Male breast cancer metastasising to the liver: A case report

Jiang,Mingming; Li,Linyun; Liu,Hongjie; Xie,Hua

doi:10.3892/ol.2024.14663

Male breast cancer metastasising to the liver: A case report

Authors:
- Mingming Jiang
- Linyun Li
- Hongjie Liu
- Hua Xie
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Affiliations: Department of Oncology, Xuancheng Hospital Affiliated to Wannan Medical College, Xuancheng, Anhui 242000, P.R. China
Published online on: September 3, 2024 https://doi.org/10.3892/ol.2024.14663
Article Number: 530
Copyright: © Jiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Breast cancer (BC) remains one of the most common malignant diseases affecting female patients, and it can metastasize to nearly every part of the body. BC is rare in men, and therefore men rarely develop BC liver metastases (BCLMs). However, the present study reports a 55‑year‑old male patient who underwent surgery 5 years ago for BC. After treatment, the patient was actively followed up regularly. Recently, the patient was examined for chest tightness, and liver space‑occupying lesions were found. The upper abdominal enhanced computed tomography images of the patient showed that the liver density was not uniform and that the liver had a mass. A crude needle biopsy was used to examine the liver tumour under the guidance of ultrasound. The pathology revealed that the patient was positive for E‑cadherin, oestrogen receptor, progesterone receptor, human epidermal growth factor receptor 2, GATA binding protein 3 and CK7. The patient was subsequently diagnosed with BCLM. The patient was treated with doxorubicin hydrochloride, cyclophosphamide, Docetaxel and followed up regularly. The present case report emphasizes that BC is found not only in women but also in an increasing number of men, and that liver metastasis can occur in males with BC. BCLM is a complex process, and therefore it is hoped this case report will improve the understanding of male BCLM and the mechanism of this disease.

