up for >1 year without any signs of disease recurrence. Given the rarity and diagnostic challenges associated with GEA, further investigations into its pathogenesis and diagnostic modalities are warranted. Additionally, due to its poor prognosis, close surveillance is essential for monitoring potential recurrences. Reporting such cases is crucial in aiding clinicians to make accurate diagnoses and treatment decisions.

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