Role of AMIGO2 in cancer progression: Novel insights (Review)
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- Published online on: July 12, 2024 https://doi.org/10.3892/ol.2024.14567
- Article Number: 434
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Copyright: © Tian et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
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Abstract
Adhesion molecule with IgG‑like domain 2 (AMIGO2) is a novel scaffold protein initially identified in cerebellar granule neurons, and inhibits apoptosis of neurons. It is also widely expressed in various malignant tumors, including gastric cancer, colorectal carcinoma, ovarian cancer, prostate cancer and melanoma. During the past decades, it has been revealed that AMIGO2 can act as an oncogene, participating in tumor occurrence and development, for example by inhibiting apoptosis, accelerating cell proliferation, migration and adhesion, and promoting tumor metastasis and drug resistance. The present review discusses the recent advancements regarding AMIGO2 in the field of cancer, emphasizing its related molecular mechanisms to identify novel therapeutic strategies targeting AMIGO2 for cancer treatment in the future.
