Open Access

Sarcomatoid carcinoma of the pancreas (Review)

  • Authors:
    • Yijie Ma
    • Yiwen Yang
    • Huizhi Zhang
    • Joseph Mugaanyi
    • Yangke Hu
    • Shengdong Wu
    • Caide Lu
    • Shuqi Mao
    • Ke Wang
  • View Affiliations

  • Published online on: August 5, 2024     https://doi.org/10.3892/ol.2024.14610
  • Article Number: 477
  • Copyright: © Ma et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Sarcomatoid carcinoma of the pancreas (SCP) is a rare and aggressive subtype of undifferentiated pancreatic ductal adenocarcinoma, with a generally poor prognosis and only sporadic cases reported worldwide. Histologically, the most notable feature of SCP is the presence of abundant of mesenchymatoid spindle tumor cells in the tumor, which lack glandular differentiation. Immunohistochemically, SCP is characterized by the expression of both mesenchymal and epithelial markers. With only a few reported cases, there is limited knowledge about its molecular and clinicopathological characteristics. Therefore, the present study performed a literature search to identify all relevant published studies. The present review provides an overview of the histogenesis, diagnosis, genetic features, prognosis and treatment of SCP, specifically focusing on the molecular alterations. Furthermore, a single‑center experience is reported, which adds to the limited evidence available in the literature.
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October-2024
Volume 28 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Ma Y, Yang Y, Zhang H, Mugaanyi J, Hu Y, Wu S, Lu C, Mao S and Wang K: Sarcomatoid carcinoma of the pancreas (Review). Oncol Lett 28: 477, 2024.
APA
Ma, Y., Yang, Y., Zhang, H., Mugaanyi, J., Hu, Y., Wu, S. ... Wang, K. (2024). Sarcomatoid carcinoma of the pancreas (Review). Oncology Letters, 28, 477. https://doi.org/10.3892/ol.2024.14610
MLA
Ma, Y., Yang, Y., Zhang, H., Mugaanyi, J., Hu, Y., Wu, S., Lu, C., Mao, S., Wang, K."Sarcomatoid carcinoma of the pancreas (Review)". Oncology Letters 28.4 (2024): 477.
Chicago
Ma, Y., Yang, Y., Zhang, H., Mugaanyi, J., Hu, Y., Wu, S., Lu, C., Mao, S., Wang, K."Sarcomatoid carcinoma of the pancreas (Review)". Oncology Letters 28, no. 4 (2024): 477. https://doi.org/10.3892/ol.2024.14610