Renal cell carcinoma preceded by a rheumatoid‑like paraneoplastic syndrome: A case report

Yoshimura,Yusuke; Suwabe,Tatsuya; Miki,Katsuyuki; Yokoyama,Takayoshi; Kono,Kei; Kinowaki,Keiichi; Kato,Ikuma; Nagashima,Yoji; Nishikori,Asami; Sato,Yasuharu; Kurihara,Shigekazu; Oba,Yuki; Mizuno,Hiroki; Sekine,Akinari; Yamanouchi,Masayuki; Kamiyama,Manabu; Ishii,Yasuo; Nakamura,Yuki; Ubara,Yoshifumi; Sawa,Naoki

doi:10.3892/ol.2024.14581

Renal cell carcinoma preceded by a rheumatoid‑like paraneoplastic syndrome: A case report

Authors:
- Yusuke Yoshimura
- Tatsuya Suwabe
- Katsuyuki Miki
- Takayoshi Yokoyama
- Kei Kono
- Keiichi Kinowaki
- Ikuma Kato
- Yoji Nagashima
- Asami Nishikori
- Yasuharu Sato
- Shigekazu Kurihara
- Yuki Oba
- Hiroki Mizuno
- Akinari Sekine
- Masayuki Yamanouchi
- Manabu Kamiyama
- Yasuo Ishii
- Yuki Nakamura
- Yoshifumi Ubara
- Naoki Sawa
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Affiliations: Nephrology Center, Toranomon Hospital Kajigaya, Kawasaki, Kanagawa 213‑8587, Japan, Department of Pathology, Toranomon Hospital, Tokyo 105‑8470, Japan, Department of Molecular Pathology, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa 236‑0004, Japan, Department of Surgical Pathology, Tokyo Women's Medical University, Tokyo 162‑8666, Japan, Department of Molecular Hematopathology, Okayama University Graduate School of Health Sciences, Okayama 700‑8530, Japan, Department of Urology, Toranomon Hospital Kajigaya, Kawasaki, Kanagawa 213‑8587, Japan
Published online on: July 22, 2024 https://doi.org/10.3892/ol.2024.14581
Article Number: 448

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Abstract

A man with polycystic kidney disease and a history of renal transplantation at the age of 55 years developed seronegative rheumatoid arthritis (RA) at the age of 68 years. Treatment with a biological derivative led to remission; however, the patient relapsed 2 years later. After being switched to baricitinib, the patient again achieved remission. After 2 years, when the patient was aged 72 years, RA recurred, and the right native kidney became enlarged due to the presence of a large tumor. Surgical nephrectomy was performed, and the tumor was classified as renal cell carcinoma (RCC), not otherwise specified. The cancer tissue comprised sarcomatoid and rhabdoid cells with marked neutrophil infiltration, and the tumor cells were positive for interleukin‑6. The patient, aged 73 years, experienced a resolution of joint pain following surgical intervention; however, they died because of systemic metastases ~10 weeks post‑operation. Based on the clinical course, the RA‑like lesions and subsequent RCC were considered to represent a paraneoplastic syndrome.