Open Access

Exploring the potential of the TCR repertoire as a tumor biomarker (Review)

  • Authors:
    • An-Li Huang
    • Yan-Zhao He
    • Yong Yang
    • Min Pang
    • Guo-Ping Zheng
    • Hai-Long Wang
  • View Affiliations

  • Published online on: June 28, 2024     https://doi.org/10.3892/ol.2024.14546
  • Article Number: 413
  • Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

T cells play an important role in adaptive immunity. Mature T cells specifically recognize antigens on major histocompatibility complex molecules through T‑cell receptors (TCRs). As the TCR repertoire is highly diverse, its analysis is vital in the assessment of T cells. Advances in sequencing technology have provided convenient methods for further investigation of the TCR repertoire. In the present review, the TCR structure and the mechanisms by which TCRs function in tumor recognition are described. In addition, the potential value of the TCR repertoire in tumor diagnosis is reviewed. Furthermore, the role of the TCR repertoire in tumor immunotherapy is introduced, and the relationships between the TCR repertoire and the effects of different tumor immunotherapies are discussed. Based on the reviewed literature, it may be concluded that the TCR repertoire has the potential to serve as a biomarker for tumor prognosis. However, a wider range of cancer types and more diverse subjects require evaluation in future research to establish the TCR repertoire as a biomarker of tumor immunity.
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September-2024
Volume 28 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Huang A, He Y, Yang Y, Pang M, Zheng G and Wang H: Exploring the potential of the TCR repertoire as a tumor biomarker (Review). Oncol Lett 28: 413, 2024.
APA
Huang, A., He, Y., Yang, Y., Pang, M., Zheng, G., & Wang, H. (2024). Exploring the potential of the TCR repertoire as a tumor biomarker (Review). Oncology Letters, 28, 413. https://doi.org/10.3892/ol.2024.14546
MLA
Huang, A., He, Y., Yang, Y., Pang, M., Zheng, G., Wang, H."Exploring the potential of the TCR repertoire as a tumor biomarker (Review)". Oncology Letters 28.3 (2024): 413.
Chicago
Huang, A., He, Y., Yang, Y., Pang, M., Zheng, G., Wang, H."Exploring the potential of the TCR repertoire as a tumor biomarker (Review)". Oncology Letters 28, no. 3 (2024): 413. https://doi.org/10.3892/ol.2024.14546