The ability of nutrition and immune‑related biomarkers to predict outcomes in patients with locally advanced rectal cancer (LARC) treated with neoadjuvant therapy followed by surgery remains controversial due to the lack of evidence regarding the accuracy and reliability of these biomarkers in predicting outcomes for such patients. Therefore, the present study aimed to investigate the prognostic potential of nutrition and immune‑related biomarkers in patients with LARC who underwent chemoradiotherapy followed by curative surgery. The clinical data of patients with LARC treated with neoadjuvant therapy followed by surgery between January 2010 and December 2019 were analyzed. In total, 214 consecutive patients were enrolled into the present study, who were then categorized into low and high prognostic nutritional index (PNI) groups. The X‑tile 3.6.1 program was used to calculate and then determine the optimal cut‑off values for PNI. Disease‑free survival (DFS) and overall survival (OS) were compared between the low and high PNI groups. Cox regression analysis demonstrated that low PNI and high post‑chemoradiotherapy carcinoembryonic antigen levels were significantly associated with reduced disease‑free survival and overall survival. Specifically, a low PNI was associated with inferior 5‑year DFS (P=0.025) and OS (P=0.018). These findings suggest that amongst the nutritional and immune‑related biomarkers, PNI is a significant predictive factor for disease recurrence and mortality in patients with LARC treated with neoadjuvant therapy followed by surgery.

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