Open Access

Comparing survival after proximal gastrectomy vs. total gastrectomy in advanced gastric cancer: A systematic review and meta‑analysis

  • Authors:
    • Ping-Jui Su
    • Yen-Ta Huang
    • Ting-Kai Liao
    • Wei-Hsun Lu
    • Chih-Jung Wang
    • Ying-Jui Chao
    • Yan-Shen Shan
  • View Affiliations

  • Published online on: July 5, 2024     https://doi.org/10.3892/ol.2024.14560
  • Article Number: 427
  • Copyright: © Su et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present systematic review and meta‑analysis aimed to compare long‑term survival after proximal gastrectomy (PG) and total gastrectomy (TG) for locally advanced proximal gastric cancer (GC). The PubMed, EMBASE and Cochrane CENTRAL databases were searched from their inception to May 2023. Only published two‑arm prospective or retrospective studies were included. The selected studies included patients with locally advanced GC who underwent PG or TG and reported quantitative survival outcomes. The primary outcome was overall survival (OS) after gastrectomy. Three studies involving a total of 4,815 patients met the inclusion criteria. The age of the patients ranged from 57.03‑64.46 years and 78.80% were male. The estimated 5‑year OS probability after TG varied from 30.14 to 72.0%, and from 42.06 to 74.9% after PG. Results of the meta‑analyses revealed a significant association between PG and improved OS compared with that of TG, with a pooled hazard ratio of 1.15 (95% CI, 1.05‑1.25). No heterogeneity was observed in the included studies (I2=0%). Overall, in managing locally advanced GC, PG demonstrated comparable or marginally improved OS compared with TG during postoperative follow‑up; however, further meta-analyses are required to provide stronger evidence.
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September-2024
Volume 28 Issue 3

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Spandidos Publications style
Su P, Huang Y, Liao T, Lu W, Wang C, Chao Y and Shan Y: Comparing survival after proximal gastrectomy vs. total gastrectomy in advanced gastric cancer: A systematic review and meta‑analysis. Oncol Lett 28: 427, 2024.
APA
Su, P., Huang, Y., Liao, T., Lu, W., Wang, C., Chao, Y., & Shan, Y. (2024). Comparing survival after proximal gastrectomy vs. total gastrectomy in advanced gastric cancer: A systematic review and meta‑analysis. Oncology Letters, 28, 427. https://doi.org/10.3892/ol.2024.14560
MLA
Su, P., Huang, Y., Liao, T., Lu, W., Wang, C., Chao, Y., Shan, Y."Comparing survival after proximal gastrectomy vs. total gastrectomy in advanced gastric cancer: A systematic review and meta‑analysis". Oncology Letters 28.3 (2024): 427.
Chicago
Su, P., Huang, Y., Liao, T., Lu, W., Wang, C., Chao, Y., Shan, Y."Comparing survival after proximal gastrectomy vs. total gastrectomy in advanced gastric cancer: A systematic review and meta‑analysis". Oncology Letters 28, no. 3 (2024): 427. https://doi.org/10.3892/ol.2024.14560