Open Access

Perioperative serplulimab‑based chemoimmunotherapy in stage IV large cell neuroendocrine carcinoma of the lung: A case report

  • Authors:
    • Shuliang Zhang
    • Jianting Du
    • Chuanquan Lin
    • Maohui Chen
    • Yizhou Huang
    • Chun Chen
    • Bin Zheng
  • View Affiliations

  • Published online on: September 12, 2024     https://doi.org/10.3892/ol.2024.14680
  • Article Number: 547
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Large cell neuroendocrine carcinoma (LCNEC) is a rare and enigmatic tumor, characterized by neuroendocrine features and a poor prognosis similar to small cell lung cancer (SCLC). The present report details the case of a 45‑year‑old male with oligometastatic stage IV LCNEC who achieved clinical cure after undergoing perioperative immunochemotherapy. Despite the typical non‑recommendation of surgery for stage IV cases, based on the insistence of the patient, the present study initiated three cycles of neoadjuvant therapy combining serplulimab (a programmed cell death protein 1 inhibitor) with chemotherapy, resulting in the radiological disappearance of the tumor. Pathological complete response was confirmed following resection of the primary tumor. The treatment continued with three cycles of adjuvant therapy using serplulimab and chemotherapy, followed by maintenance therapy with serplulimab alone. After 17 cycles of maintenance therapy, a positron emission tomography‑computed tomography scan revealed a complete metabolic response of the metastasis, and radiological scans revealed no visible tumor or distant metastasis, indicating a clinical cure. Event‑free survival has exceeded 11 months, and overall survival has exceeded 14 months. The present case highlights the efficacy of immunochemotherapy in treating advanced LCNEC.
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November-2024
Volume 28 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zhang S, Du J, Lin C, Chen M, Huang Y, Chen C and Zheng B: Perioperative serplulimab‑based chemoimmunotherapy in stage IV large cell neuroendocrine carcinoma of the lung: A case report. Oncol Lett 28: 547, 2024.
APA
Zhang, S., Du, J., Lin, C., Chen, M., Huang, Y., Chen, C., & Zheng, B. (2024). Perioperative serplulimab‑based chemoimmunotherapy in stage IV large cell neuroendocrine carcinoma of the lung: A case report. Oncology Letters, 28, 547. https://doi.org/10.3892/ol.2024.14680
MLA
Zhang, S., Du, J., Lin, C., Chen, M., Huang, Y., Chen, C., Zheng, B."Perioperative serplulimab‑based chemoimmunotherapy in stage IV large cell neuroendocrine carcinoma of the lung: A case report". Oncology Letters 28.5 (2024): 547.
Chicago
Zhang, S., Du, J., Lin, C., Chen, M., Huang, Y., Chen, C., Zheng, B."Perioperative serplulimab‑based chemoimmunotherapy in stage IV large cell neuroendocrine carcinoma of the lung: A case report". Oncology Letters 28, no. 5 (2024): 547. https://doi.org/10.3892/ol.2024.14680