Open Access

Advances in the study of the mechanism of action of miR‑22 in liver lesions (Review)

  • Authors:
    • Minghe Wang
    • Xuejing Wang
    • Yanqi Wang
    • Yikuo Gai
    • Jingran Ye
    • Xinyan Xu
    • Xue You
  • View Affiliations

  • Published online on: September 6, 2024     https://doi.org/10.3892/ol.2024.14674
  • Article Number: 541
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Globally, nearly 2 million deaths annually are attributed to the development of liver diseases, with liver cancer and cirrhosis being particularly prominent, which makes liver disease a significant global health concern. Cirrhosis is closely linked to the evolution of hepatitis, hepatic fibrosis and fatty liver. However, most liver diseases have an insidious onset, are challenging to treat and the prognosis and efficacy of current therapies are unsatisfactory, which can result in irreversible functional damage to the liver. Therefore, there is an urgent need to explore the molecular mechanisms underlying liver disease and identify new biomarkers and therapeutic targets. In previous years, microRNAs (miRs), a class of short non‑coding RNAs comprising 17‑25 nucleotides, have attracted attention for their roles in various types of liver diseases. Among them, miR‑22 serves a unique role in mediating multiple pathway mechanisms and epigenetic modifications and can act both as an inhibitor of liver cancer and a metabolic blocker. Given its close association with the liver, several studies have reported that the differential expression of miR‑22 regulates the metabolic process of liver cancer and is involved in the evolution of hepatic fibrosis and steatohepatitis, making it a potential target for early diagnosis and treatment. The present manuscript aimed to comprehensively review the key role of miR‑22 in the evolution of liver diseases and offer valuable references and guidance for subsequent studies by identifying its specific mechanism of action and future development prospects.
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November-2024
Volume 28 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Wang M, Wang X, Wang Y, Gai Y, Ye J, Xu X and You X: Advances in the study of the mechanism of action of miR‑22 in liver lesions (Review). Oncol Lett 28: 541, 2024.
APA
Wang, M., Wang, X., Wang, Y., Gai, Y., Ye, J., Xu, X., & You, X. (2024). Advances in the study of the mechanism of action of miR‑22 in liver lesions (Review). Oncology Letters, 28, 541. https://doi.org/10.3892/ol.2024.14674
MLA
Wang, M., Wang, X., Wang, Y., Gai, Y., Ye, J., Xu, X., You, X."Advances in the study of the mechanism of action of miR‑22 in liver lesions (Review)". Oncology Letters 28.5 (2024): 541.
Chicago
Wang, M., Wang, X., Wang, Y., Gai, Y., Ye, J., Xu, X., You, X."Advances in the study of the mechanism of action of miR‑22 in liver lesions (Review)". Oncology Letters 28, no. 5 (2024): 541. https://doi.org/10.3892/ol.2024.14674