Open Access

Skin metastasis from ovarian cancer with somatic BRCA1 mutation: A case report and literature review

  • Authors:
    • Jingheng Zhang
    • Wenfeng He
    • Zhenhua Zhang
    • Hui Dong
    • Xiangyu Deng
    • Qinglian Wen
    • Dan Li
  • View Affiliations

  • Published online on: June 3, 2024     https://doi.org/10.3892/ol.2024.14481
  • Article Number: 348
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Skin metastasis from ovarian cancer is rare, and its prognosis is poor. Effective therapeutic strategies are currently lacking, but the combination of various treatment methods shrink the tumor and relieve symptoms. The present study reports a rare case of advanced ovarian cancer with skin metastases and intestinal wall thickening, along with a BRCA1 DNA repair associated (BRCA1) mutation. After standard first‑line treatment and non‑standard second‑line treatment, the patient developed skin metastases. The patient's skin itching, pain and lesions were completely relieved after administering bevacizumab in combination with paclitaxel and carboplatin. After 4 months, skin metastases recurred along with anal distension during maintenance treatment with oral poly(ADP ribose) polymerase (PARP) inhibitors. The patient was treated again with bevacizumab combined with docetaxel, and the anal distension was significantly relieved. Angiogenesis therapy combined with chemotherapy is effective, but that the disease‑free survival time is short, and PARP inhibitor maintenance effect is limited even in cases with a BRCA1 gene mutation.
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August-2024
Volume 28 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Zhang J, He W, Zhang Z, Dong H, Deng X, Wen Q and Li D: Skin metastasis from ovarian cancer with somatic BRCA1 mutation: A case report and literature review. Oncol Lett 28: 348, 2024
APA
Zhang, J., He, W., Zhang, Z., Dong, H., Deng, X., Wen, Q., & Li, D. (2024). Skin metastasis from ovarian cancer with somatic BRCA1 mutation: A case report and literature review. Oncology Letters, 28, 348. https://doi.org/10.3892/ol.2024.14481
MLA
Zhang, J., He, W., Zhang, Z., Dong, H., Deng, X., Wen, Q., Li, D."Skin metastasis from ovarian cancer with somatic BRCA1 mutation: A case report and literature review". Oncology Letters 28.2 (2024): 348.
Chicago
Zhang, J., He, W., Zhang, Z., Dong, H., Deng, X., Wen, Q., Li, D."Skin metastasis from ovarian cancer with somatic BRCA1 mutation: A case report and literature review". Oncology Letters 28, no. 2 (2024): 348. https://doi.org/10.3892/ol.2024.14481