Open Access

Fotemustine in recurrent high‑grade glioma: MRI neuro‑radiological findings

  • Authors:
    • Anna Paola Savoldi
    • Elena Anghileri
    • Marco Moscatelli
    • Antonio Silvani
    • Bianca Pollo
    • Cuccarini Valeria
    • Riccardo Pascuzzo
    • Domenico Aquino
    • Marina Grisoli
    • Fabio M. Doniselli
  • View Affiliations

  • Published online on: September 27, 2024     https://doi.org/10.3892/ol.2024.14703
  • Article Number: 570
  • Copyright: © Savoldi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The use of fotemustine (FTM) has been authorized in certain countries for the treatment of recurrent high‑grade gliomas (HGG) after Stupp therapy. However, to the best of our knowledge, no studies have assessed changes in magnetic resonance imaging (MRI) during treatment with FTM monotherapy. The aim of the present study was to assess the neuroradiological findings in a cohort of patients with recurrent HGG treated with FTM monotherapy. Patients with HGG already undergoing the Stupp protocol were retrospectively included. MRIs (pre‑ and post‑FTM treatment) were analyzed by two neuroradiologists in consensus: Volume and diffusion values of the contrast‑enhanced component were measured on T1‑weighted volumetric sequences after gadolinium injection and on apparent diffusion coefficient (ADC) maps, respectively. A total of 19 patients [median age, 49 years; interquartile range (IQR), 43‑57 years] were included, 17 of whom had glioblastoma and 2 had astrocytoma isocitrate dehydrogenase‑mutated grade 4. The median duration of FTM therapy was 4 months (IQR, 2‑6 months). The median tumor volume measured on the contrast‑enhanced component was 2,216 mm3 (IQR, 768‑13,169 mm3) at baseline and 9,217 mm3 (IQR, 3,455‑16,697 mm3) at the end of treatment, with a median change of +38% (IQR, ‑45‑+574%). A total of seven patients showed a volume decrease. ADC value analysis of the enhancement area demonstrated no significant difference between the pre‑ and the post‑FTM treatment periods (P=0.36); however, in three patients, the decreases in ADC levels were particularly marked. In conclusion, the present study described a series of patients with recurrent HGG treated with FTM in monotherapy, demonstrating a prevalent increase in lesion enhancement and three cases of marked restrictions on diffusion‑weighted imaging. Further prospective studies are required to corroborate such preliminary results.
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December-2024
Volume 28 Issue 6

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Spandidos Publications style
Savoldi AP, Anghileri E, Moscatelli M, Silvani A, Pollo B, Valeria C, Pascuzzo R, Aquino D, Grisoli M, Doniselli FM, Doniselli FM, et al: Fotemustine in recurrent high‑grade glioma: MRI neuro‑radiological findings. Oncol Lett 28: 570, 2024.
APA
Savoldi, A.P., Anghileri, E., Moscatelli, M., Silvani, A., Pollo, B., Valeria, C. ... Doniselli, F.M. (2024). Fotemustine in recurrent high‑grade glioma: MRI neuro‑radiological findings. Oncology Letters, 28, 570. https://doi.org/10.3892/ol.2024.14703
MLA
Savoldi, A. P., Anghileri, E., Moscatelli, M., Silvani, A., Pollo, B., Valeria, C., Pascuzzo, R., Aquino, D., Grisoli, M., Doniselli, F. M."Fotemustine in recurrent high‑grade glioma: MRI neuro‑radiological findings". Oncology Letters 28.6 (2024): 570.
Chicago
Savoldi, A. P., Anghileri, E., Moscatelli, M., Silvani, A., Pollo, B., Valeria, C., Pascuzzo, R., Aquino, D., Grisoli, M., Doniselli, F. M."Fotemustine in recurrent high‑grade glioma: MRI neuro‑radiological findings". Oncology Letters 28, no. 6 (2024): 570. https://doi.org/10.3892/ol.2024.14703