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1	Diaby V, Tawk R, Sanogo V, Xiao H and Montero AJ: A review of systematic reviews of the cost-effectiveness of hormone therapy, chemotherapy, and targeted therapy for breast cancer. Breast Cancer Res Treat. 151:27–40. 2015. View Article : Google Scholar : PubMed/NCBI
2	Tarver T: Breast cancer facts & figures 2021. American Cancer Society; Atlanta, GA: 2021
3	Siegel RL, Miller KD, Fuchs HE and Jemal A: Cancer statistics, 2021. CA Cancer J Clin. 71:7–33. 2021. View Article : Google Scholar : PubMed/NCBI
4	National Cancer Institute, . Cancer Stat Facts: Female Breast Cancer. National Cancer Institute; Bethesda, MD, USA: 2020
5	Atalay G, Biganzoli L, Renard F, Paridaens R, Cufer T, Coleman R, Calvert AH, Gamucci T, Minisini A, Therasse P, et al: Clinical outcome of breast cancer patients with liver metastases alone in the anthracycline-taxane era: A retrospective analysis of two prospective, randomised metastatic breast cancer trials. Eur J Cancer. 39:2439–2449. 2003. View Article : Google Scholar : PubMed/NCBI
6	Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI
7	Eckhardt BL, Francis PA, Parker BS and Anderson RL: Strategies for the discovery and development of therapies for metastatic breast cancer. Nat Rev Drug Discov. 11:479–497. 2012. View Article : Google Scholar : PubMed/NCBI
8	Alcantara SB, Reed W, Willis K, Lee W, Brennan P and Lewis S: Radiologist participation in multi-disciplinary teams in breast cancer improves reflective practice, decision making and isolation. Eur J Cancer Care (Engl). 23:616–623. 2014. View Article : Google Scholar : PubMed/NCBI
9	Hortobagyi GN: Trastuzumab in the treatment of breast cancer. N Engl J Med. 353:1734–1736. 2005. View Article : Google Scholar : PubMed/NCBI
10	Trayes KP and Cokenakes SEH: Breast cancer treatment. Am Fam Physician. 104:171–178. 2021.PubMed/NCBI
11	Loibl S, Poortmans P, Morrow M, Denkert C and Curigliano G: Breast cancer. Lancet. 397:1750–1769. 2021. View Article : Google Scholar : PubMed/NCBI
12	Giordano SH, Buzdar AU and Hortobagyi GN: Breast cancer in men. Ann Intern Med. 137:678–687. 2002. View Article : Google Scholar : PubMed/NCBI
13	Anderson WF, Jatoi I, Tse J and Rosenberg PS: Male breast cancer: A population-based comparison with female breast cancer. J Clin Oncol. 28:232–239. 2010. View Article : Google Scholar : PubMed/NCBI
14	Bartmann C, Wischnewsky M, Stüber T, Stein R, Krockenberger M, Häusler S, Janni W, Kreienberg R, Blettner M, Schwentner L, et al: Pattern of metastatic spread and subcategories of breast cancer. Arch Gynecol Obstet. 295:211–223. 2017. View Article : Google Scholar : PubMed/NCBI
15	Battistoni A, Lantier L, di Tommaso A, Ducournau C, Lajoie L, Samimi M, Coënon L, Rivière C, Epardaud M, Hertereau L, et al: Nasal administration of recombinant Neospora caninum secreting IL-15/IL-15Rα inhibits metastatic melanoma development in lung. J Immunother Cancer. 11:e0066832023. View Article : Google Scholar : PubMed/NCBI
16	Nieto MA: Epithelial plasticity: A common theme in embryonic and cancer cells. Science. 342:12348502013. View Article : Google Scholar : PubMed/NCBI
17	Ma R, Feng Y, Lin S, Chen J, Lin H, Liang X, Zheng H and Cai X: Mechanisms involved in breast cancer liver metastasis. J Transl Med. 13:642015. View Article : Google Scholar : PubMed/NCBI
18	Xie L, Yang Y, Meng J, Wen T, Liu J and Xu H: Cationic polysaccharide spermine-pullulan drives tumor associated macrophage towards M1 phenotype to inhibit tumor progression. Int J Biol Macromol. 123:1012–1019. 2019. View Article : Google Scholar : PubMed/NCBI
19	Liu C, Mohan SC, Wei J, Seki E, Liu M, Basho R, Giuliano AE, Zhao Y and Cui X: Breast cancer liver metastasis: Pathogenesis and clinical implications. Front Oncol. 12:1043772022.
20	Ingber DE: Can cancer be reversed by engineering the tumour microenvironment? Semin Cancer Biol. 18:356–364. 2008. View Article : Google Scholar : PubMed/NCBI
21	Lau EY, Ho NP and Lee TK: Cancer stem cells and their microenvironment: Biology and therapeutic implications. Stem Cells Int. 2017:37141902017. View Article : Google Scholar : PubMed/NCBI
22	Osborne N, Sundseth R, Gay MD, Cao H, Tucker RD, Nadella S, Wang S, Liu X, Kroemer A, Sutton L, et al: Vaccine against gastrin, a polyclonal antibody stimulator, decreases pancreatic cancer metastases. Am J Physiol Gastrointest Liver Physio. 317:G682–G693. 2019. View Article : Google Scholar : PubMed/NCBI
23	Gucalp A, Traina TA, Eisner JR, Parker JS, Selitsky SR, Park BH, Elias AD, Baskin-Bey ES and Cardoso F: Male breast cancer: A disease distinct from female breast cancer. Breast Cancer Res Treat. 173:37–48. 2019. View Article : Google Scholar : PubMed/NCBI
24	Ou J, Peng Y, Deng J, Miao H, Zhou J, Zha L, Zhou R, Yu L, Shi H and Liang H: Endothelial cell-derived fibronectin extra domain A promotes colorectal cancer metastasis via inducing epithelial-mesenchymal transition. Carcinogenesis. 35:1661–1670. 2014. View Article : Google Scholar : PubMed/NCBI